Novel extraneural role of neurite outgrowth inhibitor A: Modulation of osteoclastogenesis via positive feedback regulation of nuclear factor of activated T cell cytoplasmic 1

2012 ◽  
Vol 27 (5) ◽  
pp. 1043-1054 ◽  
Author(s):  
Youngkyun Lee ◽  
Hyung Joon Kim ◽  
Cheol Kyu Park ◽  
Woo-Shin Kim ◽  
Zang Hee Lee ◽  
...  
Keyword(s):  
T Cell ◽  
Neurite Outgrowth ◽  
Positive Feedback ◽  
Feedback Regulation ◽  
Nuclear Factor ◽  
Activated T Cell

scholarly journals Role of the Ca2+-Calcineurin-Nuclear Factor of Activated T cell Pathway in Mitofusin-2-Mediated Immune Function of Jurkat Cells

2018 ◽  
Vol 131 (3) ◽  
pp. 330-338 ◽  
Author(s):  
Xiu-Ping Xu ◽  
Yong-Ming Yao ◽  
Guang-Ju Zhao ◽  
Zong-Sheng Wu ◽  
Jun-Cong Li ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Function ◽  
Jurkat Cells ◽  
Nuclear Factor ◽  
Mitofusin 2 ◽  
Activated T Cell

Role of Nuclear Factor of Activated T Cell (NFAT) Transcription Factors in Skin and Vascularized Cardiac Allograft Rejection

2011 ◽  
Vol 92 (5) ◽  
pp. e26-e27 ◽  
Author(s):  
Takuya Ueno ◽  
Akira Yamada ◽  
Toshiro Ito ◽  
Melissa Y. Yeung ◽  
Rostic Gorbatov ◽  
...  
Keyword(s):  
Transcription Factors ◽  
T Cell ◽  
Allograft Rejection ◽  
Cardiac Allograft ◽  
Nuclear Factor ◽  
Cardiac Allograft Rejection ◽  
Activated T Cell

scholarly journals The expression of nuclear factor of activated T cell c1 and receptor activator of nuclear factor kappa β induced by Enterococcus faecalis in osteoclastogenesis (laboratory experiment on Wistar rats)

2019 ◽  
Vol 52 (4) ◽  
pp. 172
Author(s):  
Nirawati Pribadi ◽  
Rosita Rahmawati ◽  
Mandojo Rukmo ◽  
Adelina Kristanti Tandadjaja ◽  
Hendy Jaya Kurniawan ◽  
...  
Keyword(s):  
T Cell ◽  
Enterococcus Faecalis ◽  
Wistar Rats ◽  
Bone Defects ◽  
Control Group ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Endodontic Infection ◽  
Receptor Activator ◽  
Activated T Cell

Background: Enterococcus faecalis (E. faecalis) is the most common bacteria species in persistent endodontic infection of teeth undergoing root canal treatment at a prevalence of 38%. The virulence factor of this bacterium is Lipoteichoic acid (LTA) which can be recognized by Toll-like receptors-4 (TLR-4) that produce a stimulus and provoke an immune response. Inflammation results in bone defects that feature multiple cytokines and interactions between different cell types. Bone loss within a periapical tooth is characterized by osteoclast formation (osteoclastogenesis) in the bone. Purpose: This study aimed to determine the expression of nuclear factor of activated T cell c1 (NFATc1) and receptor activator of nuclear factor kappa β (RANK) which played a role in osteoclastogenesis at different time intervals. Methods: 36 upper molar teeth of the research subjects were induced with 106 CFU Enterococcus faecalis and subsequently observed for 7 and 21 days with the NFATc1 and RANK being counted microscopically at 1000X magnification across 20 viewing fields. Thereafter, the data was examined and analyzed by means of an independent T test using SPSS. Results: NFATc1 and RANK expression were higher in the group including E. faecalis on days 7 and 21 than in the control group. There were significant differences between the treatment group and control group with regard to NFATc1 and RANK expression (p<0.05). Conclusion: The study showed that the expression of NFATc1 and RANK, which plays a role in osteoclastogenesis, was higher in periapical bone defects in Wistar rats induced by E. faecalis than those which were not induced.

scholarly journals A Conserved Calcineurin-binding Motif in Human T Lymphotropic Virus Type 1 p12IFunctions to Modulate Nuclear Factor of Activated T Cell Activation

2003 ◽  
Vol 278 (18) ◽  
pp. 15550-15557 ◽  
Author(s):  
Seung-jae Kim ◽  
Wei Ding ◽  
Björn Albrecht ◽  
Patrick L. Green ◽  
Michael D. Lairmore
Keyword(s):  
T Cell ◽  
Virus Type ◽  
T Cell Activation ◽  
Cell Activation ◽  
Binding Motif ◽  
Nuclear Factor ◽  
T Lymphotropic Virus ◽  
Activated T Cell

Tacrolimus and ascomycin inhibit melanoma cell growth, migration and invasion via targeting nuclear factor of activated T-cell 3

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Tian Xiao ◽  
Wencong Chen ◽  
Shuangfeng Wang ◽  
Shiying Huang ◽  
Chengyao Chiang ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Growth ◽  
Melanoma Cell ◽  
Migration And Invasion ◽  
Nuclear Factor ◽  
Activated T Cell

scholarly journals Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor κB in Regulating Mature T Cell Survival and In Vivo Function

2003 ◽  
Vol 197 (7) ◽  
pp. 861-874 ◽  
Author(s):  
Ye Zheng ◽  
Monika Vig ◽  
Jesse Lyons ◽  
Luk Van Parijs ◽  
Amer A. Beg
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Survival ◽  
Cd4 T Cells ◽  
Cell Function ◽  
Nuclear Factor ◽  
T Cell Function ◽  
T Cell Survival

Signaling pathways involved in regulating T cell proliferation and survival are not well understood. Here we have investigated a possible role of the nuclear factor (NF)-κB pathway in regulating mature T cell function by using CD4+ T cells from p50−/− cRel−/− mice, which exhibit virtually no inducible κB site binding activity. Studies with these mice indicate an essential role of T cell receptor (TCR)-induced NF-κB in regulating interleukin (IL)-2 expression, cell cycle entry, and survival of T cells. Our results further indicate that NF-κB regulates TCR-induced expression of antiapoptotic Bcl-2 family members. Strikingly, retroviral transduction of CD4+ T cells with the NF-κB–inducing IκB kinase β showed that NF-κB activation is not only necessary but also sufficient for T cell survival. In contrast, our results indicate a lack of involvement of NF-κB in both IL-2 and Akt-induced survival pathways. In vivo, p50−/− cRel−/− mice showed impaired superantigen-induced T cell responses as well as decreased numbers of effector/memory and regulatory CD4+ T cells. These findings provide the first demonstration of a role for NF-κB proteins in regulating T cell function in vivo and establish a critically important function of NF-κB in TCR-induced regulation of survival.

Nuclear Factor of Activated T Cell Mediates Proinflammatory Gene Expression in Response to Mechanotransduction

2007 ◽  
Vol 1117 (1) ◽  
pp. 138-142 ◽  
Author(s):  
A. B. CELIL AYDEMIR ◽  
S. LEE ◽  
D. WON KIM ◽  
T. R. GARDNER ◽  
D. PRINCE ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
Nuclear Factor ◽  
Activated T Cell ◽  
Proinflammatory Gene ◽  
Proinflammatory Gene Expression
Sign in / Sign up

Export Citation Format

Share Document