Expression of Concern: Pari, L. and Rajarajeswari, N. (2011). Antioxidant role of coumarin on streptozotocin–nicotinamide‐induced type 2 diabetic rats. J. Biochem. Mol. Toxicol ., 25: 355‐361. https://doi.org/10.1002/jbt.20395

2020 ◽  
Vol 34 (9) ◽  
Keyword(s):  
Diabetic Rats ◽  
Type 2 Diabetic

Role of Metformin in Reversing the Negative Impact of Hyperglycemia on Bone Healing Around Implants Inserted in Type 2 Diabetic Rats

2017 ◽  
Vol 32 (3) ◽  
pp. 547-554 ◽  
Author(s):  
Caroline Serrão ◽  
Marta Bastos ◽  
Daniele Cruz ◽  
Fernando Malta ◽  
Paolla Vallim ◽  
...  
Keyword(s):  
Bone Healing ◽  
Negative Impact ◽  
Diabetic Rats ◽  
Type 2 Diabetic

Acidified nitrite improves wound healing in type 2 diabetic rats: Role of oxidative stress and inflammation

Nitric Oxide ◽  
2020 ◽  
Vol 103 ◽  
pp. 20-28
Author(s):  
Hamideh Afzali ◽  
Mohammad Khaksari ◽  
Reza Norouzirad ◽  
Sajad Jeddi ◽  
Khosrow Kashfi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Diabetic Rats ◽  
Type 2 Diabetic

The modulatory role of prime identified compounds in the bioactive fraction of Homalium zeylanicum in high-fat diet fed-streptozotocin-induced type 2 diabetic rats

2020 ◽  
Vol 260 ◽  
pp. 113099
Author(s):  
Deeptimayee Rout ◽  
Umesh Chandra Dash ◽  
Satish Kanhar ◽  
Sandeep Kumar Swain ◽  
Atish Kumar Sahoo
Keyword(s):  
High Fat Diet ◽  
Diabetic Rats ◽  
High Fat ◽  
Bioactive Fraction ◽  
Type 2 Diabetic

The Therapeutic Role of Very Low-Density Lipoprotein Receptor Gene in Hyperlipidemia in Type 2 Diabetic Rats

2011 ◽  
Vol 22 (3) ◽  
pp. 302-312 ◽  
Author(s):  
Gang Yuan ◽  
Yongjian Liu ◽  
Tingting Sun ◽  
Yongping Xu ◽  
Jianhuan Zhang ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Very Low Density Lipoprotein ◽  
Lipoprotein Receptor ◽  
Density Lipoprotein Receptor ◽  
Type 2 Diabetic

Role of 12-lipoxygenase in decreasing P-cadherin and increasing angiotensin II type 1 receptor expression according to glomerular size in type 2 diabetic rats

2011 ◽  
Vol 300 (4) ◽  
pp. E708-E716 ◽  
Author(s):  
Qiao-Yan Guo ◽  
Li-Ning Miao ◽  
Bing Li ◽  
Fu-Zhe Ma ◽  
Nian Liu ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Diabetic Rats ◽  
Ang Ii ◽  
Direct Infusion ◽  
Protein Expressions ◽  
12 Lipoxygenase ◽  
Type 2 Diabetic

12-lipoxygenase (12-LO) was implicated in the development of diabetic nephropathy (DN), in which the proteinuria was thought to be associated with a decreased expression of glomerular P-cadherin. Therefore, we investigated the role of 12-LO in the glomerular P-cadherin expression in type 2 diabetic rats according to the glomerular sizes. Rats fed with high-fat diet for 6 wk were treated with low-dose streptozotocin. Once diabetes onset, diabetic rats were treated with 12-LO inhibitor cinnamyl-3,4-dihydroxy-cyanocinnamate (CDC) for 8 wk. Then glomeruli were isolated from diabetic and control rats with a sieving method. RT-PCR, Western blotting, and immunofluorescent staining were used for mRNA and protein expressions of P-cadherin and angiotensin II (Ang II) type 1 receptor (AT1). We found that CDC did not affect the glucose levels but completely attenuated diabetic increases in glomerular volume and proteinuria. Diabetes significantly decreased the P-cadherin mRNA and protein expressions and increased the AT1 mRNA and protein expressions in the glomeruli. These changes were significantly prevented by CDC and recaptured by direct infusion of 12-LO product [12(S)-HETE] to normal rats for 7 days. The decreased P-cadherin expression was similar between large and small glomeruli, but the increased AT1 expression was significantly higher in the large than in the small glomeruli from diabetic and 12(S)-HETE-treated rats. Direct infusion of normal rats with Ang II for 14 days also significantly decreased the glomerular P-cadherin expression. These results suggest that diabetic proteinuria is mediated by the activation of 12-LO pathway that is partially attributed to the decreased glomerular P-cadherin expression.

Sign in / Sign up

Export Citation Format

Share Document