scholarly journals Molecular and cellular mechanisms of delayed fracture healing in Mmp10 (Stromelysin 2) knockout mice

2021 ◽  
Author(s):  
José Valdés‐Fernández ◽  
Tania López‐Martínez ◽  
Purificación Ripalda‐Cemboráin ◽  
Isabel A. Calvo ◽  
Borja Sáez ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Knockout Mice ◽  
Cellular Mechanisms ◽  
Delayed Fracture ◽  
Delayed Fracture Healing

scholarly journals Delayed fracture healing in Mmp10 (Stromelysin 2) knockout mice: Molecular and cellular mechanism

Bone Reports ◽  
2020 ◽  
Vol 13 ◽  
pp. 100626
Author(s):  
José Valdés-Fernández ◽  
Tania López-Martínez ◽  
Purificación Ripalda-Cemboráin ◽  
Isabel Calvo ◽  
Borja Sáez ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Knockout Mice ◽  
Cellular Mechanism ◽  
Delayed Fracture ◽  
Delayed Fracture Healing

Delayed fracture healing in iNOS knockout mice

2004 ◽  
Vol 199 (3) ◽  
pp. 49
Author(s):  
Fayez F. Safadi ◽  
Philip P. Stapleton ◽  
Tracy A. Freeman ◽  
Julian L. Casteneda ◽  
Israel Arango ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Knockout Mice ◽  
Delayed Fracture ◽  
Delayed Fracture Healing ◽  
Inos Knockout Mice

scholarly journals Anabolic Therapies in Osteoporosis and Bone Regeneration

2018 ◽  
Vol 20 (1) ◽  
pp. 83 ◽  
Author(s):  
Gabriele Russow ◽  
Denise Jahn ◽  
Jessika Appelt ◽  
Sven Märdian ◽  
Serafeim Tsitsilonis ◽  
...  
Keyword(s):  
Bone Formation ◽  
Fracture Healing ◽  
Bone Regeneration ◽  
Treatment Options ◽  
Therapeutic Approaches ◽  
Delayed Fracture ◽  
Stimulate Bone Formation ◽  
Intrinsic Factors ◽  
Delayed Fracture Healing ◽  
Extrinsic And Intrinsic Factors

Osteoporosis represents the most common bone disease worldwide and results in a significantly increased fracture risk. Extrinsic and intrinsic factors implicated in the development of osteoporosis are also associated with delayed fracture healing and impaired bone regeneration. Based on a steadily increasing life expectancy in modern societies, the global implications of osteoporosis and impaired bone healing are substantial. Research in the last decades has revealed several molecular pathways that stimulate bone formation and could be targeted to treat both osteoporosis and impaired fracture healing. The identification and development of therapeutic approaches modulating bone formation, rather than bone resorption, fulfils an essential clinical need, as treatment options for reversing bone loss and promoting bone regeneration are limited. This review focuses on currently available and future approaches that may have the potential to achieve these aims.

Single Nucleotide Polymorphisms in Osteogenic Genes in Atrophic Delayed Fracture-Healing

2014 ◽  
Vol 96 (15) ◽  
pp. 1242-1248 ◽  
Author(s):  
Vikram Sathyendra ◽  
Henry J. Donahue ◽  
Kent E. Vrana ◽  
Arthur Berg ◽  
David Fryzel ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Fracture Healing ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Delayed Fracture ◽  
Delayed Fracture Healing

Delayed fracture healing in tetranectin-deficient mice

2013 ◽  
Vol 31 (4) ◽  
pp. 399-408 ◽  
Author(s):  
Kousuke Iba ◽  
Yasuhisa Abe ◽  
Takako Chikenji ◽  
Kumiko Kanaya ◽  
Hironori Chiba ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Delayed Fracture ◽  
Delayed Fracture Healing ◽  
Deficient Mice

scholarly journals Severe Hemorrhagic Shock Leads to a Delayed Fracture Healing and Decreased Bone Callus Strength in a Mouse Model

2017 ◽  
Vol 475 (11) ◽  
pp. 2783-2794 ◽  
Author(s):  
Katrin Bundkirchen ◽  
Christian Macke ◽  
Janin Reifenrath ◽  
Luisa Marilena Schäck ◽  
Sandra Noack ◽  
...  
Keyword(s):  
Mouse Model ◽  
Hemorrhagic Shock ◽  
Fracture Healing ◽  
Delayed Fracture ◽  
Delayed Fracture Healing ◽  
Bone Callus

scholarly journals Impairment of maturation of BMP-6 (35kDa) correlates with delayed fracture healing in experimental diabetes

2020 ◽  
Author(s):  
Qi-Dong Guo ◽  
Wei-Jie Wang ◽  
Rami Abboud ◽  
Zheng Guo
Keyword(s):  
Fracture Healing ◽  
Experimental Diabetes ◽  
Primary Study ◽  
Loading Capacity ◽  
Western Blot Assay ◽  
Delayed Fracture ◽  
X Ray ◽  
Delayed Fracture Healing ◽  
The Difference ◽  
Molecular Therapeutic

Abstract Background: Although it is known that diabetes interferes with fracture healing, the mechanisms remain poorly understood. The aim of this study was to investigate the correlation of BMP-6 and BMP-9 with the impairment in fracture healing in diabetes, by analyses of the difference in size and calcification of the callus, mechanical endurance and expressing BMP-6 and BMP-9 in the callus, using a clinical related diabetic rodent model. Methods: We evaluated femur fracture healing by quantification of size and calcification of the callus by X-ray, histological and histochemical images, loading capacity of the fractured bone and amount of BMP-6 in the callus and the bones using Western blot assay. Results: Significant upregulation of BMP-6 in the callus and the fractured bones of both non-diabetic and the diabetic animals was observed, at the end of the 2nd and the 4th weeks after fracture. However, significantly lower levels of BMP-6 at 35kDa with smaller sizes of calcified callus and poor loading capacity of the healing bones were detected in the diabetic animals, compared to the non-diabetic controls. The impairment of the maturation procedure of BMP-6 (35 kDa) from precursors may be underlying the downregulation of the BMP-6 in diabetic animals. Conclusions: It could be concluded that the delayed fracture healing in the diabetic animals is correlated with deficiency of BMP-6 (35 kDa), which may be caused by impairment of maturation procedure of BMP-6 from precursors to functioning format. This is a primary study but an important step to explore the molecular pathogenesis of impairment of fracture healing in diabetes and to molecular therapeutic approach for the impairment of fracture healing.

scholarly journals Inhibition of β-catenin signaling in chondrocytes induces delayed fracture healing in mice

2011 ◽  
Vol 30 (2) ◽  
pp. 304-310 ◽  
Author(s):  
Yang Huang ◽  
Xiaoling Zhang ◽  
Kewei Du ◽  
Fei Yang ◽  
Yu Shi ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Delayed Fracture ◽  
Delayed Fracture Healing

scholarly journals Disturbed remodeling and delayed fracture healing in pediatric pycnodysostosis patients

2019 ◽  
Vol 16 (5) ◽  
pp. 373-377
Author(s):  
Simran Grewal ◽  
Özgür Kilic ◽  
C. Dilara Savci-Heijink ◽  
Peter Kloen
Keyword(s):  
Fracture Healing ◽  
Delayed Fracture ◽  
Delayed Fracture Healing
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