Targeted delivery of paclitaxel by NL2 peptide‐functionalized on core‐shell LaVO4 : Eu3@ poly (levodopa) luminescent nanoparticles

2021 ◽  
Author(s):  
Hamid Hashemi‐Moghaddam ◽  
Mansore Ebrahimi ◽  
Behrooz Johari ◽  
Hamid Madanchi
Keyword(s):  
Targeted Delivery ◽  
Core Shell ◽  
Luminescent Nanoparticles

scholarly journals Surface functionalisation of poly-APO-b-polyol ester cross-linked copolymers as core–shell nanoparticles for targeted breast cancer therapy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Rida Tajau ◽  
Rosiah Rohani ◽  
Siti Selina Abdul Hamid ◽  
Zainah Adam ◽  
Siti Najila Mohd Janib ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Particle Diameter ◽  
Core Shell ◽  
Breast Cancer Therapy ◽  
Polyol Ester ◽  
Apo B ◽  
Chemical Structures

AbstractPolymeric nanoparticles (NPs) are commonly used as nanocarriers for drug delivery, whereby their sizes can be altered for a more efficient delivery of therapeutic active agents with better efficacy. In this work, cross-linked copolymers acted as core–shell NPs from acrylated palm olein (APO) with polyol ester were synthesized via gamma radiation-induced reversible addition-fragmentation chain transfer (RAFT) polymerisation. The particle diameter of the copolymerised poly(APO-b-polyol ester) core–shell NPs was found to be less than 300 nm, have a low molecular weight (MW) of around 24 kDa, and showed a controlled MW distribution of a narrow polydispersity index (PDI) of 1.01. These properties were particularly crucial for further use in designing targeted NPs, with inclusion of peptide for the targeted delivery of paclitaxel. Moreover, the characterisation of the synthesised NPs using Fourier Transform-Infrared (FTIR) and Neutron Magnetic Resonance (NMR) analyses confirmed the possession of biodegradable hydrolysed ester in its chemical structures. Therefore, it can be concluded that the synthesised NPs produced may potentially contribute to better development of a nano-structured drug delivery system for breast cancer therapy.

PLGA-lecithin-PEG-folate core–shell nanoparticles for cisplatin-prodrug targeted delivery

2016 ◽  
Vol 12 (2) ◽  
pp. 539
Author(s):  
Mingbin Zheng ◽  
Ping Gong ◽  
Dongxue Jia ◽  
Yangyang Lu ◽  
Cuifang Zheng ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

scholarly journals Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain

2016 ◽  
Vol 1 (5) ◽  
pp. 407-414 ◽  
Author(s):  
Jinmyoung Joo ◽  
Ester J. Kwon ◽  
Jinyoung Kang ◽  
Matthew Skalak ◽  
Emily J. Anglin ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Porous Silicon ◽  
Gene Silencing ◽  
Targeted Delivery ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Injured Brain ◽  
Core Shell Nanoparticles

A chemically targeted luminescent porous silicon–graphene oxide core–shell nanoparticle delivers siRNA for more effective gene silencing.

scholarly journals Reversible Multilayered Vesicle-like Structures with Fluid Hydrophobic and Interpolyelectrolyte Layers

2020 ◽  
Author(s):  
Anastasiia Murmiliuk ◽  
Sergey K. Filippov ◽  
Oleg Rud ◽  
Peter Košovan ◽  
Zdeněk Tošner ◽  
...  
Keyword(s):  
Self Assembly ◽  
Targeted Delivery ◽  
Core Shell ◽  
Complex Structures ◽  
Self Consistent Field ◽  
Poly Ethylene Oxide ◽  
Hydrophobic Solutes ◽  
Poly Ethylene ◽  
Multicompartment Micelles ◽  
Positively Charged

