scholarly journals Increase in C‐Reactive Protein Predicts Increase in Rate of Bone Mineral Density Loss: the Study of Women's Health Across the Nation

JBMR Plus ◽  
2021 ◽  
Author(s):  
Gail A. Greendale ◽  
Nicholas J Jackson ◽  
Weijuan Han ◽  
MeiHua Huang ◽  
Jane A. Cauley ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Women’S Health ◽  
Women's Health ◽  
Bone Mineral ◽  
C Reactive Protein ◽  
Mineral Density ◽  
Bone Mineral Density Loss ◽  
Reactive Protein

scholarly journals POS0841 RISK FACTORS OF LOW BONE MINERAL DENSITY IN WOMEN WITH SYSTEMIC SCLEROSIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 674.2-675
Author(s):  
A. Efremova ◽  
N. Toroptsova ◽  
N. Demin ◽  
O. Dobrovolskaya ◽  
O. Nikitinskaya
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Systemic Sclerosis ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Cumulative Dose ◽  
Premenopausal Women ◽  
C Reactive Protein ◽  
Mineral Density ◽  
Reactive Protein

Background:Chronic inflammatory rheumatic diseases are risk factors of bone loss and fractures. Systemic sclerosis (SSc) has been recognized to be another potential inflammatory joint disease that may affect bone tissue.Objectives:to evaluate bone mineral density (BMD) and risk factors of low BMD in women with SSc.Methods:173 women, among them 110 postmenopausal (median age 60[55,63] years) and 63 premenopausal (median age 35[31,44] years). BMD was measured at lumbar spine (LS), femoral neck (FN) and total hip (TH) by dual energy X-ray absorptiometry (DXA, Hologic 4500A). Low BMD was diagnosed if the T-score was < -1.0 standard deviation (SD) in postmenopausal women and if the Z-score was < -2.0 SD in premenopausal women. The relationship between BMD and SSc patients’ characteristics was evaluated using univariate linear regression analysis.Results:Low BMD was found in 66% patients: 79% - in postmenopausal and 18% - in premenopausal women. Among postmenopausal persons osteoporosis was discovered in 47% and osteopenia – in 32% cases. In postmenopausal woman BMD of LS, FN and TH were associated with body mass index (BMI) (β=0.27, p=0.010; β=0.47, p<0,001 and β=0.45, p<0,001, respectively), duration of glucocorticoids (GCs) using (β=-0.31, p=0.008; β=-0.34, p=0.003 and β=-0.27, p=0.022, respectively); BMD of FN and TH with C-reactive protein (β= -0.32, p=0.016 and β= -0.29, p=0.029, respectively) and LS BMD with current and cumulative GCs dose (β= -0.24, p=0.039 and β= -0.29, p=0.014, respectively). In premenopausal women BMD of LS, FN and TH were associated with BMI (β=0.51, p<0,001; β=0.45, p=0.003 and β=0.47, p=0.002, respectively), duration of GCs using (β= -0.45, p=0.004; β= -0.47, p=0.003 and β= -0.48, p=0.002, respectively) and GCs cumulative dose (β= -0.48, p=0.002; β= -0.51, p=0.001 and β= -0.46, p=0.004, respectively); BMD of FN and TH with 25(ОН)D level (β=0.52, p=0.008 and β=0.54, p=0.005, respectively), and LS BMD with SSc duration (β= -0.44, p=0.004).Conclusion:Low BMD was diagnosed in 66% of women with SSc. Low BMI, GCs cumulative dose and duration of GCs using were independent risk factors for low BMD in both premenopausal and postmenopausal persons. Additional factors as SSc duration and low vitamin D level were found out for premenopausal and current GCs dose and C-reactive protein level for postmenopausal women.Disclosure of Interests:None declared

scholarly journals Dietary Soy Isoflavones and Bone Mineral Density: Results from the Study of Women's Health Across the Nation

2002 ◽  
Vol 155 (8) ◽  
pp. 746-754 ◽  
Author(s):  
G. A. Greendale ◽  
G. FitzGerald ◽  
M.-H. Huang ◽  
B. Sternfeld ◽  
E. Gold ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Women’S Health ◽  
Women's Health ◽  
Bone Mineral ◽  
Soy Isoflavones ◽  
Mineral Density ◽  
Density Results

The Association Between Mammographic Breast Density and Bone Mineral Density in the Study of Women's Health Across the Nation

2007 ◽  
Vol 17 (8) ◽  
pp. 575-583 ◽  
Author(s):  
Carolyn J. Crandall ◽  
Yan Zheng ◽  
Arun Karlamangla ◽  
Barbara Sternfeld ◽  
Laurel A. Habel ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Women’S Health ◽  
Women's Health ◽  
Bone Mineral ◽  
Breast Density ◽  
Mammographic Breast Density ◽  
Mineral Density

scholarly journals DISORDERS OF STRUCTURAL AND FUNCTIONAL STATE OF BONE TISSUE IN MEN WITH ANKYLOSING SPONDYLITIS, THEIR RELATION TO DISEASE COURSE

2021 ◽  
Vol 74 (8) ◽  
pp. 1856-1862
Author(s):  
Sergii Shevchuk ◽  
Oksanа Pavliuk
Keyword(s):  
Bone Mineral Density ◽  
Ankylosing Spondylitis ◽  
Bone Tissue ◽  
Bone Mineral ◽  
Functional State ◽  
Cumulative Dose ◽  
Inflammatory Process ◽  
C Reactive Protein ◽  
Mineral Density ◽  
Reactive Protein

The aim: To study the structural and functional state of bone tissue in men with ankylosing spondylitis and to asses its relationship with the course of the disease. Materials and methods: the study was conducted involving 105 men, aged 40.74 ± 0.87 years and 25 generally healthy individuals of the certain age and sex, who formed the control group. The functional ability was assessed by the BASFI index and the disease activity was calculated by ASDAS-CRP and BASDAI. Laboratory criteria for the activity of the inflammatory process were considered erythrocyte sedimentation rate and C-reactive protein. Bone mineral density of the lumbar spine and femoral neck was determined by dual energy X-ray absorptiometry. Results: osteoporosis and osteopenic syndrome were identified in men with ankylosing spondylitis in 27,7% and 29,5% consequently. Disorder of the structural and functional state of bone tissue was closely related to the total indicators of inflammatory activity in ASDAS-CRP (r = –0,36), BASDAI (r = –0,51), the functional index BASFI (r = –0,30), C-reactive protein (r = –0,30) and the cumulative dose of glucocorticoids (r = –0.32). The comparative analysis of densitometric parameters in groups of patients depending on the form of the disease has not shown statistically significant differences. Conclusions: The decrease in bone mineral density in patients with ankylosing spondylitis does not depend on age and duration of the disease, but is associated with the cumulative dose of glucocorticoids and high activity of the inflammatory process.

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