scholarly journals Fracture Risk Is Decreased in Women With Polycystic Ovary Syndrome: A Register‐Based and Population‐Based Cohort Study

2015 ◽  
Vol 31 (4) ◽  
pp. 709-717 ◽  
Author(s):  
Katrine Hass Rubin ◽  
Dorte Glintborg ◽  
Mads Nybo ◽  
Marianne Andersen ◽  
Bo Abrahamsen
Keyword(s):  
Cohort Study ◽  
Polycystic Ovary Syndrome ◽  
Fracture Risk ◽  
Polycystic Ovary ◽  
Population Based ◽  
Ovary Syndrome

scholarly journals Trend of Cardio-Metabolic Risk Factors in Polycystic Ovary Syndrome: A Population-Based Prospective Cohort Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137609 ◽  
Author(s):  
Fahimeh Ramezani Tehrani ◽  
Seyed Ali Montazeri ◽  
Farhad Hosseinpanah ◽  
Leila Cheraghi ◽  
Hadi Erfani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Polycystic Ovary Syndrome ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Polycystic Ovary ◽  
Population Based ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Ovary Syndrome

scholarly journals Polycystic Ovary Syndrome, Combined Oral Contraceptives, and the Risk of Dysglycemia: A Population-Based Cohort Study With a Nested Pharmacoepidemiological Case-Control Study

2021 ◽  
Author(s):  
Balachandran Kumarendran ◽  
Michael W O'Reilly ◽  
Anuradhaa Subramanian ◽  
Dana Šumilo ◽  
Konstantinos Toulis ◽  
...  
Keyword(s):  
Cohort Study ◽  
Polycystic Ovary Syndrome ◽  
Oral Contraceptives ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Population Based ◽  
Case Control ◽  
Ovary Syndrome ◽  
Combined Oral Contraceptives ◽  
Control Study

<b>Objectives: </b>Irregular menstrual cycles are associated with increased cardiovascular mortality. Polycystic ovary syndrome (PCOS) is characterized by androgen excess and irregular menses; androgens are drivers of increased metabolic risk in women with PCOS. Combined oral contraceptives (COCPs) are used in PCOS both for cycle regulation and to reduce the biologically active androgen fraction. We examined COCP use and risk of dysglycemia (pre-diabetes and type 2 diabetes) in women with PCOS. <p><b>Research Design and Methods: </b>Utilizing a large UK primary care database (The Health Improvement Network, THIN; 3.7 million patients from 787 practices), we carried out a retrospective population-based cohort study to determine dysglycemia risk (64,051 women with PCOS, 123,545 matched controls), as well as a nested pharmaco-epidemiological case-control study to investigate COCP use in relation to dysglycemia risk (2407 women with PCOS with [=cases] and without [=controls] a diagnosis of dysglycemia during follow-up).<b> </b>Cox models were used to estimate the unadjusted and adjusted hazard ratio and conditional logistic regression was used to obtain adjusted odds ratios (aORs). </p> <p><b>Results: </b>The adjusted hazard ratio for dysglycemia in women with PCOS was 1.87 (95% CI 1.78-1.97, p<0.001; adjustment for age, social deprivation, BMI, ethnicity, and smoking), with increased rates of dysglycemia in all BMI subgroups. Women with PCOS and COCP use had a reduced dysglycemia risk (aOR 0.72, 95% CI 0.59 to 0.87).</p> <p><b>Conclusions: </b>In this study limited by its retrospective nature and the use of routinely collected electronic general practice record data, which does not allow to exclude the impact of prescription-by-indication bias, women<b> </b>with PCOS exposed to COCPs had a reduced risk of dysglycemia across all BMI subgroups. Future prospective studies should be considered to further understand these observations and potential causality. </p>

scholarly journals Hypertension Risk in Young Women With Polycystic Ovary Syndrome: A Nationwide Population-Based Cohort Study

2020 ◽  
Vol 7 ◽  
Author(s):  
Cheng-Hsuan Wu ◽  
Lu-Ting Chiu ◽  
Yu-Jun Chang ◽  
Chun-I Lee ◽  
Maw-Sheng Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Population Based ◽  
Ovary Syndrome ◽  
Hypertension Risk

The risk of chronic kidney disease among women with polycystic ovary syndrome: A long‐term population‐based cohort study

2020 ◽  
Vol 93 (5) ◽  
pp. 590-597
Author(s):  
Samira Behboudi‐Gandevani ◽  
Mina Amiri ◽  
Leila Cheraghi ◽  
Saber Amanollahi Soudmand ◽  
Fereidoun Azizi ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Population Based ◽  
Ovary Syndrome
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