scholarly journals Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Prevents Osteopenia by Promoting Bone Formation and Suppressing Bone Resorption in Aged Ovariectomized Rats

2013 ◽  
Vol 28 (7) ◽  
pp. 1641-1652 ◽  
Author(s):  
Xue Ma ◽  
Jingru Meng ◽  
Min Jia ◽  
Long Bi ◽  
Ying Zhou ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Receptor Agonist ◽  
Ovariectomized Rats ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals The Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 Inhibits Lipopolysaccharide-Induced Osteoclast Formation and Bone Resorption via Inhibition of TNF-αExpression in Macrophages

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Wei-Ren Shen ◽  
Keisuke Kimura ◽  
Masahiko Ishida ◽  
Haruki Sugisawa ◽  
Akiko Kishikawa ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Mrna Expression ◽  
Receptor Agonist ◽  
Type I Collagen ◽  
Osteoclast Formation ◽  
Type I ◽  
Receptor Agonists ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Glucagon-like peptide-1 (GLP-1) receptor agonists are an effective treatment approach for type 2 diabetes. Recently, anti-inflammatory effects of GLP-1 receptor agonists have also been reported. Lipopolysaccharide (LPS) induces inflammation and osteoclast formation. In this study, we investigated the effect of exendin-4, a widely used GLP-1 receptor agonist, in LPS-induced osteoclast formation and bone resorption. LPS with or without exendin-4 was administered on mouse calvariae by daily subcutaneous injection. The number of osteoclasts, the ratio of bone resorption pits, and the level of C-terminal cross-linked telopeptide of type I collagen (CTX) were significantly lower in LPS- and exendin-4-coadministered mice than in mice administered with LPS alone. RANKL and TNF-αmRNA expression levels were lower in the exendin-4- and LPS-coadministered group than in the LPS-administered group. Ourin vitroresults showed no direct effects of exendin-4 on RANKL-induced osteoclast formation, TNF-α-induced osteoclast formation, or LPS-induced RANKL expression in stromal cells. Conversely, TNF-αmRNA expression was inhibited in the exendin-4- and LPS-cotreated macrophages compared with cells treated with LPS alone. These results indicate that the GLP-1 receptor agonist exendin-4 may inhibit LPS-induced osteoclast formation and bone resorption by inhibiting LPS-induced TNF-αproduction in macrophages.

scholarly journals Glucagon-like peptide-1 receptor agonist Liraglutide has anabolic bone effects in ovariectomized rats without diabetes.

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132744 ◽  
Author(s):  
Nan Lu ◽  
Hanxiao Sun ◽  
JingJia Yu ◽  
Xiaojing Wang ◽  
Dongmei Liu ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Ovariectomized Rats ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Dulaglutide, a glucagon-like peptide-1 receptor agonist: in the search for survival molecule

2020 ◽  
Vol 9 (2) ◽  
pp. 49-58
Author(s):  
A.S. Ametov ◽  
◽  
A.O. Nevolnikova ◽  
E.A. Tertychnaya ◽  
O.A. Mishra ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Liraglutide, a glucagon-like peptide-1 receptor agonist, improves bone mass and architecture in ovariectomised mice

2014 ◽  
Author(s):  
Marie Pereira ◽  
Jeshmi Jeyabalan ◽  
Camilla Sofie Jorgensen ◽  
Mark Cleasby ◽  
Mark Hopkinson ◽  
...  
Keyword(s):  
Bone Mass ◽  
Receptor Agonist ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Use of Big-Data Algorithms to Characterize Patients with T2D on Basal Insulin (BI) Who Add a Glucagon-Like Peptide-1 Receptor Agonist (GLP-1 RA) and Predict Their A1C Response

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 100-LB ◽  
Author(s):  
ESTHER ZIMMERMANN ◽  
ADAM LENART ◽  
JOAO DIOGO DA ROCHA FERNANDES ◽  
SARAH EGGERT ◽  
MATTIS F. RANTHE
Keyword(s):  
Big Data ◽  
Basal Insulin ◽  
Receptor Agonist ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Attenuates Prostate Cancer Cell Proliferation via Phosphorylation of MKP-1

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1957-P
Author(s):  
TAKAKO KAWANAMI ◽  
TAKASHI NOMIYAMA ◽  
YURIKO HAMAGUCHI ◽  
TOMOKO TANAKA ◽  
TOSHIHIKO YANASE
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Receptor Agonist ◽  
Prostate Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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