scholarly journals In vivo discrimination of hip fracture with quantitative computed tomography: Results from the prospective European Femur Fracture Study (EFFECT)

2011 ◽  
Vol 26 (4) ◽  
pp. 881-893 ◽  
Author(s):  
Valérie Danielle Bousson ◽  
Judith Adams ◽  
Klaus Engelke ◽  
Mounir Aout ◽  
Martine Cohen-Solal ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Hip Fracture ◽  
Femur Fracture ◽  
Quantitative Computed Tomography ◽  
Fracture Study

scholarly journals Association of 3D Geometric Measures Derived From Quantitative Computed Tomography With Hip Fracture Risk in Older Men

2016 ◽  
Vol 31 (8) ◽  
pp. 1550-1558 ◽  
Author(s):  
Jan Borggrefe ◽  
Timm de Buhr ◽  
Smriti Shrestha ◽  
Lynn M Marshall ◽  
Eric Orwoll ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Quantitative Computed Tomography ◽  
Older Men ◽  
Hip Fracture Risk

scholarly journals Assessing bone mineral density in vivo: quantitative computed tomography

2004 ◽  
Vol 83 (2) ◽  
pp. 222-229 ◽  
Author(s):  
D.R. Korver ◽  
J.L. Saunders-Blades ◽  
K.L. Nadeau
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Quantitative Computed Tomography ◽  
Mineral Density

scholarly journals Longitudinal in Vivo Analysis of the Region-Specific Efficacy of Parathyroid Hormone in a Rat Cortical Defect Model

Endocrinology ◽  
2008 ◽  
Vol 150 (4) ◽  
pp. 1570-1579 ◽  
Author(s):  
David E. Komatsu ◽  
Kellie A. Brune ◽  
Hong Liu ◽  
Allen L. Schmidt ◽  
Bomie Han ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Healing ◽  
Quantitative Computed Tomography ◽  
Type I ◽  
Defect Model ◽  
Procollagen Type ◽  
Cortical Defect ◽  
Defect Sites ◽  
Procollagen Type I

PTH has been shown to enhance fracture repair; however, exactly when and where PTH acts in this process remains to be elucidated. Therefore, we conducted a longitudinal, region-specific analysis of bone regeneration in mature, osteopenic rats using a cortical defect model. Six-month-old rats were ovariectomized, and allowed to lose bone for 2 months, before being subjected to bilateral 2-mm circular defects in their femoral diaphyses. They were then treated for 5 wk with hPTH1–38 at doses of 0, 3, 10, or 30 μg/kg · d and scanned weekly by in vivo quantitative computed tomography. Quantitative computed tomography analyses showed temporal, dose-dependent increases in mineralization in the defects, intramedullary (IM) spaces, and whole diaphyses at the defect sites. Histomorphometry confirmed PTH stimulation of primarily woven bone in the defects and IM spaces, but not the periosteum. After necropsy, biomechanical testing identified an increase in strength at the highest PTH dose. Serum procollagen type I N-terminal propeptide concentration showed a transient increase due to drilling, but procollagen type I N-terminal propeptide also increased with PTH treatment, whereas tartrate-resistant acid phosphatase unexpectedly decreased. Analyses of lumber vertebra confirmed systemic efficacy of PTH at a nonfracture site. In summary, PTH dose dependently induced new bone formation within defects, at endocortical surfaces, and in IM spaces, resulting in faster and greater bone healing, as well as efficacy at other skeletal sites. The effects of PTH were kinetic, region specific, and most apparent at high doses that may not be entirely clinically relevant; therefore, clinical studies are necessary to clarify the therapeutic utility of PTH in bone healing.

In Vivo Measurement of Gadolinium Concentration in a Rat Glioma Model by Monochromatic Quantitative Computed Tomography

2004 ◽  
Vol 39 (7) ◽  
pp. 385-393 ◽  
Author(s):  
G??raldine Le Duc ◽  
St??phanie Corde ◽  
Anne-Marie Charvet ◽  
H??l??ne Elleaume ◽  
R??gine Farion ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Quantitative Computed Tomography ◽  
Gadolinium Concentration ◽  
Rat Glioma ◽  
In Vivo Measurement ◽  
Glioma Model
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