Vanillic acid mitigates the impairments in glucose metabolism in HepG2 cells through BAD–GK interaction during hyperinsulinemia

2021 ◽  
Author(s):  
Mohan Sreelekshmi ◽  
Kozhiparambil Gopalan Raghu
Keyword(s):  
Glucose Metabolism ◽  
Vanillic Acid ◽  
Hepg2 Cells

Baicalein improves glucose metabolism in insulin resistant HepG2 cells

2019 ◽  
Vol 854 ◽  
pp. 187-193 ◽  
Author(s):  
Zongchun Yang ◽  
Wei Huang ◽  
Jingsheng Zhang ◽  
Ming Xie ◽  
Xiaowan Wang
Keyword(s):  
Glucose Metabolism ◽  
Hepg2 Cells ◽  
Insulin Resistant

scholarly journals Preparation and Characterization of Auricularia cornea Ehrenb Polysaccharide-Zn Complex and Its Hypoglycemic Activity through Regulating Insulin Resistance in HepG2 Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Tingting Liu ◽  
Shanshan Zhang ◽  
Nan Wang ◽  
Xinle Xu ◽  
Hongcheng Liu ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Glucose Metabolism ◽  
Hepg2 Cells ◽  
Zinc Complex ◽  
Cell Damage ◽  
Hypoglycemic Activity ◽  
Raw Material ◽  
Sugar Chain ◽  
Nuclear Magnetic

With Auricularia cornea Ehrenb polysaccharide (ACEP) as raw material, the purpose of the study was to prepare Auricularia cornea Ehrenb polysaccharide-zinc (ACEP-Zn) complex. Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), nuclear magnetic resonance (NMR), and other means are used to analyze the physical-chemical properties and structure of ACEP and ACEP-Zn, to investigate the inhibition of α-glycosidase and α-amylase enzymes, and to explore its effects on the glucose metabolism of insulin-resistant HepG2 cells. Nuclear magnetic resonance (NMR) results show that a group of COO-, -CH3, and -OH in the sugar chain binds to Zn2+. Compared with the original polysaccharides, the surface morphology of ACEP-Zn changed obviously, and the molecular weight (Mn) of ACEP-Zn decreased, but the molecular agglomeration of ACEP-Zn increased. Moreover, the inhibitory effect of ACEP-Zn on α-glucosidase and α-amylase was stronger than that of the original polysaccharide. The results indicated that the structure of Auricularia cornea Ehrenb polysaccharide was changed obviously after the zinc complex, and its hypoglycemic activity was enhanced in vitro. In the cell experiment, the glucose consumption of IR-HepG2 cells was significantly increased at a concentration of 50–200 μg/mL ( P < 0.05 ). The activity of SOD and NOS significantly increased ( P < 0.01 ), and the activity of intracellular PK increased ( P < 0.05 ). Therefore, it was speculated that the hypoglycemic effect of Auricularia cornea Ehrenb polysaccharide combined with zinc was related to the alleviation of liver cell damage caused by oxidative stress and the improvement of glucose metabolism of IR-HepG2 cells. The study provides a theoretical basis for the application of the polysaccharide-zinc complex in the hypoglycemic functional food field.

scholarly journals Increased glucose metabolism and alpha-glucosidase inhibition in Cordyceps militaris water extract-treated HepG2 cells

2017 ◽  
Vol 11 (3) ◽  
pp. 180 ◽  
Author(s):  
Dae Jung Kim ◽  
Yun Hwan Kang ◽  
Kyoung Kon Kim ◽  
Tae Woo Kim ◽  
Jae Bong Park ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Hepg2 Cells ◽  
Water Extract ◽  
Cordyceps Militaris ◽  
Alpha Glucosidase

scholarly journals Nifuroxazide ameliorates lipid and glucose metabolism in palmitate-induced HepG2 cells

RSC Advances ◽  
2019 ◽  
Vol 9 (67) ◽  
pp. 39394-39404 ◽  
Author(s):  
Jing-Yi Liu ◽  
Yi-Chen Zhang ◽  
Li-Ni Song ◽  
Lin Zhang ◽  
Fang-Yuan Yang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Glucose Metabolism ◽  
Fatty Liver ◽  
Hepg2 Cells ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Inflammation constitutes an important component of non-alcoholic fatty liver disease.

Rb2 inhibits α-glucosidase and regulates glucose metabolism by activating AMPK pathways in HepG2 cells

2017 ◽  
Vol 28 ◽  
pp. 306-313 ◽  
Author(s):  
Hui Teng ◽  
Lei Chen ◽  
Ting Fang ◽  
Benyao Yuan ◽  
Qiyang Lin
Keyword(s):  
Glucose Metabolism ◽  
Hepg2 Cells

scholarly journals Syringaresinol-4- O - β - d -glucoside alters lipid and glucose metabolism in HepG2 cells and C2C12 myotubes

2017 ◽  
Vol 7 (4) ◽  
pp. 453-460 ◽  
Author(s):  
Shuai Wang ◽  
Chongming Wu ◽  
Xin Li ◽  
Yue Zhou ◽  
Quanyang Zhang ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Hepg2 Cells ◽  
C2c12 Myotubes
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