scholarly journals Exogenous PTH‐Related Protein and PTH Improve Mineral and Skeletal Status in 25‐Hydroxyvitamin D‐1α‐Hydroxylase and PTH Double Knockout Mice

2020 ◽  
Vol 35 (8) ◽  
pp. 1614-1616
Author(s):  
Yingben Xue ◽  
Zengli Zhang ◽  
Andrew C Karaplis ◽  
Geoffrey N Hendy ◽  
David Goltzman, and ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Related Protein ◽  
Double Knockout ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Skeletal Status

scholarly journals Exogenous PTH-Related Protein and PTH Improve Mineral and Skeletal Status in 25-Hydroxyvitamin D-1α-Hydroxylase and PTH Double Knockout Mice

2005 ◽  
Vol 20 (10) ◽  
pp. 1766-1777 ◽  
Author(s):  
Yingben Xue ◽  
Zengli Zhang ◽  
Andrew C Karaplis ◽  
Geoffrey N Hendy ◽  
David Goltzman ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Related Protein ◽  
Double Knockout ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Skeletal Status

scholarly journals Hypercalcemia due to sun exposure in a patient with multiple myeloma and elevated parathyroid hormone-related protein

2003 ◽  
pp. 351-355 ◽  
Author(s):  
PD Papapetrou ◽  
M Bergi-Stamatelou ◽  
H Karga ◽  
S Thanou
Keyword(s):  
Multiple Myeloma ◽  
Parathyroid Hormone ◽  
Sun Exposure ◽  
High Serum ◽  
Related Protein ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Parathyroid Hormone Related Protein ◽  
25 Hydroxyvitamin D

A patient with multiple myeloma who developed hypercalcemia during three different stages of his disease, with a different hypercalcemic agent elevated in his serum on each occasion, is described. The initial episode of hypercalcemia was associated with high serum interleukin-6 (IL-6). After treatment for myeloma normocalcemia was achieved. Subsequently, a relapse of hypercalcemia occurred, this time characterized by frankly elevated plasma parathyroid hormone-related protein (PTHrP) but normal IL-6. Monotherapy with pamidronate infusions resulted in remission of the hypercalcemia and a significant fall in PTHrP levels. A third spell of hypercalcemia characterized by an acute rise in serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D to abnormally high levels occurred during the summer season after prolonged and intense exposure to the sun.

scholarly journals Conflicting actions of parathyroid hormone-related protein and serum calcium as regulators of 25-hydroxyvitamin D(3)-1 alpha-hydroxylase expression in a nude rat model of humoral hypercalcemia of malignancy

2001 ◽  
Vol 171 (2) ◽  
pp. 249-257 ◽  
Author(s):  
T Michigami ◽  
H Yamato ◽  
H Suzuki ◽  
Y Nagai-Itagaki ◽  
K Sato ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Related Protein ◽  
Humoral Hypercalcemia Of Malignancy ◽  
Vitamin D Metabolism ◽  
Hydroxyvitamin D ◽  
Humoral Hypercalcemia ◽  
Parathyroid Hormone Related Protein ◽  
Severe Hypercalcemia ◽  
25 Hydroxyvitamin D

In patients with humoral hypercalcemia of malignancy (HHM), serum levels of 1,25-dihydroxyvitamin D (1,25(OH)(2)D) are generally low, although the pathophysiology of the impaired vitamin D metabolism is not fully understood. In the present study, we have investigated vitamin D metabolism in our newly developed rat model of HHM in which a human infantile fibrosarcoma producing parathyroid hormone-related protein (PTHrP), named OMC-1, was inoculated s.c. into athymic nude rats. In OMC-1-bearing rats, the serum concentration of 1,25(OH)(2)D was markedly reduced when the animals exhibited severe hypercalcemia (Ca > or =15 mg/dl), while it was rather elevated in those with mild hypercalcemia. To further examine whether serum Ca levels affect 1,25(OH)(2)D concentration, we administered bisphosphonate YM529 to OMC-1-bearing rats when they exhibited severe hypercalcemia. The restoration of the serum Ca level by administration of YM529 was accompanied by a marked increase in the 1,25(OH)(2)D level, suggesting that the serum Ca level itself plays an important role in the regulation of the 1,25(OH)(2)D level in these rats. On the other hand, when the OMC-1-bearing rats were treated with a neutralizing antibody against PTHrP, serum 1,25(OH)(2)D levels remained low despite the reduction in serum Ca levels. Expression of 25-hydroxyvitamin D-1 alpha-hydroxylase (1 alpha-hydroxylase) in kidney was decreased in OMC-1-bearing rats with severe hypercalcemia, and markedly enhanced after treatment with bisphosphonate. This enhancement in 1 alpha-hydroxylase expression was not observed after treatment with the antibody against PTHrP. These results suggest that PTHrP was responsible for the enhanced expression of 1 alpha-hydroxylase in YM529-treated rats, and that hypercalcemia played a role in reducing the serum 1,25(OH)(2)D level in OMC-1-bearing rats by suppressing the PTHrP-induced expression of the 1 alpha-hydroxylase gene.

Abstract # OR-8: Serum 25-Hydroxyvitamin D Associates with Human Leukocyte Antigen (HLA) Polymorphisms

2016 ◽  
Vol 22 ◽  
pp. 6
Author(s):  
Leena Kinnunen ◽  
Valma Harjutsalo ◽  
Heljä-Marja Surcel ◽  
Christel Lamberg-Allardt ◽  
Jaakko Tuomilehto ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

High Prevalence of Low Serum 25-Hydroxyvitamin D Levels and Hyperparathyroidism in Fontan

2015 ◽  
Vol 63 (S 03) ◽  
Author(s):  
F.E.A. Udink ten Cate ◽  
F. Holler ◽  
T. Hannes ◽  
I. Germund ◽  
M. Emmel ◽  
...  
Keyword(s):  
Hydroxyvitamin D ◽  
High Prevalence ◽  
25 Hydroxyvitamin D ◽  
Low Serum
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