scholarly journals Pore‐size distribution and frequency‐dependent attenuation in human cortical tibia bone discriminate fragility fractures in postmenopausal women with low bone mineral density

JBMR Plus ◽  
2021 ◽  
Author(s):  
Gabriele Armbrecht ◽  
Huong Nguyen Minh ◽  
Jonas Massmann ◽  
Kay Raum
Keyword(s):  
Bone Mineral Density ◽  
Pore Size Distribution ◽  
Pore Size ◽  
Postmenopausal Women ◽  
Size Distribution ◽  
Bone Mineral ◽  
Fragility Fractures ◽  
Mineral Density ◽  
Frequency Dependent ◽  
Tibia Bone

scholarly journals Cortical pore size distribution and viscoelastic tibia properties discriminate fragility fractures independent of bone mineral density

2021 ◽  
Author(s):  
Kay Raum ◽  
Gabriele Armbrecht ◽  
Huong Minh ◽  
Jonas Massmann
Keyword(s):  
Bone Mineral Density ◽  
Pore Size Distribution ◽  
Pore Size ◽  
Size Distribution ◽  
Bone Mineral ◽  
Discrimination Performance ◽  
Areal Bone Mineral Density ◽  
Mineral Density ◽  
Structural Deterioration ◽  
Bone Properties

Abstract Osteoporosis is a disorder of bone remodeling leading to reduced bone mass, structural deterioration, and increased bone fragility. The established diagnosis is based on the measurement of areal bone mineral density by dual energy x-ray absorptiometry (DXA), which poorly captures individual bone loss and structural decay. Enlarged cortical pores in the tibia have been proposed to indicate structural deterioration and reduced bone strength in the hip. Here, we report for the first time the in-vivo assessment of the cortical pore size distribution together with viscoelastic bone properties by means of a novel ultrasonic cortical backscatter (CortBS) technology to discriminate between fractured and nonfractured postmenopausal women (N = 55). The discrimination performance was benchmarked with DXA and high-resolution peripheral computed tomography (HR-pQCT). The results suggest a superior discrimination performance of CortBS (area under the receiver operating characteristic curve: 0.69 ≤ AUC ≤ 0.75) compared to DXA (0.53 ≤ AUC ≤ 0.55) and a similar performance compared to HR-pQCT (0.68 ≤ AUC ≤ 0.73).

scholarly journals Calcium-sensing receptor gene polymorphism is not associated with bone mineral density in Italian postmenopausal women

2003 ◽  
pp. 603-607 ◽  
Author(s):  
F Cetani ◽  
E Pardi ◽  
S Borsari ◽  
E Vignali ◽  
G Dipollina ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Receptor Gene ◽  
Osteoporotic Fractures ◽  
Fragility Fractures ◽  
Mineral Density ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Significant Difference

OBJECTIVE: Calcium-sensing receptor (CaR) is a candidate gene for osteoporosis susceptibility. Several CaR polymorphisms have been identified and an association between the A986S genotype and serum calcium levels has been found in Canadian postmenopausal women. We investigated whether the presence of 986S allele was associated with bone mineral density (BMD) and osteoporotic fractures. DESIGN: The study group consisted of 164 Italian postmenopausal women without fragility fracture (Fx(-)) and 55 women with fracture (Fx(+)). METHODS: A fragment of exon 7 of CaR gene containing three polymorphisms (A986S, R990G and Q1011E) was amplified by PCR and sequenced. Anthropometric characteristics and BMD were evaluated. RESULTS: The A986S polymorphism was the most commonly observed (27.9%), whereas the other two CaR polymorphisms, R990G and Q1011E, occurred in a minority of cases (8.8 and 5.5% respectively). There was no significant difference in the frequency distribution of any CaR allele between Fx(-) and Fx(+) patients. Body mass index was found to predict BMD at the lumbar spine and femoral neck. The A986S polymorphism and Years since menopause were not independent predictors of BMD at any site. As far as fracture occurrence, there was no statistically significant difference in the prevalence of fractures between women carrying or not carrying the 986S allele. CONCLUSIONS: Our data do not support a role of A986S CaR polymorphism in BMD and in the prevalence of fragility fractures in Italian postmenopausal women.

Body composition and bone mineral density in postmenopausal women

2014 ◽  
Author(s):  
Vladyslav Povoroznyuk ◽  
Nataliia Dzerovych ◽  
Roksolana Povoroznyuk
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density
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