scholarly journals Alteration of structural and mechanical properties of the temporomandibular joint disc following elastase digestion

2020 ◽  
Vol 108 (8) ◽  
pp. 3228-3240
Author(s):  
Sepanta Fazaeli ◽  
Fereshteh Mirahmadi ◽  
Vincent Everts ◽  
Theodoor H. Smit ◽  
Jan H. Koolstra ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Temporomandibular Joint ◽  
Temporomandibular Joint Disc

scholarly journals Tissue engineering toward temporomandibular joint disc regeneration

2018 ◽  
Vol 10 (446) ◽  
pp. eaaq1802 ◽  
Author(s):  
Natalia Vapniarsky ◽  
Le W. Huwe ◽  
Boaz Arzi ◽  
Meghan K. Houghton ◽  
Mark E. Wong ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Temporomandibular Joint ◽  
Treated Group ◽  
Defect Closure ◽  
Repair Tissue ◽  
Temporomandibular Joint Disc ◽  
Disc Regeneration ◽  
Tmj Disc ◽  
Engineering Strategy

Treatments for temporomandibular joint (TMJ) disc thinning and perforation, conditions prevalent in TMJ pathologies, are palliative but not reparative. To address this, scaffold-free tissue-engineered implants were created using allogeneic, passaged costal chondrocytes. A combination of compressive and bioactive stimulation regimens produced implants with mechanical properties akin to those of the native disc. Efficacy in repairing disc thinning was examined in minipigs. Compared to empty controls, treatment with tissue-engineered implants restored disc integrity by inducing 4.4 times more complete defect closure, formed 3.4-fold stiffer repair tissue, and promoted 3.2-fold stiffer intralaminar fusion. The osteoarthritis score (indicative of degenerative changes) of the untreated group was 3.0-fold of the implant-treated group. This tissue engineering strategy paves the way for developing tissue-engineered implants as clinical treatments for TMJ disc thinning.

Natural Course of Untreated Symptomatic Temporomandibular Joint Disc Displacement without Reduction

1998 ◽  
Vol 77 (2) ◽  
pp. 361-365 ◽  
Author(s):  
K. Kurita ◽  
P.-L. Westesson ◽  
H. Yuasa ◽  
M. Toyama ◽  
J. Machida ◽  
...  
Keyword(s):  
Temporomandibular Joint ◽  
Natural Course ◽  
Disc Displacement ◽  
Temporomandibular Joint Disc
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