Silk fibroin has a protective effect against high glucose induced apoptosis in HIT-T15 cells

2010 ◽  
Vol 25 (4) ◽  
pp. 238-243 ◽  
Author(s):  
Jun Hong Park ◽  
YoonYi Nam ◽  
So-Young Park ◽  
Jin-Kyung Kim ◽  
Nong-Hoon Choe ◽  
...  
Keyword(s):  
Protective Effect ◽  
Silk Fibroin ◽  
High Glucose ◽  
Induced Apoptosis

scholarly journals Protective effect of hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro

2015 ◽  
Vol 12 (3) ◽  
pp. 3986-3992 ◽  
Author(s):  
YANG YU ◽  
XIAOYE MA ◽  
TAO YANG ◽  
BO LI ◽  
KELIANG XIE ◽  
...  
Keyword(s):  
Protective Effect ◽  
Schwann Cells ◽  
High Glucose ◽  
Rich Medium ◽  
Induced Apoptosis

Protective effect of fermented Diospyros lotus L. extracts against the high glucose‐induced apoptosis of MIN6 cells

2021 ◽  
Vol 45 (4) ◽  
Author(s):  
Hao Yin ◽  
Huan‐huan Yan ◽  
Chen‐qiang Qin ◽  
Hai‐rong Li ◽  
Xue Li ◽  
...  
Keyword(s):  
Protective Effect ◽  
High Glucose ◽  
Min6 Cells ◽  
Diospyros Lotus ◽  
Induced Apoptosis

The Protective Effect of Tetrahydroxystilbene Glucoside on High Glucose-Induced Injury in Human Umbilical Vein Endothelial Cells through the PI3K/Akt/eNOS Pathway and Regulation of Bcl-2/Bax

2021 ◽  
pp. 1-10
Author(s):  
Jiankun Cui ◽  
Bo Zhang ◽  
Min Gao ◽  
Baohai Liu ◽  
Cong Dai ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Protective Effect ◽  
High Glucose ◽  
Umbilical Vein ◽  
Vascular Complications ◽  
Dependent Manner ◽  
Human Umbilical Vein ◽  
Induced Apoptosis ◽  
Umbilical Vein Endothelial Cells

Endothelial dysfunction plays a central role in the patho­genesis of diabetic vascular complications. 2,3,5,4′-tetra­hydroxystilbene-2-O-β-D-glucoside (TSG), an active component extracted from the roots of Polygonum multiflorum Thunb, has been shown to have strong antioxidant and antiapoptotic activities. In the present study, we investigated the protective effect of TSG on apoptosis induced by high glucose in human umbilical vein endothelial cells (HUVECs) and the possible mechanisms. Our data demonstrated that TSG significantly reversed the high glucose-induced decrease in cell viability, suppressed high glucose-induced generation of intracellular reactive oxygen species (ROS), the activity of caspase-3, and decreased the percentage of apoptotic cells in a dose-dependent manner. In addition, we found that TSG not only increased the expression of Bcl-2, while decreasing Bax expression, but also activated phosphorylation of Akt and endothelial nitric oxide synthase (eNOS) with subsequent nitric oxide production and ultimately reduced high glucose-induced apoptosis. However, the antiapoptotic effects of TSG were abrogated by pretreatment of the cells with PI3K inhibitor (LY294002) or eNOS inhibitor N<sup>G</sup>-L-nitro-arginine methyl ester, respectively. These results suggest that TSG inhibits high glucose-induced apoptosis in HUVECs through inhibition of ROS production, activation of the PI3K/Akt/eNOS pathway, and upregulation of the Bcl-2/Bax ratio, and thus may demonstrate significant potential for preventing diabetic cardiovascular complications.

The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells

2019 ◽  
Vol 69 ◽  
pp. 66-71 ◽  
Author(s):  
Qianlei Yang ◽  
Zhen Zhu ◽  
Luna Wang ◽  
Haixuan Xia ◽  
Jiayuan Mao ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Protective Effect ◽  
Silk Fibroin ◽  
High Glucose ◽  
Hepg2 Cells

MicroRNA-34a regulates high glucose-induced apoptosis in H9c2 cardiomyocytes

2013 ◽  
Vol 33 (6) ◽  
pp. 834-839 ◽  
Author(s):  
Fang Zhao ◽  
Bo Li ◽  
Yin-zhi Wei ◽  
Bin Zhou ◽  
Han Wang ◽  
...  
Keyword(s):  
High Glucose ◽  
H9c2 Cardiomyocytes ◽  
Induced Apoptosis
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