scholarly journals Microfluidic enhancement of intramedullary pressure increases interstitial fluid flow and inhibits bone loss in hindlimb suspended mice

2010 ◽  
Vol 25 (8) ◽  
pp. 1798-1807 ◽  
Author(s):  
Ronald Y Kwon ◽  
Diana R Meays ◽  
W Joyce Tang ◽  
John A Frangos
Keyword(s):  
Fluid Flow ◽  
Bone Loss ◽  
Interstitial Fluid ◽  
Interstitial Fluid Flow ◽  
Intramedullary Pressure

scholarly journals Skeletal Adaptation to Intramedullary Pressure-Induced Interstitial Fluid Flow Is Enhanced in Mice Subjected to Targeted Osteocyte Ablation

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e33336 ◽  
Author(s):  
Ronald Y. Kwon ◽  
Diana R. Meays ◽  
Alexander S. Meilan ◽  
Jeremiah Jones ◽  
Rosa Miramontes ◽  
...  
Keyword(s):  
Fluid Flow ◽  
Interstitial Fluid ◽  
Interstitial Fluid Flow ◽  
Intramedullary Pressure ◽  
Skeletal Adaptation

scholarly journals On the characterization of interstitial fluid flow in the skeletal muscle endomysium

2020 ◽  
Vol 102 ◽  
pp. 103504 ◽  
Author(s):  
Qiuyun Wang ◽  
Shaopeng Pei ◽  
X. Lucas Lu ◽  
Liyun Wang ◽  
Qianhong Wu
Keyword(s):  
Skeletal Muscle ◽  
Fluid Flow ◽  
Interstitial Fluid ◽  
Interstitial Fluid Flow

scholarly journals Interstitial flow promotes macrophage polarization toward an M2 phenotype

2018 ◽  
Vol 29 (16) ◽  
pp. 1927-1940 ◽  
Author(s):  
Ran Li ◽  
Jean Carlos Serrano ◽  
Hao Xing ◽  
Tara A. Lee ◽  
Hesham Azizgolshani ◽  
...  
Keyword(s):  
Fluid Flow ◽  
Tumor Microenvironment ◽  
Tumor Progression ◽  
Cancer Cell ◽  
Interstitial Fluid ◽  
Macrophage Polarization ◽  
Interstitial Flow ◽  
Interstitial Fluid Flow ◽  
M2 Polarization ◽  
Tumor Tissues

Tumor tissues are characterized by an elevated interstitial fluid flow from the tumor to the surrounding stroma. Macrophages in the tumor microenvironment are key contributors to tumor progression. While it is well established that chemical stimuli within the tumor tissues can alter macrophage behaviors, the effects of mechanical stimuli, especially the flow of interstitial fluid in the tumor microenvironment, on macrophage phenotypes have not been explored. Here, we used three-dimensional biomimetic models to reveal that macrophages can sense and respond to pathophysiological levels of interstitial fluid flow reported in tumors (∼3 µm/s). Specifically, interstitial flow (IF) polarizes macrophages toward an M2-like phenotype via integrin/Src-mediated mechanotransduction pathways involving STAT3/6. Consistent with this flow-induced M2 polarization, macrophages treated with IF migrate faster and have an enhanced ability to promote cancer cell migration. Moreover, IF directs macrophages to migrate against the flow. Since IF emanates from the tumor to the surrounding stromal tissues, our results suggest that IF could not only induce M2 polarization of macrophages but also recruit these M2 macrophages toward the tumor masses, contributing to cancer cell invasion and tumor progression. Collectively, our study reveals that IF could be a critical regulator of tumor immune environment.

Interstitial fluid flow within bone canaliculi and electro-chemo-mechanical features of the canalicular milieu

2012 ◽  
Vol 12 (3) ◽  
pp. 533-553 ◽  
Author(s):  
Vittorio Sansalone ◽  
Joanna Kaiser ◽  
Salah Naili ◽  
Thibault Lemaire
Keyword(s):  
Fluid Flow ◽  
Interstitial Fluid ◽  
Interstitial Fluid Flow

scholarly journals The Effect of Aquaporin-4 Knockout on Interstitial Fluid Flow and the Structure of the Extracellular Space in the Deep Brain

2018 ◽  
Vol 9 (5) ◽  
pp. 808 ◽  
Author(s):  
Ze Teng ◽  
Aibo Wang ◽  
Peng Wang ◽  
Rui Wang ◽  
Wei Wang ◽  
...  
Keyword(s):  
Fluid Flow ◽  
Extracellular Space ◽  
Interstitial Fluid ◽  
Aquaporin 4 ◽  
Interstitial Fluid Flow ◽  
Deep Brain
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