scholarly journals Targeted inhibition of T-cell factor activity promotes syndecan-2 expression and sensitization to doxorubicin in osteosarcoma cells and bone tumors in mice

2012 ◽  
Vol 27 (10) ◽  
pp. 2118-2129 ◽  
Author(s):  
François-Xavier Dieudonné ◽  
Allison Marion ◽  
Pierre J Marie ◽  
Dominique Modrowski
Keyword(s):  
T Cell ◽  
Bone Tumors ◽  
Factor Activity ◽  
Osteosarcoma Cells ◽  
T Cell Factor ◽  
Targeted Inhibition

scholarly journals Protein Kinase D1 attenuates tumorigenesis in colon cancer by modulating β-catenin/T cell factor activity

Oncotarget ◽  
2014 ◽  
Vol 5 (16) ◽  
pp. 6867-6884 ◽  
Author(s):  
Vasudha Sundram ◽  
Aditya Ganju ◽  
Joshua E. Hughes ◽  
Sheema Khan ◽  
Subhash C. Chauhan ◽  
...  
Keyword(s):  
Colon Cancer ◽  
T Cell ◽  
Protein Kinase ◽  
Factor Activity ◽  
Protein Kinase D1 ◽  
T Cell Factor

scholarly journals Interaction of FOXO with β-Catenin Inhibits β-Catenin/T Cell Factor Activity

2008 ◽  
Vol 283 (14) ◽  
pp. 9224-9230 ◽  
Author(s):  
Diana Hoogeboom ◽  
Marieke A. G. Essers ◽  
Paulien E. Polderman ◽  
Erik Voets ◽  
Lydia M. M. Smits ◽  
...  
Keyword(s):  
T Cell ◽  
Factor Activity ◽  
T Cell Factor

scholarly journals The Potential of T Cell Factor 1 in Sustaining CD8+ T Lymphocyte-Directed Anti-Tumor Immunity

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 515
Author(s):  
Sungmin Jung ◽  
Jea-Hyun Baek
Keyword(s):  
T Cell ◽  
Tumor Immunity ◽  
T Lymphocyte ◽  
Critical Role ◽  
Cd8 T Cell ◽  
Immune Checkpoint Blockade ◽  
Viral Escape ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
T Cell Factor

T cell factor 1 (TCF1) is a transcription factor that has been highlighted to play a critical role in the promotion of T cell proliferation and maintenance of cell stemness in the embryonic and CD8+ T cell populations. The regulatory nature of TCF1 in CD8+ T cells is of great significance, especially within the context of T cell exhaustion, which is linked to the tumor and viral escape in pathological contexts. Indeed, inhibitory signals, such as programmed cell death 1 (PD-1) and cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4), expressed on exhausted T lymphocytes (TEX), have become major therapeutic targets in immune checkpoint blockade (ICB) therapy. The significance of TCF1 in the sustenance of CTL-mediated immunity against pathogens and tumors, as well as its recently observed necessity for an effective anti-tumor immune response in ICB therapy, presents TCF1 as a potentially significant biomarker and/or therapeutic target for overcoming CD8+ T cell exhaustion and resistance to ICB therapy. In this review, we aim to outline the recent findings on the role of TCF1 in T cell development and discuss its implications in anti-tumor immunity.

scholarly journals Correction to: Forkhead box (FOX) G1 promotes hepatocellular carcinoma epithelial-Mesenchymal transition by activating Wnt signal through forming T-cell factor-4/Betacatenin/FOXG1 complex

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Xingrong Zheng ◽  
Jiaxin Lin ◽  
Hewei Wu ◽  
Zhishuo Mo ◽  
Yunwen Lian ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Cell ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
T Cell Factor ◽  
Forkhead Box ◽  
Wnt Signal

An amendment to this paper has been published and can be accessed via the original article.

T cell-induced normalization of transformed malignant fibroblasts: A lymphokine with normalization factor activity

1989 ◽  
Vol 108 (4) ◽  
pp. 1473-1476
Author(s):  
I. Ya. Stonans ◽  
N. K. Gorlina ◽  
A. N. Cheredeev ◽  
M. E. Bogdanov ◽  
O. A. Khoperskaya ◽  
...  
Keyword(s):  
T Cell ◽  
Factor Activity ◽  
Normalization Factor

Mouse CD11c+ B220+ Gr1+plasmacytoid dendritic cells develop independently of the T-cell lineage

Blood ◽  
2002 ◽  
Vol 100 (8) ◽  
pp. 2852-2857 ◽  
Author(s):  
Isabel Ferrero ◽  
Werner Held ◽  
Anne Wilson ◽  
Fabienne Tacchini-Cottier ◽  
Freddy Radtke ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Bone Marrow Cells ◽  
T Cell Development ◽  
Cell Lineage ◽  
Notch 1 ◽  
T Cell Factor ◽  
Plasmacytoid Dcs ◽  
Lineage Markers ◽  
Mixed Chimeras

The developmental origin of dendritic cells (DCs) is controversial. In the mouse CD8α+ and CD8α− DC subsets are often considered to be of lymphoid and myeloid origin respectively, although evidence on this point is conflicting. Very recently a novel CD11c+ B220+ DC subset has been identified that appears to be the murine counterpart to interferon alpha (IFNα)–producing human plasmacytoid DCs (PDCs). We show here that CD11c+ B220+ mouse PDCs, like human PDCs, are present in the thymus and express T lineage markers such as CD8α and CD4. However, the intrathymic development of PDCs can be completely dissociated from immature T lineage cells in mixed chimeras established with bone marrow cells from mice deficient for either Notch-1 or T-cell factor 1, two independent mutations that severely block early T-cell development. Our data indicate that thymic PDCs do not arise from a bipotential T/DC precursor.

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