scholarly journals Sclerostin Antibody Treatment Stimulates Bone Formation to Normalize Bone Mass in Male Down Syndrome Mice

JBMR Plus ◽  
2017 ◽  
Vol 2 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Diarra K Williams ◽  
Sean G Parham ◽  
Eric Schryver ◽  
Nisreen S Akel ◽  
R Shane Shelton ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Bone Formation ◽  
Bone Mass ◽  
Antibody Treatment ◽  
Sclerostin Antibody

scholarly journals Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis*

2009 ◽  
Vol 24 (4) ◽  
pp. 578-588 ◽  
Author(s):  
Xiaodong Li ◽  
Michael S Ominsky ◽  
Kelly S Warmington ◽  
Sean Morony ◽  
Jianhua Gong ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Postmenopausal Osteoporosis ◽  
Bone Strength ◽  
Rat Model ◽  
Antibody Treatment ◽  
Sclerostin Antibody

scholarly journals Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass and Bone Strength of Intact Bones in Adult Male Rats

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Pui Kit Suen ◽  
Tracy Y. Zhu ◽  
Dick Ho Kiu Chow ◽  
Le Huang ◽  
Li-Zhen Zheng ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Bone Strength ◽  
Adult Male ◽  
Male Rats ◽  
Antibody Treatment ◽  
Sclerostin Antibody

Sclerostin antibody improves phosphate metabolism hormones, bone formation rates, and bone mass in adult Hyp mice

Bone ◽  
2021 ◽  
pp. 116201
Author(s):  
Kelsey A. Carpenter ◽  
Reid Davison ◽  
Shruti Shakthivel ◽  
Kyle D. Anderson ◽  
Frank C. Ko ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Phosphate Metabolism ◽  
Sclerostin Antibody

scholarly journals Twist1 Inactivation in Dmp1-Expressing Cells Increases Bone Mass but Does Not Affect the Anabolic Response to Sclerostin Neutralization

2019 ◽  
Vol 20 (18) ◽  
pp. 4427 ◽  
Author(s):  
Karl J. Lewis ◽  
Roy B-J Choi ◽  
Emily Z. Pemberton ◽  
Whitney A. Bullock ◽  
Anthony B. Firulli ◽  
...  
Keyword(s):  
Bone Mass ◽  
Late Stage ◽  
Self Regulation ◽  
Biomechanical Properties ◽  
Loss Of Function ◽  
Antibody Treatment ◽  
Anabolic Response ◽  
Osteoblast Activity ◽  
Bone Properties ◽  
Sclerostin Antibody

Wnt signaling plays a major role in bone metabolism. Advances in our understanding of secreted regulators of Wnt have yielded several therapeutic targets to stimulate osteoanabolism—the most promising of which is the Wnt inhibitor sclerostin. Sclerostin antibody recently gained approval for clinical use to treat osteoporosis, but the biology surrounding sclerostin antagonism is still incompletely understood. Numerous factors regulate the efficacy of sclerostin inhibition on bone formation, a process known as self-regulation. In previous communications we reported that the basic helix-loop-helix transcription factor Twist1—a gene know to regulate skeletal development—is highly upregulated among the osteocyte cell population in mice treated with sclerostin antibody. In this communication, we tested the hypothesis that preventing Twist1 upregulation by deletion of Twist1 from late-stage osteoblasts and osteocytes would increase the efficacy of sclerostin antibody treatment, since Twist1 is known to restrain osteoblast activity in many models. Twist1-floxed loss-of-function mice were crossed to the Dmp1-Cre driver to delete Twist1 in Dmp1-expressing cells. Conditional Twist1 deletion was associated with a mild but significant increase in bone mass, as assessed by dual energy x-ray absorptiometry (DXA) and microCT (µCT) for many endpoints in both male and female mice. Biomechanical properties of the femur were not affected by conditional mutation of Twist1. Sclerostin antibody improved all bone properties significantly, regardless of Twist1 status, sex, or endpoint examined. No interactions were detected when Twist1 status and antibody treatment were examined together, suggesting that Twist1 upregulation in the osteocyte population is not an endogenous mechanism that restrains the osteoanabolic effect of sclerostin antibody treatment. In summary, Twist1 inhibition in the late-stage osteoblast/osteocyte increases bone mass but does not affect the anabolic response to sclerostin neutralization.

Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus

2013 ◽  
Vol 28 (3) ◽  
pp. 627-638 ◽  
Author(s):  
Christine Hamann ◽  
Martina Rauner ◽  
Yvonne Höhna ◽  
Ricardo Bernhardt ◽  
Jan Mettelsiefen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Mass ◽  
Bone Strength ◽  
Bone Defect ◽  
Antibody Treatment ◽  
Sclerostin Antibody
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