scholarly journals Strontium Ranelate Reduces the Fracture Incidence in a Growing Mouse Model of Osteogenesis Imperfecta

2016 ◽  
Vol 31 (5) ◽  
pp. 1003-1014 ◽  
Author(s):  
Changgui Shi ◽  
Bo Hu ◽  
Lei Guo ◽  
Peng Cao ◽  
Ye Tian ◽  
...  
Keyword(s):  
Mouse Model ◽  
Osteogenesis Imperfecta ◽  
Strontium Ranelate ◽  
Fracture Incidence

Response to Comment on Strontium Ranelate Reduces the Fracture Incidence in a Growing Mouse Model of Osteogenesis Imperfecta

2016 ◽  
Vol 31 (11) ◽  
pp. 2066-2066
Author(s):  
Changgui Shi ◽  
Bo Hu ◽  
Lei Guo ◽  
Peng Cao ◽  
Ye Tian ◽  
...  
Keyword(s):  
Mouse Model ◽  
Osteogenesis Imperfecta ◽  
Strontium Ranelate ◽  
Fracture Incidence

scholarly journals Comparable Effects of Strontium Ranelate and Alendronate Treatment on Fracture Reduction in a Mouse Model of Osteogenesis Imperfecta

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Changgui Shi ◽  
Bin Sun ◽  
Chao Ma ◽  
Huiqiao Wu ◽  
Rui Chen ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Mouse Model ◽  
Bone Formation ◽  
Osteogenesis Imperfecta ◽  
Strontium Ranelate ◽  
Maximum Load ◽  
Inhibitory Effect ◽  
Comparable Efficacy ◽  
Mineral Density ◽  
Trabecular Bone Mineral Density

Alendronate (Aln) has been the first-line drug for osteogenesis imperfecta (OI), while the comparable efficacy of Aln and strontium ranelate (SrR) remains unclear. This study is aimed at comparing the effects of SrR and Aln treatment in a mouse model of OI. Three-week-old oim/oim and wt/wt female mice were treated with SrR (1800 mg/kg/day), Aln (0.21 mg/kg/week), or vehicle (Veh) for 11 weeks. After the treatment, the average number of fractures sustained per mouse was significantly reduced in both SrR- and Aln-treated oim/oim mice. The effect was comparable between these two agents. Both SrR and Aln significantly increased trabecular bone mineral density, bone histomorphometric parameters (bone volume, trabecular number, and cortical thickness and area), and biomechanical parameters (maximum load and stiffness) as compared with the Veh group. Both treatments reduced bone resorption parameters, with Aln demonstrating a stronger inhibitory effect than SrR. In contrast to its inhibitory effect on bone resorption, SrR maintained bone formation. Aln, however, also suppressed bone formation coupled with an inhibitory effect on bone resorption. The results of this study indicate that SrR has comparable effects with Aln on reducing fractures and improving bone mass and strength. In clinical practice, SrR may be considered an option for patients with OI when other medications are not suitable or have evident contraindications.

Bone Marrow Transplantation for Treatment of the Col1a2+/G610C Osteogenesis Imperfecta Mouse Model

2018 ◽  
Vol 104 (4) ◽  
pp. 426-436 ◽  
Author(s):  
Lucinda R. Lee ◽  
Lauren Peacock ◽  
Samantha L. Ginn ◽  
Laurence C. Cantrill ◽  
Tegan L. Cheng ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Mouse Model ◽  
Osteogenesis Imperfecta ◽  
Marrow Transplantation

scholarly journals Endoplasmic reticulum stress is induced in growth plate hypertrophic chondrocytes in G610C mouse model of osteogenesis imperfecta

2019 ◽  
Vol 509 (1) ◽  
pp. 235-240 ◽  
Author(s):  
Amanda L. Scheiber ◽  
Adam J. Guess ◽  
Takashi Kaito ◽  
Joshua M. Abzug ◽  
Motomi Enomoto-Iwamoto ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Mouse Model ◽  
Osteogenesis Imperfecta ◽  
Growth Plate ◽  
Hypertrophic Chondrocytes

scholarly journals 1025. Therapeutic Effect of a Self-Cleaving Hammerhead Ribozyme in a Mouse Model of Osteogenesis Imperfecta

2006 ◽  
Vol 13 ◽  
pp. S394
Author(s):  
Belinda E. Peace ◽  
Christopher J. Frede ◽  
Jane B. Florer ◽  
Michael W. Kilpatrick ◽  
Petros Tsipouras ◽  
...  
Keyword(s):  
Mouse Model ◽  
Osteogenesis Imperfecta ◽  
Therapeutic Effect ◽  
Hammerhead Ribozyme
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