Nicorandil mitigates folic acid‐induced nephrotoxicity in mice: Role of iNOS and eNOS

2021 ◽  
Author(s):  
Dalia M. Ezzat ◽  
Asmaa M. Soliman ◽  
Dalia H. El‐Kashef
Keyword(s):  
Folic Acid

scholarly journals Role of Folic Acid and Energy Intake in Nucleic Acid Synthesis

1959 ◽  
Vol 234 (3) ◽  
pp. 625-627
Author(s):  
Ranjan Mehta ◽  
David A. Vaughan ◽  
Shreepad R. Wagle ◽  
Kendall D. Barbee ◽  
S.P. Mistry ◽  
...  
Keyword(s):  
Folic Acid ◽  
Nucleic Acid ◽  
Energy Intake ◽  
Acid Synthesis ◽  
Nucleic Acid Synthesis

scholarly journals FOLIC ACID, VITAMIN B12, AND DNA METHYLATION: AN UPDATE.

2018 ◽  
Vol 11 (1) ◽  
pp. 17 ◽  
Author(s):  
Bhongir Aparna Varma ◽  
Srilatha Bashetti ◽  
Rajagopalan Vijayaraghavan ◽  
Kumar Sai Sailesh
Keyword(s):  
Dna Methylation ◽  
Folic Acid ◽  
Vitamin B12 ◽  
The Body ◽  
Aberrant Methylation ◽  
Restricted Diet ◽  
Current Review ◽  
Folate And Vitamin B12 ◽  
Methylation Patterns

 Epigenetics is one of the exciting and fastest expanding fields of biology; this is above genetics. Methylation is the process involved in the transfer of methyl group to amino acids, proteins, enzymes and DNA of all the cells, and tissues of the body. During cell-division low folate availability may result in decreased production of thymidine wherein uracil may be substituted in the place of thymidine in the DNA sequence. It was reported that folate and Vitamin B12 restricted diet resulted in aberrant methylation patterns. The current review was undertaken to explore the role of folic acid and Vitamin B12 in DNA methylation.

Antiatherogenic and radioprotective role of folic acid in whole body γ-irradiated mice

2006 ◽  
Vol 292 (1-2) ◽  
pp. 19-25 ◽  
Author(s):  
Madan Sadashiv Pote ◽  
Nitin Motilal Gandhi ◽  
Kaushala Prasad Mishra
Keyword(s):  
Folic Acid ◽  
Whole Body

scholarly journals Congenital heart disease: factor affecting it and role of RBSK in dealing with situation

2018 ◽  
Vol 5 (10) ◽  
pp. 4437
Author(s):  
Martina S. Balat ◽  
Saurabh Kumar Sahu
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Folic Acid ◽  
Middle Class ◽  
Pregnancy Outcome ◽  
Congenital Heart ◽  
Adverse Pregnancy Outcome ◽  
Lower Middle Class ◽  
Adverse Pregnancy

Background: Congenital heart diseases (CHD) is the second leading cause of death in infancy and childhood. So the purpose of this study to know socio-demographic profile and the maternal risk factors affecting CHD, and the role of RBSK in screening with respect to CHD.Methods: A cross-sectional study was conducted during June to October 2016 in Ahmedabad city. Parents of 169 children with CHD who were beneficiaries of RBSK during the previous 3 months were interviewed.Results: The majority of children were in the age group of 0-3 years 49.7% (mean±SD= 4.26±4). Majority of families belonged to the lower middle class IV (41.4%). 44% of mothers had primary education. Mothers with age >30 yrs were 55.6%. Only 30.9% of mothers had taken folic acid during the periconceptional period. Mothers with previous adverse pregnancy outcome were 40.2%. Maternal stress and high blood pressure were present in 33.7% and 24.8% of the mothers respectively. 48% of children were diagnosed through Rashtriya Bal Swasthya Karyakram (RBSK).Conclusions: Lower middle class, lower maternal education, advanced maternal age, low folic acid intake, previous adverse pregnancy outcome, maternal stress and high blood pressure were the leading risk factors for CHD. RBSK is playing important role in screening and diagnosing of patients.

