Characterization of the conversion of bone cement and borate bioactive glass composites

2020 ◽  
Vol 108 (4) ◽  
pp. 1580-1591
Author(s):  
Kimberly A. Cole ◽  
Grahmm A. Funk ◽  
Mohamed N. Rahaman ◽  
Terence E. McIff
Keyword(s):  
Bioactive Glass ◽  
Bone Cement ◽  
Glass Composites ◽  
Borate Bioactive Glass

scholarly journals Antibiotic Elution and Mechanical Strength of PMMA Bone Cement Loaded With Borate Bioactive Glass

2018 ◽  
Vol 3 (4) ◽  
pp. 187-196 ◽  
Author(s):  
Grahmm A. Funk ◽  
Jonathan C. Burkes ◽  
Kimberly A. Cole ◽  
Mohamed N. Rahaman ◽  
Terence E. McIff
Keyword(s):  
Mechanical Strength ◽  
Bioactive Glass ◽  
Bone Cement ◽  
Weight Bearing ◽  
Cement Composites ◽  
Delivery Vehicle ◽  
Glass Composites ◽  
Pmma Bone Cement ◽  
Borate Bioactive Glass ◽  
Do So

Abstract. Introduction: Local delivery of antibiotics using bone cement as the delivery vehicle is an established method of managing implant-associated orthopedic infections. Various fillers have been added to cement to increase antibiotic elution, but they often do so at the expense of strength. This study evaluated the effect of adding a borate bioactive glass, previously shown to promote bone formation, on vancomycin elution from PMMA bone cement.Methods: Five cement composites were made: three loaded with borate bioactive glass along with 0, 1, and 5 grams of vancomycin and two without any glass but with 1 and 5 grams vancomycin to serve as controls. The specimens were soaked in PBS. Eluate of vancomycin was collected every 24 hours and analyzed by HPLC. Orthopedic-relevant mechanical properties of each composite were tested over time.Results: The addition of borate bioactive glass provided an increase in vancomycin release at Day 1 and an increase in sustained vancomycin release throughout the treatment period. An 87.6% and 21.1% increase in cumulative vancomycin release was seen for both 1g and 5g loading groups, respectively. Compressive strength of all composites remained above the weight-bearing threshold of 70 MPa throughout the duration of the study with the glass-containing composites showing comparable strength to their respective controls.Conclusion: The incorporation of borate bioactive glass into commercial PMMA bone cement can significantly increase the elution of vancomycin. The mechanical strength of the cement-glass composites remained above 70 MPa even after soaking for 8 weeks, suggesting their suitability for orthopedic weight-bearing applications.

Characterization of carbon nanotube (MWCNT) containing P(3HB)/bioactive glass composites for tissue engineering applications

2010 ◽  
Vol 6 (3) ◽  
pp. 735-742 ◽  
Author(s):  
Superb K. Misra ◽  
F. Ohashi ◽  
Sabeel P. Valappil ◽  
Jonathan C. Knowles ◽  
I. Roy ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Carbon Nanotube ◽  
Bioactive Glass ◽  
Engineering Applications ◽  
Glass Composites

scholarly journals Enhanced osteointegration of poly(methylmethacrylate) bone cements by incorporating strontium-containing borate bioactive glass

2017 ◽  
Vol 14 (131) ◽  
pp. 20161057 ◽  
Author(s):  
Xu Cui ◽  
Chengcheng Huang ◽  
Meng Zhang ◽  
Changshun Ruan ◽  
Songlin Peng ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Cement ◽  
Setting Time ◽  
Composite Cement ◽  
Collagen Secretion ◽  
Pmma Bone Cement ◽  
Borate Bioactive Glass ◽  
Composite Cements ◽  
Pmma Cement

Although poly(methylmethacrylate) (PMMA) cements are widely used in orthopaedics, they have numerous drawbacks. This study aimed to improve their bioactivity and osseointegration by incorporating strontium-containing borate bioactive glass (SrBG) as the reinforcement phase and bioactive filler of PMMA cement. The prepared SrBG/PMMA composite cements showed significantly decreased polymerization temperature when compared with PMMA and retained properties of appropriate setting time and high mechanical strength. The bioactivity of SrBG/PMMA composite cements was confirmed in vitro , evidenced by ion release (Ca, P, B and Sr) from SrBG particles. The cellular responses of MC3T3-E1 cells in vitro demonstrated that SrBG incorporation could promote adhesion, migration, proliferation and collagen secretion of cells. Furthermore, our in vivo investigation revealed that SrBG/PMMA composite cements presented better osseointegration than PMMA bone cement. SrBG in the composite cement could stimulate new-bone formation around the interface between the composite cement and host bone at eight and 12 weeks post-implantation, whereas PMMA bone cement only stimulated development of an intervening connective tissue layer. Consequently, the SrBG/PMMA composite cement may be a better alternative to PMMA cement in clinical applications and has promising orthopaedic applications by minimal invasive surgery.

Synthesis and characterization of electrospun bioactive glass nanofibers-reinforced calcium sulfate bone cement and its cell biological response

2020 ◽  
Vol 46 (8) ◽  
pp. 10029-10039 ◽  
Author(s):  
Mehdi Shams ◽  
Nader Nezafati ◽  
Delaram Poormoghadam ◽  
Siamak Zavareh ◽  
Ali Zamanian ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Cement ◽  
Calcium Sulfate ◽  
Biological Response ◽  
Synthesis And Characterization

Fabrication and characterization of poly-(ε)-caprolactone and bioactive glass composites for tissue engineering applications

2015 ◽  
Vol 49 ◽  
pp. 632-639 ◽  
Author(s):  
Ali Mohammadkhah ◽  
Laura M. Marquardt ◽  
Shelly E. Sakiyama-Elbert ◽  
Delbert E. Day ◽  
Amy B. Harkins
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Engineering Applications ◽  
Glass Composites ◽  
Fabrication And Characterization
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