scholarly journals Bone Mineral Density Changes Among Women Initiating Proton Pump Inhibitors or H2 Receptor Antagonists: A SWAN Cohort Study

2015 ◽  
Vol 30 (2) ◽  
pp. 232-239 ◽  
Author(s):  
Daniel H Solomon ◽  
Susan J Diem ◽  
Kristine Ruppert ◽  
Yin Juan Lian ◽  
Chih-Chin Liu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cohort Study ◽  
Bone Mineral ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Mineral Density ◽  
Receptor Antagonists ◽  
H2 Receptor Antagonists ◽  
H2 Receptor

scholarly journals Risk of Post-Myocardial Infarction Pneumonia with Proton Pump Inhibitors, H2 Receptor Antagonists and Mucoprotective Agents: A Retrospective Nationwide Cohort Study

2022 ◽  
Vol 12 (1) ◽  
pp. 78
Author(s):  
Jimin Jeon ◽  
Jinkwon Kim
Keyword(s):  
Myocardial Infarction ◽  
Cohort Study ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Time Dependent ◽  
Gi Bleeding ◽  
Receptor Antagonists ◽  
H2 Receptor Antagonists ◽  
H2 Receptor

Patients with myocardial infarction (MI) are at high risk of developing pneumonia. Proton pump inhibitors (PPI) and H2-receptor antagonists (H2RA) are commonly used acid-suppressive medications to the patients with MI for gastrointestinal (GI) protection, which may increase the risk for pneumonia. We evaluated whether PPI, H2RA, and mucoprotective agents without anti-acid properties increase the risk of post-MI pneumonia. We performed a retrospective cohort study based on the National Health Insurance Service—National Sample Cohort in Korea. The study included 3701 patients discharged with MI without prior history of pneumonia. During follow-up, treatments with PPI, H2RA, and mucoprotective agents were collected as time-dependent variables based on the prescription records. We performed multivariate time-dependent Cox regression analyses for the development of post-MI pneumonia. During the mean 4.85 ± 3.75 years follow-up, 999 participants developed pneumonia. In the multivariate analyses (adjusted hazard ratio; 95% confidence interval), the risk for pneumonia was significantly increased in treatment with PPI (2.25; 1.57–3.21) and H2RA (1.50; 1.16–1.93). Meanwhile, the risk for pneumonia was not increased in treatment with mucoprotective agents. When we evaluated GI bleeding event according to the medications as a secondary outcome analysis, mucoprotective agents were associated with increased GI bleeding risk, but PPI and H2RA were not. In the use of the GI medications in the treatment of patients with MI, the influence of these drugs on bleeding and pneumonia should be considered.

scholarly journals Prolonged Use of Proton Pump Inhibitors, but Not Histamine-2 Receptor Antagonists, Is Associated With Lower Bone Mineral Density in Males Aged Over 70

2021 ◽  
Vol 8 ◽  
Author(s):  
Shihua Gao ◽  
Wenting Song ◽  
Tianye Lin ◽  
Wenhuan Chen ◽  
Wei He ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Cross Sectional Study ◽  
Linear Regression Models ◽  
Mineral Density ◽  
Receptor Antagonists ◽  
Cross Sectional

Aims: The association of acid suppressants use with bone mineral density (BMD) is still unclear, especially in older adult with prolonged use of proton pump inhibitors (PPIs) or histamine-2 receptor antagonists (H2RAs). In this study, our aim was to investigate the association between PPI or H2RA use and BMD in general US older adults.Methods: We conducted a cross-sectional study on a sample from National Health and Nutrition Examination Survey. Association between long-term use of PPIs or H2RAs and lumber spine BMD in elderly was evaluated using weighted multivariate linear regression models. Sensitive and subgroup analysis were also performed in this study.Results: Long-term PPI use is correlated with lower lumber spine BMD in our multivariable regression model after adjusting for known confounding factors. Further analysis showed PPI use with a duration over 1 year was negatively associated with lumber spine BMD in male, elderly aged over 70 years, and white elderly. There is no significant association between long-term H2RA use and lumber spine BMD.Conclusions: Our results indicated that the association between long-term use of PPI and lumber spine BMD differed by gender. Long term use of PPIs would reduce lumber spine BMD in older men, while H2RA use is not significantly linked with lumber spine BMD. Patients that are at high risk of bone loss should shortened the duration of PPI use (<1 year) or use H2RAs as alternative if possible.

scholarly journals The Association Between Prolonged Proton Pump Inhibitors Use and Bone Mineral Density

2019 ◽  
Vol Volume 12 ◽  
pp. 349-355 ◽  
Author(s):  
Mohammad Reza Fattahi ◽  
Ramin Niknam ◽  
Mesbah Shams ◽  
Amir Anushiravani ◽  
Seyed Alireza Taghavi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Mineral Density
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