Hydrophobic blocks of amphiphilic block copolymers usually form glassy micellar cores with a rigid structure that limits their applications as nanocapsules for targeted delivery. We report here on the core/shell micelles with a soft core formed<br>by self-assembly of block copolymer composed of hydrophobic and polycation blocks, poly(lauryl acrylate)-block-poly(trimethylammonioethyl acrylate) (PLA-QPDMAEA), in aqueous solution. Using scattering, microscopy and spectroscopy techniques, we showed that such copolymer forms spherical and cylindrical core/shell micelles with a fluid-like PLA core and a positively charged shell, and that these micelles can encapsulate and release hydrophobic solutes. Moreover, we discovered novel vesicle-<br>like multicompartment structures containing both soft hydrophobic and interpolyelectrolyte (IPEC) layers formed by co-assembly of PLA-QPDMAEA core/shell micelles with another diblock copolymer composed of a hydrophilic block and polyanion block poly(ethylene oxide)-block-poly(methacrylic acid) (PEO-PMAA). These complex structures were characterized by small-angle neutron scattering, supported by self-consistent field modeling that confirmed the formation of vesicle-like structures with dense PEO core, IPEC inner layer, PLA soft layer, IPEC outer layer and loose PEO corona. Due to their unique tunable properties, such multicompartment micelles with fluid and IPEC layers and hydrophilic corona can be used as nanocapsules with controllable thickness of each layer, charge and stability.<br>

Enhancing the Magnetic–Luminescent Properties of Fe3O4@Y2O3:Eu3+ Core–Shell Bifunctional Particles Using Li+ Doping

2017 ◽  
Vol 70 (8) ◽  
pp. 896
Author(s):  
Hong Zhang ◽  
Le Wang ◽  
Tuo Wu ◽  
Rubiao Chen ◽  
Dong Luo ◽  
...  
Keyword(s):  
Luminescent Properties ◽  
Undoped Sample ◽  
Magnetic Characteristics ◽  
Core Shell ◽  
Comprehensive Investigation ◽  
Li Doping ◽  
Saturation Magnetisation ◽  
Luminescent Nanoparticles ◽  
Shell Particles ◽  
Microscopic Morphology

Magnetic–luminescent nanoparticles are now attracting great attention in biochemistry and biomedicine for their promising bifunctional characteristics. In this work, we propose a strategy of Li+ doping to enhance both the luminescent and magnetic properties of Fe3O4@Y2O3:Eu3+ core–shell particles. A comprehensive investigation of phase assembly, microscopic morphology, luminescence, and magnetic characteristics of the bifunctional particles was carried out. The core–shell structured particles have a spherical morphology and the agglomerated particle size is ~1 μm in diameter. Under 254 nm excitation, the co-doped sample (5 mol-% Li+) with a dominant emission peak at 612 nm, exhibits luminescence 2.35 times more intense than the undoped sample (0 mol-% Li+). Li+ doping also leads to an improved saturation magnetisation, which was 2.41 times greater than the undoped sample.

scholarly journals Reversible Multilayered Vesicle-like Structures with Fluid Hydrophobic and Interpolyelectrolyte Layers

2020 ◽  
Author(s):  
Anastasiia Murmiliuk ◽  
Sergey K. Filippov ◽  
Oleg Rud ◽  
Peter Košovan ◽  
Zdeněk Tošner ◽  
...  
Keyword(s):  
Self Assembly ◽  
Targeted Delivery ◽  
Core Shell ◽  
Complex Structures ◽  
Self Consistent Field ◽  
Poly Ethylene Oxide ◽  
Hydrophobic Solutes ◽  
Poly Ethylene ◽  
Multicompartment Micelles ◽  
Positively Charged

Hydrophobic blocks of amphiphilic block copolymers usually form glassy micellar cores with a rigid structure that limits their applications as nanocapsules for targeted delivery. We report here on the core/shell micelles with a soft core formed<br>by self-assembly of block copolymer composed of hydrophobic and polycation blocks, poly(lauryl acrylate)-block-poly(trimethylammonioethyl acrylate) (PLA-QPDMAEA), in aqueous solution. Using scattering, microscopy and spectroscopy techniques, we showed that such copolymer forms spherical and cylindrical core/shell micelles with a fluid-like PLA core and a positively charged shell, and that these micelles can encapsulate and release hydrophobic solutes. Moreover, we discovered novel vesicle-<br>like multicompartment structures containing both soft hydrophobic and interpolyelectrolyte (IPEC) layers formed by co-assembly of PLA-QPDMAEA core/shell micelles with another diblock copolymer composed of a hydrophilic block and polyanion block poly(ethylene oxide)-block-poly(methacrylic acid) (PEO-PMAA). These complex structures were characterized by small-angle neutron scattering, supported by self-consistent field modeling that confirmed the formation of vesicle-like structures with dense PEO core, IPEC inner layer, PLA soft layer, IPEC outer layer and loose PEO corona. Due to their unique tunable properties, such multicompartment micelles with fluid and IPEC layers and hydrophilic corona can be used as nanocapsules with controllable thickness of each layer, charge and stability.<br>