scholarly journals Role of Folate and Folic Acid During Pregnancy

2021 ◽  
Vol 9 (12) ◽  
pp. 1488-1492
Author(s):  
Saniya Sahar
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Maternal Nutrition ◽  
Tissue Growth ◽  
Food Fortification ◽  
Nucleotide Synthesis ◽  
Folic Acid Fortification ◽  
C1 Metabolism ◽  
Pteroylglutamic Acid

Abstract: Pregnancy represents a period of fast tissue growth of maternal and foetal tissues that's related to enhanced energy and nutrient needs. Maternal nutrition throughout gestation period, has being essential for best offspring development, reducing long unwellness burden and for general health throughout life. Maternal Folate throughout pregnancy might have numerous roles in offspring health, as well as neurodevelopment and psychological feature performance in childhood. Folate is crucial for C1 metabolism, a network of pathways concerned in many biological processes as well as nucleotide synthesis, deoxyribonucleic acid repair and methylation reactions. The periconceptional use of pteroylglutamic acid (Folic Acid ) containing supplements reduces the primary incidence, as well as recurrence of neural tube defects. Folic Acid (FA) are artificial form of a necessary vitamin generically considered Folates or B9. It is concerned in one-carbon metabolism, and it's been connected to lowering neural tube Defect (NTD). National programs to mandate fortification of food with Folic Acid have reduced the prevalence of NTDs worldwide . The indisputable protecting role of Folic Acid in the hindrance of NTD, in addition to the low compliance of women to Folic Acid recommendations, has aroused the choice of mandatory Folic Acid fortification, a policy currently in place in over eighty countries worldwide. Mandatory food fortification needs food makers to feature Folic Acid to certain foods (e.g. starch or grain products), whereas voluntary fortification permits Folic Acid to be added to foods at the discretion of manufacturers. Food fortification with Folic Acid because the intervention is likely to achieve increasing Folic Acid intake among populations throughout the world. The objective of this article is to discuss the Role of Folic Acid and Folate during pregnancy and to review the role of Folate and Folic Acid , metabolism , absorption and Folic Acid effects on maternal on the basis of recent findings that are important for implementation of fortified food to design future studies. Keywords: Neurodevelopment, Methylation Reactions, Pteroylglutamic Acid, Bioavailability, Monoglutamates.

scholarly journals Folic acid – role in the body, recommendations and clinical significance

2019 ◽  
Vol 18 (1) ◽  
pp. 50-59 ◽  
Author(s):  
Aneta Myszczyszyn ◽  
Rafał Krajewski ◽  
Monika Ostapów ◽  
Lidia Hirnle
Keyword(s):  
Folic Acid ◽  
Biological Effects ◽  
Folic Acid Supplementation ◽  
The Body ◽  
Leafy Vegetables ◽  
Congenital Defects ◽  
Natural Form ◽  
Vitamin B9 ◽  
Increased Risk

AbstractIntroduction. Folic acid is a compound classified as B group vitamins. In the body it is subject to processes that transfer its inactive form into a form responsible for biological effects of folic acid, i.e. 5-methyltetrahydrofolate (5-MTHF). It is, in particular, responsible for processes of the correct biosynthesis of purine and pyridine bases present in the formation of DNA and RNA molecules. Humans do not synthesize the endogenous form of folic acid; therefore, it is vital to supplement this vitamin in its natural form or multivitamin preparations. The most folic acid is found in the green leafy vegetables (spinach, peas, asparagus) and in offal (liver). An adequate supply of folic acid is especially indicated in pregnant women with a reduced amount of folic acid due to its use by an intensively developing foetus. The recommended dose of folic acid during this period is 0.4 mg/24h and this dose varies depending on the patient’s and her family’s medical history. The updated state of knowledge on the role of vitamin B9 in the body has been presented. The importance of its supplementation in specific clinical cases was analyzed.Summary. Many studies indicate an important role of the folic acid in the prevention of congenital defects of the nervous, cardiovascular and urogenital systems. Its deficiency increases the risk of complications in pregnancy, such as recurrent miscarriages, pre-eclampsia or postpartum haemorrhage. For this reason, a prophylactic folic acid supplementation is recommended, in women with increased risk of its deficiency, in particular.

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