scholarly journals A cell‐free approach with a supporting biomaterial in the form of dispersed microspheres induces hyaline cartilage formation in a rabbit knee model

2020 ◽  
Vol 108 (4) ◽  
pp. 1428-1438 ◽  
Author(s):  
Javier Zurriaga Carda ◽  
Maria L. Lastra ◽  
Carmen M. Antolinos‐Turpin ◽  
Rosa M. Morales‐Román ◽  
María Sancho‐Tello ◽  
...  
Keyword(s):  
Hyaline Cartilage ◽  
Cartilage Formation ◽  
Knee Model ◽  
Rabbit Knee ◽  
A Cell

scholarly journals 80 A RABBIT KNEE MODEL OF CONTROLLED INSTABILITY

2008 ◽  
Vol 16 ◽  
pp. S48-S49
Author(s):  
Y. Tochigi ◽  
T.O. McKinley ◽  
A.D. Heiner ◽  
D.C. Fredericks ◽  
J.A. Bobst ◽  
...  
Keyword(s):  
Knee Model ◽  
Rabbit Knee

scholarly journals Hyaline cartilage formation and tumorigenesis of implanted tissues derived from human induced pluripotent stem cells

2015 ◽  
Vol 36 (3) ◽  
pp. 179-186 ◽  
Author(s):  
Taku SAITO ◽  
Fumiko YANO ◽  
Daisuke MORI ◽  
Manabu KAWATA ◽  
Kazuto HOSHI ◽  
...  
Keyword(s):  
B Cells ◽  
Hyaline Cartilage ◽  
Cartilage Formation ◽  
Induced Pluripotent

scholarly journals Hyaline cartilage differentiation of fibroblasts in regeneration and regenerative medicine

Development ◽  
2022 ◽  
Author(s):  
Ling Yu ◽  
Yu-Lieh Lin ◽  
Mingquan Yan ◽  
Tao Li ◽  
Emily Y. Wu ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Regenerative Medicine ◽  
Hyaline Cartilage ◽  
Fibroblast Cell ◽  
Similar Response ◽  
Articular Chondrocyte ◽  
Joint Injury ◽  
A Cell ◽  
Culture Strategy

Amputation injuries in mammals are typically non-regenerative, however joint regeneration is stimulated by BMP9 treatment (Yu et al., 2019) indicating the presence of latent articular chondrocyte progenitor cells. BMP9 induces a battery of chondrogenic genes in vivo, and a similar response is observed in cultures of amputation wound cells. Extended cultures of BMP9 treated cells results in differentiation of hyaline cartilage and single cell RNAseq analysis identified wound fibroblasts as BMP9 responsive. This culture model was used to identify a BMP9 responsive adult fibroblast cell line and a culture strategy was developed to engineer hyaline cartilage for engraftment into an acutely damaged joint. Transplanted hyaline cartilage survived engraftment and maintained a hyaline cartilage phenotype but did not form mature articular cartilage. In addition, individual hypertrophic chondrocytes were identified in some samples indicating that the acute joint injury site can promote osteogenic progression of engrafted hyaline cartilage. The findings identify fibroblasts as a cell source for engineering articular cartilage and establishes a novel experimental strategy that bridges the gap between regeneration biology and regenerative medicine.

scholarly journals Intraarticular injection of allogenic chondroprogenitors for treatment of osteoarthritis in rabbit knee model

2019 ◽  
Vol 10 (1) ◽  
pp. 16-23 ◽  
Author(s):  
Elizabeth Vinod ◽  
Jithu Varghese James ◽  
Arumugam Sabareeswaran ◽  
Soosai Manickam Amirtham ◽  
George Thomas ◽  
...  
Keyword(s):  
Intraarticular Injection ◽  
Knee Model ◽  
Rabbit Knee

Treatment of articular defects with meniscal allografts in a rabbit knee model

1995 ◽  
Vol 11 (2) ◽  
pp. 185-193 ◽  
Author(s):  
Yoshio Sumen ◽  
Mitsuo Ochi ◽  
Yoshikazu Ikuta
Keyword(s):  
Knee Model ◽  
Rabbit Knee

Experimental Replacement of the Surface Defect of Rat Hyaline Cartilage by a Cell-Engineered Construct

2021 ◽  
Author(s):  
M. S. Bozhokin ◽  
S. A. Bozhkova ◽  
G. I. Netylko ◽  
D. G. Nakonechny ◽  
Y. A. Nashchekina ◽  
...  
Keyword(s):  
Surface Defect ◽  
Hyaline Cartilage ◽  
A Cell ◽  
Experimental Replacement

New rabbit knee model of posttraumatic joint contracture: Indirect capsular damage induces a severe contracture

2009 ◽  
Vol 27 (8) ◽  
pp. 1028-1032 ◽  
Author(s):  
Sergiy Nesterenko ◽  
Mark E. Morrey ◽  
Matthew P. Abdel ◽  
Kai-Nan An ◽  
Scott P. Steinmann ◽  
...  
Keyword(s):  
Joint Contracture ◽  
Knee Model ◽  
Rabbit Knee
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