Synthesis and characterization of four novel palladium(II) and platinum(II) complexes with 1-(2-aminoethyl)pyrrolidine, diclofenac and mefenamic acid: In vitro effect of these complexes on human serum paraoxanase1 activity

2018 ◽  
Vol 32 (4) ◽  
pp. e22043 ◽  
Author(s):  
Esra Dilek ◽  
Sema Caglar ◽  
Kübra Erdogan ◽  
Bülent Caglar ◽  
Onur Sahin
Keyword(s):  
Human Serum ◽  
Mefenamic Acid ◽  
Synthesis And Characterization ◽  
Vitro Effect

scholarly journals Synthesis and Characterization of Inulin Butyrate Ester, and Evaluation of Its Antioxidant Activity and In Vitro Effect on SCFA Production

2020 ◽  
Vol 72 (11-12) ◽  
pp. 1900323
Author(s):  
Xiaozhen Zhu ◽  
Xia Zhang ◽  
Xuelu Gao ◽  
Xianyao Meng ◽  
Yuetao Yi
Keyword(s):  
Antioxidant Activity ◽  
Synthesis And Characterization ◽  
Vitro Effect

scholarly journals Synthesis and Characterization of Novel Cu(II), Pd(II) and Pt(II) Complexes with 8-Ethyl-2-hydroxytricyclo(7.3.1.02,7)tridecan-13-one-thiosemicarbazone: Antimicrobial and in Vitro Antiproliferative Activity

Molecules ◽  
2016 ◽  
Vol 21 (5) ◽  
pp. 674 ◽  
Author(s):  
Elena Pahonțu ◽  
Codruța Paraschivescu ◽  
Diana-Carolina Ilieș ◽  
Donald Poirier ◽  
Camelia Oprean ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Synthesis And Characterization

Synthesis and Characterization of Injectable Poly(N-isopropylacrylamide)-Based Hydrogels That Support Tissue Formation in Vitro

1999 ◽  
Vol 32 (22) ◽  
pp. 7370-7379 ◽  
Author(s):  
Ranee A. Stile ◽  
Wesley R. Burghardt ◽  
Kevin E. Healy
Keyword(s):  
Synthesis And Characterization ◽  
Tissue Formation

scholarly journals NFB-01. FUNCTIONAL CHARACTERIZATION OF ATRX LOSS IN NF1-ASSOCIATED GLIOMA AND MPNST

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii417-iii418
Author(s):  
Ming Yuan ◽  
Karlyne Reilly ◽  
Christine Pratilas ◽  
Christopher Heaphy ◽  
Fausto Rodriguez
Keyword(s):  
Cell Lines ◽  
Functional Characterization ◽  
Tert Promoter ◽  
Aggressive Tumors ◽  
Sirna Knockdown ◽  
Nih 3T3 ◽  
Vitro Effect ◽  
Murine Glioma

Abstract To identify the biologic relevance of ATRX loss in NF1-associated gliomagenesis, we studied the effects of Atrx loss using four previously characterized Nf1+/-Trp53+/- murine glioma lines. Lines 130G#3 and 158D#8 (corresponding to grade IV and III gliomas, respectively) displayed preserved ATRX protein expression compared to NIH-3T3 cells. We studied the effects of Atrx knockdown in these two lines in the presence and absence of the TERT inhibitor, BIRBR1532. Using a telomere-specific FISH assay, we identified increased signal intensity after Atrx knockdown, only in the presence of the TERT inhibitor. These features are reminiscent of ALT, although there were no significant alterations in cell growth. Next, we studied the effect of ATRX loss in MPNST lines ST88-14, NF90-8, STS-26T. These cell lines all expressed ATRX and DAXX. However, STS-26T contained a TERT promoter mutation and ST88-14 had a known SNP in the TERT promoter, while NF90-8 had no alterations. ATRX siRNA knockdown showed no significant effects in cell proliferation or apoptosis. However, ATRX knockdown resulted in rare ultra-bright foci, indicative of ALT. Next, we studied the in vitro effect of the ATR inhibitor VE-821 in MPNST cell lines. Only NF90-8 (lacking TERT alterations) demonstrated a decrease in growth after ATRX knockdown and VE-821 treatment. However, ATRX knockdown alone did not affect sensitivity to carboplatin. Our findings further support a role for ATRX loss with subsequent ALT activation in a biologic subset of NF1-associated malignancies, thereby opening an opportunity for therapeutic targeting of these aggressive tumors using specific classes of drugs.

In vitro stereoselective degradation of carprofen glucuronide by human serum albumin. Characterization of sites and reactive amino acids

Chirality ◽  
2000 ◽  
Vol 12 (2) ◽  
pp. 53-62 ◽  
Author(s):  
H�l�ne Georges ◽  
Nathalie Presle ◽  
Thierry Buronfosse ◽  
Sylvie Fournel-Gigleux ◽  
Patrick Netter ◽  
...  
Keyword(s):  
Amino Acids ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Stereoselective Degradation
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