Efficacy of Zoledronic Acid in Maintaining Areal and Volumetric Bone Density After Combined Denosumab and Teriparatide Administration: DATA‐HD Study Extension

2021 ◽  
Author(s):  
Sabashini K Ramchand ◽  
Natalie L David ◽  
Hang Lee ◽  
Richard Eastell ◽  
Joy N Tsai ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Bone Density ◽  
Volumetric Bone Density

scholarly journals Skeletal Microstructure and Estimated Bone Strength Improve Following Parathyroidectomy in Primary Hyperparathyroidism

2017 ◽  
Vol 103 (1) ◽  
pp. 196-205 ◽  
Author(s):  
Natalie E Cusano ◽  
Mishaela R Rubin ◽  
Barbara C Silva ◽  
Yu-Kwang Donovan Tay ◽  
John M Williams ◽  
...  
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Bone Density ◽  
Primary Hyperparathyroidism ◽  
Fracture Risk ◽  
Bone Strength ◽  
Failure Load ◽  
Mineral Density ◽  
Element Analysis ◽  
Volumetric Bone Density

Abstract Context High-resolution peripheral quantitative computed tomography (HRpQCT) is a noninvasive imaging technology that can provide insight into skeletal microstructure and strength. In asymptomatic primary hyperparathyroidism (PHPT), HRpQCT imaging has demonstrated both decreased cortical and trabecular indices, consistent with evidence for increased fracture risk. There are limited data regarding changes in HRpQCT parameters postparathyroidectomy. Objective To evaluate changes in skeletal microstructure by HRpQCT in subjects with PHPT after parathyroidectomy. Design We studied 29 subjects with PHPT (21 women, 8 men) with HRpQCT at baseline and 6, 12, 18, and 24 months postparathyroidectomy. Main Outcome Measures Volumetric bone mineral density, microarchitectural indices, and finite element analysis at the distal radius and tibia. Results At both the radius and tibia, there were significant improvements in total, cortical, and trabecular volumetric bone density as early as 6 months postparathyroidectomy (24-month values for total volumetric bone density, radius: +2.8 ± 4%, tibia: +4.4 ± 4%; P < 0.0001 for both), cortical thickness (radius: +1.1 ± 2%, tibia: +2.0 ± 3%; P < 0.01 for both), and trabecular bone volume (radius: +3.8 ± 5%, tibia: +3.2 ± 4%; P < 0.0001 for both). At both sites, by finite element analysis, stiffness and failure load were improved starting at 6 months postparathyroidectomy (24-month values for failure load, radius: +6.2 ± 6%, tibia: +4.8 ± 7%; P < 0.0001 for both). Conclusions These results provide information about skeletal microarchitecture in subjects with PHPT followed through 2 years after parathyroidectomy. Estimated bone strength is improved, consistent with data showing decreased fracture risk postparathyroidectomy.

scholarly journals The Prevalence of Vertebral Fractures Is Associated With Reduced Hip Bone Density and Inferior Peripheral Appendicular Volumetric Bone Density and Structure in Older Women

2017 ◽  
Vol 33 (2) ◽  
pp. 250-260 ◽  
Author(s):  
Lisa Johansson ◽  
Daniel Sundh ◽  
Michael Zoulakis ◽  
Robert Rudäng ◽  
Anna Darelid ◽  
...  
Keyword(s):  
Bone Density ◽  
Older Women ◽  
Vertebral Fractures ◽  
Volumetric Bone Density

Low volumetric bone density is a risk factor for early complications after spine fusion surgery

2020 ◽  
Vol 31 (4) ◽  
pp. 647-654 ◽  
Author(s):  
Y. Liu ◽  
A. Dash ◽  
A. Krez ◽  
H. J. Kim ◽  
M. Cunningham ◽  
...  
Keyword(s):  
Risk Factor ◽  
Bone Density ◽  
Spine Fusion ◽  
Early Complications ◽  
Fusion Surgery ◽  
Volumetric Bone Density

Estrogen-specific action on bone geometry and volumetric bone density: Longitudinal observations in an adult with complete androgen insensitivity

Bone ◽  
2009 ◽  
Vol 45 (2) ◽  
pp. 392-397 ◽  
Author(s):  
Youri Taes ◽  
Bruno Lapauw ◽  
Sara Vandewalle ◽  
Hans Zmierczak ◽  
Stefan Goemaere ◽  
...  
Keyword(s):  
Bone Density ◽  
Bone Geometry ◽  
Androgen Insensitivity ◽  
Volumetric Bone Density

Estrogen-specific action on bone geometry and volumetric bone density: Longitudinal observations in an adult with complete androgen insensitivity

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S233
Author(s):  
Y.E. Taes ◽  
B. Lapauw ◽  
S. Vandewalle ◽  
H. Zmierczak ◽  
S. Goemaere ◽  
...  
Keyword(s):  
Bone Density ◽  
Bone Geometry ◽  
Androgen Insensitivity ◽  
Volumetric Bone Density
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