scholarly journals Osteoporosis Treatments Affect Bone Matrix Maturation in a Rat Model of Induced Cortical Remodeling

JBMR Plus ◽  
2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Ryan D Ross ◽  
Kyle Anderson ◽  
Reid Davison ◽  
Bilal M El‐Masri ◽  
Christina M Andreasen ◽  
...  
Keyword(s):  
Rat Model ◽  
Bone Matrix ◽  
Matrix Maturation

Maspin Is Involved in Bone Matrix Maturation by Enhancing the Accumulation of Latent TGF-β

2007 ◽  
Vol 22 (10) ◽  
pp. 1581-1591 ◽  
Author(s):  
Reiko Tokuyama ◽  
Kazuhito Satomura ◽  
Eriko Maeda ◽  
Keiko Kudoh ◽  
Yasuhumi Yamasaki ◽  
...  
Keyword(s):  
Bone Matrix ◽  
Matrix Maturation

Three years of treatment with once-yearly zoledronic acid influences the kinetics of bone matrix maturation in osteoporotic patients independent of bone turnover

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S78-S79
Author(s):  
S. Gamsjaeger ◽  
B. Buchinger ◽  
J. Gasser ◽  
E.F. Eriksen ◽  
K. Klaushofer ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Bone Turnover ◽  
Bone Matrix ◽  
Matrix Maturation ◽  
Kinetics Of

scholarly journals The Role of Extracellular Matrix Components in Dentin Mineralization

1991 ◽  
Vol 2 (3) ◽  
pp. 369-387 ◽  
Author(s):  
Adele L. Boskey
Keyword(s):  
Extracellular Matrix ◽  
Current Knowledge ◽  
Bone Matrix ◽  
Matrix Proteins ◽  
Crystal Formation ◽  
Extracellular Matrix Components ◽  
Dentin Mineralization ◽  
Matrix Maturation ◽  
Cell Matrix Interactions

The extracellular matrix of dentin consists of mineral (hydroxyapatite), collagen, and several noncollagenous matrix proteins. These noncollagenous matrix proteins may be mediators of cell-matrix interactions, matrix maturation, and mineralization. This review describes the current knowledge of the chemistry of mineral crystal formation in dentin with special emphasis on the roles of the dentin matrix proteins. The functions of some of these matrix proteins in the mineralization process have been deduced based on in vitro studies. Functions for others have been postulated based on analogy with some of the bone matrix proteins. Evidence suggests that several of these matrix proteins may have multiple effects on nucleation, crystal growth, and orientation of dentin hydroxyapatite.

scholarly journals Thrombospondins 1 and 2 affect lysyl oxidase protein and collagen matrix maturation in cortical bone of growing male and female mice via non-redundant pathways

2018 ◽  
Author(s):  
Dylan Shearer ◽  
Madison O Mervis ◽  
Eugene Manley ◽  
Anita B Reddy ◽  
Andrea I Alford
Keyword(s):  
Cortical Bone ◽  
Lysyl Oxidase ◽  
Bone Matrix ◽  
Collagen Matrix ◽  
Serum Starvation ◽  
Hydroxyproline Content ◽  
Male And Female ◽  
Total Signal ◽  
Female Mice ◽  
Matrix Maturation

AbstractThrombospondin-2-deficiency is associated with impaired matrix maturation in osteoblasts and cortical bone of growing mice. Here we addressed the possibility that lysyl oxidase (LOX) contributes to this phenotype. After overnight serum starvation, pro-LOX levels were elevated compared to wild-type in marrow-derived osteoblasts from male and female TSP2−/− mice. The liberated LOX pro-peptide (LOPP) was faintly visible in serum-starved cultures. When serum was maintained, pro-LOX content was not affected by TSP2 status, but relative LOPP levels were elevated in cultures from female TSP2−/− mice. Two isoforms of pro-LOX at 75 kDa and 50 kDa were detected in detergent soluble protein extracts of diaphyseal tissue from growing mice. In female mice, TSP2 status did not affect detergent soluble pro-LOX content or the relative contribution of each band to the total signal. Instead, levels of the 50 kDa band were reduced in female TSP1−/− samples. In male diaphyseal tissue, total pro-LOX content and the contribution each isoform made to the total signal was not affected by TSP1 or TSP2 status. We did not detect 32 kDa mature LOX in detergent soluble preparations of cells or whole bone tissue. Detergent insoluble hydroxyproline content was reduced in diaphyseal tissue obtained from female TSP1−/− and TSP2−/− mice. In male diaphyseal cortical samples, TSP2 but not TSP1 deficiency was associated with reduced insoluble hydroxyproline content. Our data suggest that the trimeric thrombospondins contribute to bone matrix quality via non-redundant mechanisms that are dependent on the unique tissue milieu of the male and female skeleton.

scholarly journals Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model

2014 ◽  
Vol 10 (11) ◽  
pp. 4574-4582 ◽  
Author(s):  
Lucas A. Kinard ◽  
Rebecca L. Dahlin ◽  
Johnny Lam ◽  
Steven Lu ◽  
Esther J. Lee ◽  
...  
Keyword(s):  
Rat Model ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Bone Augmentation ◽  
Biodegradable Hydrogel ◽  
Demineralized Bone

Effects of 3 years treatment with once-yearly zoledronic acid on the kinetics of bone matrix maturation in osteoporotic patients

2012 ◽  
Vol 24 (1) ◽  
pp. 339-347 ◽  
Author(s):  
S. Gamsjaeger ◽  
B. Hofstetter ◽  
E. Zwettler ◽  
R. Recker ◽  
J. A. Gasser ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Bone Matrix ◽  
Matrix Maturation ◽  
Kinetics Of

Femoral bone matrix mineralization is not altered in a rat model of type 2 diabetes mellitus

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S180-S181
Author(s):  
N. Fratzl-Zelman ◽  
P. Roschger ◽  
S. Lueger ◽  
K.-P. Guenther ◽  
C. Goettsch ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Rat Model ◽  
Bone Matrix ◽  
Femoral Bone ◽  
Matrix Mineralization ◽  
Bone Matrix Mineralization
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