scholarly journals Functional Magnetic Core-Shell System-Based Iron Oxide Nanoparticle Coated with Biocompatible Copolymer for Anticancer Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 120 ◽  
Author(s):  
Thai Hoang Thi ◽  
Diem-Huong Nguyen Tran ◽  
Long Bach ◽  
Hieu Vu-Quang ◽  
Duy Nguyen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Superparamagnetic Iron Oxide ◽  
Proton Nuclear Magnetic Resonance ◽  
Iron Oxide Nanoparticle ◽  
Core Shell ◽  
Anticancer Drug Delivery ◽  
Shell System

Polymer coating has drawn increasing attention as a leading strategy to overcome the drawbacks of superparamagnetic iron oxide nanoparticles (SPIONs) in targeted delivery of anticancer drugs. In this study, SPIONs were modified with heparin-Poloxamer (HP) shell to form a SPION@HP core-shell system for anticancer drug delivery. The obtained formulation was characterized by techniques including transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), vibration sample magnetometer (VSM), proton nuclear magnetic resonance (1H-NMR), and powder X-ray diffraction (XRD). Results showed the successful attachment of HP shell on the surface of SPION core and the inability to cause considerable effects to the crystal structure and unique magnetic nature of SPION. The core-shell system maintains the morphological features of SPIONs and the desired size range. Notably, Doxorubicin (DOX), an anticancer drug, was effectively entrapped into the polymeric shell of SPION@HP, showing a loading efficiency of 66.9 ± 2.7% and controlled release up to 120 h without any initial burst effect. Additionally, MTT assay revealed that DOX-loaded SPION@HP exerted great anticancer effect against HeLa cells and could be safely used. These results pave the way for the application of SPION@HP as an effective targeted delivery system for cancer treatment.

A targeted drug delivery system based on folic acid-functionalized upconversion luminescent nanoparticles

2017 ◽  
Vol 31 (9) ◽  
pp. 1247-1256 ◽  
Author(s):  
Xuhua Liang ◽  
Jun Fan ◽  
Yanyan Zhao ◽  
Min Cheng ◽  
Xuejun Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Targeted Delivery ◽  
Cell Imaging ◽  
Ostwald Ripening ◽  
Upconversion Luminescence ◽  
Mesoporous Structure ◽  
Anticancer Drug Delivery ◽  
Free Doxorubicin ◽  
Luminescent Nanoparticles

In this paper, multifunctional upconversion luminescent NaYF4:Yb,Er nanoparticles with excellent hollow mesoporous structure were first fabricated. The effects of various reaction conditions on the morphology and size of the as-prepared samples were investigated in detail and Ostwald ripening effect was adapted to explain the formation mechanism of the HMUCNPs. Then, folic acid, a well-known ligand for the selective targeting of drugs into tumor cells, was conjugated to the surface of the hollow mesoporous structured upconversion luminescent nanoparticles (HMUCNPs) via amide reaction for targeted delivery of anticancer drugs so as to enhance the therapeutic efficacy. The properties were extensively studied, which indicated the obtained samples showed a typical hollow mesoporous structure and excellent upconversion luminescence that were useful for cell imaging and drug delivery. Drug storage/release properties were demonstrated to be pH responsive, in which the drug release might be beneficial at the reduced pH in certain cancerous tissues for targeted release and controlled therapy at the pathological sites. Meanwhile, DOX-NaYF4:Yb,Er-FA HMUCNPs exhibited greater cytotoxicity than free doxorubicin hydrochloride because folic acid-conjugated HMUCNPs can be specifically taken up by FR-positive KB cells via a receptor-mediated endocytosis. Therefore, the folic acid-functionalized nanoparticles combining upconversion luminescent property and hollow mesoporous structure have potential for simultaneous targeted anticancer drug delivery and cell imaging.

Sign in / Sign up

Export Citation Format

Share Document