The glucocorticoid receptor in Osterix‐expressing cells regulates bone mass, bone marrow adipose tissue, and systemic metabolism in female mice during aging

2021 ◽  
Author(s):  
Jessica L. Pierce ◽  
Anuj K. Sharma ◽  
Rachel L. Roberts ◽  
Kanglun Yu ◽  
Debra L. Irsik ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Bone Mass ◽  
Glucocorticoid Receptor ◽  
Female Mice ◽  
Bone Marrow Adipose Tissue ◽  
Marrow Adipose Tissue

scholarly journals A High Fat Diet Increases Bone Marrow Adipose Tissue (MAT) But Does Not Alter Trabecular or Cortical Bone Mass in C57BL/6J Mice

2015 ◽  
Vol 230 (9) ◽  
pp. 2032-2037 ◽  
Author(s):  
Casey R. Doucette ◽  
Mark C. Horowitz ◽  
Ryan Berry ◽  
Ormond A. MacDougald ◽  
Rea Anunciado-Koza ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Bone Mass ◽  
Cortical Bone ◽  
High Fat Diet ◽  
High Fat ◽  
Bone Marrow Adipose Tissue ◽  
Marrow Adipose Tissue ◽  
Cortical Bone Mass

scholarly journals Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society

2021 ◽  
Vol 12 ◽  
Author(s):  
Stephanie Lucas ◽  
Michaela Tencerova ◽  
Benoit von der Weid ◽  
Thomas Levin Andersen ◽  
Camille Attané ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Working Group ◽  
Cell Types ◽  
Bone Marrow Adipose Tissue ◽  
Marrow Adipose Tissue ◽  
Marrow Adiposity ◽  
Group Members ◽  
Number Of Publications ◽  
Different Sources

Over the last two decades, increased interest of scientists to study bone marrow adiposity (BMA) in relation to bone and adipose tissue physiology has expanded the number of publications using different sources of bone marrow adipose tissue (BMAT). However, each source of BMAT has its limitations in the number of downstream analyses for which it can be used. Based on this increased scientific demand, the International Bone Marrow Adiposity Society (BMAS) established a Biobanking Working Group to identify the challenges of biobanking for human BMA-related samples and to develop guidelines to advance establishment of biobanks for BMA research. BMA is a young, growing field with increased interest among many diverse scientific communities. These bring new perspectives and important biological questions on how to improve and build an international community with biobank databases that can be used and shared all over the world. However, to create internationally accessible biobanks, several practical and legislative issues must be addressed to create a general ethical protocol used in all institutes, to allow for exchange of biological material internationally. In this position paper, the BMAS Biobanking Working Group describes similarities and differences of patient information (PIF) and consent forms from different institutes and addresses a possibility to create uniform documents for BMA biobanking purposes. Further, based on discussion among Working Group members, we report an overview of the current isolation protocols for human bone marrow adipocytes (BMAds) and bone marrow stromal cells (BMSCs, formerly mesenchymal), highlighting the specific points crucial for effective isolation. Although we remain far from a unified BMAd isolation protocol and PIF, we have summarized all of these important aspects, which are needed to build a BMA biobank. In conclusion, we believe that harmonizing isolation protocols and PIF globally will help to build international collaborations and improve the quality and interpretation of BMA research outcomes.

Bone marrow adipose tissue content in Latino adolescents with prediabetes and obesity

Obesity ◽  
2021 ◽  
Author(s):  
Kiley B. Vander Wyst ◽  
Houchun H. Hu ◽  
Armando Peña ◽  
Micah L. Olson ◽  
Smita S. Bailey ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Latino Adolescents ◽  
Bone Marrow Adipose Tissue ◽  
Marrow Adipose Tissue ◽  
Tissue Content

scholarly journals Bone marrow adipose tissue does not express UCP1 during development or adrenergic-induced remodeling

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Clarissa S. Craft ◽  
Hero Robles ◽  
Madelyn R. Lorenz ◽  
Eric D. Hilker ◽  
Kristann L. Magee ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Uncoupling Protein ◽  
Enrichment Analysis ◽  
Whole Body ◽  
Mineral Density ◽  
Bone Marrow Adipose Tissue ◽  
Marrow Adipose Tissue ◽  
Reporter Mice ◽  
Brown Adipose

AbstractAdipocytes within the skeleton are collectively termed bone marrow adipose tissue (BMAT). BMAT contributes to peripheral and local metabolism, however, its capacity for cell-autonomous expression of uncoupling protein 1 (UCP1), a biomarker of beige and brown adipogenesis, remains unclear. To overcome this, Ucp1-Cre was used to drive diphtheria toxin expression in cells expressing UCP1 (Ucp1Cre+/DTA+). Despite loss of brown adipose tissue, BMAT volume was not reduced in Ucp1Cre+/DTA+ mice. Comparably, in mTmG reporter mice (Ucp1Cre+/mTmG+), Ucp1-Cre expression was absent from BMAT in young (3-weeks) and mature (16-weeks) male and female mice. Further, β3-agonist stimulation failed to induce Ucp1-Cre expression in BMAT. This demonstrates that BMAT adipocytes are not UCP1-expressing beige/brown adipocytes. Thus, to identify novel and emerging roles for BMAT adipocytes in skeletal and whole-body homeostasis, we performed gene enrichment analysis of microarray data from adipose tissues of adult rabbits. Pathway analysis revealed genetic evidence for differences in BMAT including insulin resistance, decreased fatty acid metabolism, and enhanced contributions to local processes including bone mineral density through candidate genes such as osteopontin. In sum, this supports a paradigm by which BMAT adipocytes are a unique subpopulation that is specialized to support cells within the skeletal and hematopoietic niche.

Sign in / Sign up

Export Citation Format

Share Document