scholarly journals Novel EP4 Receptor Agonist-Bisphosphonate Conjugate Drug (C1) Promotes Bone Formation and Improves Vertebral Mechanical Properties in the Ovariectomized Rat Model of Postmenopausal Bone Loss

2015 ◽  
Vol 30 (4) ◽  
pp. 670-680 ◽  
Author(s):  
Careesa C Liu ◽  
Sally Hu ◽  
Gang Chen ◽  
John Georgiou ◽  
Steve Arns ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Loss ◽  
Bone Formation ◽  
Rat Model ◽  
Receptor Agonist ◽  
Postmenopausal Bone Loss ◽  
Ovariectomized Rat ◽  
Ep4 Receptor

In vivo effects of two novel ALN-EP4a conjugate drugs on bone in the ovariectomized rat model for reversing postmenopausal bone loss

2015 ◽  
Vol 27 (2) ◽  
pp. 797-808 ◽  
Author(s):  
S. Hu ◽  
C. C. Liu ◽  
G. Chen ◽  
T. Willett ◽  
R. N. Young ◽  
...  
Keyword(s):  
Bone Loss ◽  
Rat Model ◽  
Postmenopausal Bone Loss ◽  
Ovariectomized Rat ◽  
In Vivo Effects

scholarly journals Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation

2002 ◽  
Vol 99 (7) ◽  
pp. 4580-4585 ◽  
Author(s):  
K. Yoshida ◽  
H. Oida ◽  
T. Kobayashi ◽  
T. Maruyama ◽  
M. Tanaka ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Formation ◽  
Receptor Activation ◽  
Prostaglandin E ◽  
Ep4 Receptor ◽  
Prevention Of Bone Loss ◽  
Stimulation Of

scholarly journals Crataegus pinnatifida Bunge Inhibits RANKL-Induced Osteoclast Differentiation in RAW 264.7 Cells and Prevents Bone Loss in an Ovariectomized Rat Model

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Minsun Kim ◽  
MinBeom Kim ◽  
Jae-Hyun Kim ◽  
SooYeon Hong ◽  
Dong Hee Kim ◽  
...  
Keyword(s):  
Bone Loss ◽  
Rat Model ◽  
Osteoclast Differentiation ◽  
Ovariectomized Rat ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Mineral Density ◽  
Crataegus Pinnatifida

Osteoporosis is characterized by a decrease in bone microarchitecture with an increased risk of fracture. Long-term use of primary treatments, such as bisphosphonates and selective estrogen receptor modulators, results in various side effects. Therefore, it is necessary to develop alternative therapeutics derived from natural products. Crataegus pinnatifida Bunge (CPB) is a dried fruit used to treat diet-induced indigestion, loss of appetite, and diarrhea. However, research into the effects of CPB on osteoclast differentiation and osteoporosis is still limited. In vitro experiments were conducted to examine the effects of CPB on RANKL-induced osteoclast differentiation in RAW 264.7 cells. Moreover, we investigated the effects of CPB on bone loss in the femoral head in an ovariectomized rat model using microcomputed tomography. In vitro, tartrate-resistant acid phosphatase (TRAP) staining results showed the number of TRAP-positive cells, and TRAP activity significantly decreased following CPB treatment. CPB also significantly decreased pit formation. Furthermore, CPB inhibited osteoclast differentiation by suppressing NFATc1, and c-Fos expression. Moreover, CPB treatment inhibited osteoclast-related genes, such as Nfatc1, Ca2, Acp5, mmp9, CtsK, Oscar, and Atp6v0d2. In vivo, bone mineral density and structure model index were improved by administration of CPB. In conclusion, CPB prevented osteoclast differentiation in vitro and prevented bone loss in vivo. Therefore, CPB could be a potential alternative medicine for bone diseases, such as osteoporosis.

scholarly journals In Vivo Bone Effects of a Novel Bisphosphonate‐EP4a Conjugate Drug (C3) for Reversing Osteoporotic Bone Loss in an Ovariectomized Rat Model

JBMR Plus ◽  
2019 ◽  
Vol 3 (12) ◽  
Author(s):  
Zeeshan Sheikh ◽  
Gang Chen ◽  
Faik Al‐Jaf ◽  
Marion Thévenin ◽  
Kate Banks ◽  
...  
Keyword(s):  
Bone Loss ◽  
Rat Model ◽  
Ovariectomized Rat ◽  
Osteoporotic Bone

scholarly journals GLP-1 Receptor Agonist Treatment Increases Bone Formation and Prevents Bone Loss in Weight-Reduced Obese Women

2015 ◽  
Vol 100 (8) ◽  
pp. 2909-2917 ◽  
Author(s):  
Eva W. Iepsen ◽  
Julie R. Lundgren ◽  
Bolette Hartmann ◽  
Oluf Pedersen ◽  
Torben Hansen ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Formation ◽  
Receptor Agonist ◽  
Obese Women

Effects of trans-Resveratrol from Polygonum cuspidatum on Bone Loss Using the Ovariectomized Rat Model

2005 ◽  
Vol 8 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Z.P. Liu ◽  
W.X. Li ◽  
B. Yu ◽  
J. Huang ◽  
J. Sun ◽  
...  
Keyword(s):  
Bone Loss ◽  
Rat Model ◽  
Ovariectomized Rat ◽  
Polygonum Cuspidatum
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