scholarly journals Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development

2018 ◽  
Vol 33 (10) ◽  
pp. 1748-1759 ◽  
Author(s):  
Cristal S Yee ◽  
Jennifer O Manilay ◽  
Jiun C Chang ◽  
Nicholas R Hum ◽  
Deepa K Murugesh ◽  
...  
Keyword(s):  
Bone Mass ◽  
B Cell ◽  
Cell Development ◽  
B Cell Development ◽  
Specific Cell ◽  
Cell Type ◽  
Specific Cell Type ◽  
Conditional Deletion

scholarly journals BCR Affinity Influences T-B Interactions and B Cell Development in Secondary Lymphoid Organs

2021 ◽  
Vol 12 ◽  
Author(s):  
Alec J. Wishnie ◽  
Tzippora Chwat-Edelstein ◽  
Mary Attaway ◽  
Bao Q. Vuong
Keyword(s):  
B Cells ◽  
B Cell ◽  
Cell Receptor ◽  
Cell Development ◽  
B Cell Development ◽  
Affinity Maturation ◽  
B Cell Receptor ◽  
Specific Cell ◽  
High Affinity ◽  
Tfh Cells

B cells produce high-affinity immunoglobulins (Igs), or antibodies, to eliminate foreign pathogens. Mature, naïve B cells expressing an antigen-specific cell surface Ig, or B cell receptor (BCR), are directed toward either an extrafollicular (EF) or germinal center (GC) response upon antigen binding. B cell interactions with CD4+ pre-T follicular helper (pre-Tfh) cells at the T-B border and effector Tfh cells in the B cell follicle and GC control B cell development in response to antigen. Here, we review recent studies demonstrating the role of B cell receptor (BCR) affinity in modulating T-B interactions and the subsequent differentiation of B cells in the EF and GC response. Overall, these studies demonstrate that B cells expressing high affinity BCRs preferentially differentiate into antibody secreting cells (ASCs) while those expressing low affinity BCRs undergo further affinity maturation or differentiate into memory B cells (MBCs).

Conditional deletion of mTOR discloses its essential role in early B‐cell development

2021 ◽  
Author(s):  
Shuling Zhang ◽  
Wendy Dubois ◽  
Xingmin Feng ◽  
Joe T. Nguyen ◽  
Neal S. Young ◽  
...  
Keyword(s):  
B Cell ◽  
Essential Role ◽  
Cell Development ◽  
B Cell Development ◽  
Conditional Deletion

Fetal B cell development

1997 ◽  
Vol 56 (1-3) ◽  
pp. 98 ◽  
Author(s):  
J Kearney
Keyword(s):  
B Cell ◽  
Cell Development ◽  
B Cell Development

Genetic Control of DH Reading Frame and Its Effect on B-Cell Development and Antigen-Specifc Antibody Production

2010 ◽  
Vol 30 (4) ◽  
pp. 327-344 ◽  
Author(s):  
Harry W. Schroeder, Jr. ◽  
Michael Zemlin ◽  
Mohamed Khass ◽  
Huan H. Nguyen ◽  
Robert L. Schelonka
Keyword(s):  
B Cell ◽  
Genetic Control ◽  
Antibody Production ◽  
Cell Development ◽  
B Cell Development ◽  
Reading Frame
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