A biphasic calcium phosphate ceramic scaffold loaded with oxidized cellulose nanofiber–gelatin hydrogel with immobilized simvastatin drug for osteogenic differentiation

2020 ◽  
Vol 108 (4) ◽  
pp. 1229-1238 ◽  
Author(s):  
Omar Faruq ◽  
Shithima Sayed ◽  
Boram Kim ◽  
Soo‐Bin Im ◽  
Byong‐Taek Lee
Keyword(s):  
Calcium Phosphate ◽  
Osteogenic Differentiation ◽  
Biphasic Calcium Phosphate ◽  
Cellulose Nanofiber ◽  
Oxidized Cellulose ◽  
Calcium Phosphate Ceramic ◽  
Ceramic Scaffold ◽  
Gelatin Hydrogel

Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair

2007 ◽  
Vol 361-363 ◽  
pp. 119-122 ◽  
Author(s):  
J.H. Lim ◽  
J.H. Park ◽  
Eui Kyun Park ◽  
Hae Jung Kim ◽  
Il Kyu Park ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Bone Defects ◽  
Calcium Phosphate Ceramic ◽  
Ceramic Scaffold ◽  
Porous Biphasic Calcium Phosphate

An appropriate scaffold, which provides structural support for transplanted cells and acts as a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. We developed a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold by adopting a foaming method, and evaluated its efficiency as a bone substitute and a scaffold for bone tissue engineering by in vitro and in vivo biocompatible analysis and its osteogenic healing capacity in rat tibial bone defects. They have spherical pores averaging 400um in diameter and interconnecting interpores averaging 70um in diameter with average 85% porosity. They elicited no cytotoxicity and noxious effect on cellular proliferation and osteoblastic differentiation during the cell-scaffold construct formation. Also the bone defects grafted with fully interconnected globular porous biphasic calcium phosphate ceramic blocks revealed excellent bone healing within 3 weeks. These findings suggest that the fully interconnected porous biphasic calcium phosphate scaffold formed by the foaming method can be a promising bone substitute and a scaffold for bone tissue engineering.

Comparison of Osteoinduction by Autologous Bone and Biphasic Calcium Phosphate Ceramic in Goats

2007 ◽  
pp. 1063-1066
Author(s):  
Borhane H. Fellah ◽  
Olivier Gauthier ◽  
Pierre Weiss ◽  
Daniel Chappard ◽  
Pierre Layrolle
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Calcium Phosphate Ceramic ◽  
Autologous Bone

scholarly journals Bone Loss around Dental Implants 5 Years after Implantation of Biphasic Calcium Phosphate (HAp/βTCP) Granules

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Vadims Klimecs ◽  
Alexanders Grishulonoks ◽  
Ilze Salma ◽  
Laura Neimane ◽  
Janis Locs ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Calcium Phosphate ◽  
Bone Loss ◽  
Dental Implants ◽  
Biphasic Calcium Phosphate ◽  
Alveolar Bone ◽  
Clinical Situation ◽  
Cone Beam ◽  
Calcium Phosphate Ceramic ◽  
Middle Point

Biphasic calcium phosphate ceramic granules (0.5–1.0 mm) with a hydroxyapatite and β-tricalcium phosphate ratio of 90/10 were used. Biphasic calcium phosphate ceramic granules produced in the Riga Technical University, Riga Rudolph Cimdins Biomaterials Innovation and Development Centre, were used for filling the bone loss on 18 patients with peri-implantitis. After 5 years at the minimum, clinical and 3D cone-beam computed tomography control was done. Clinical situation confirmed good stability of implants without any signs of inflammation around. Radiodensity of the previous gap and alveolar bone horizontally from middle point of dental implants showed similar radiodensity as in normal alveolar bone. This trial is registered with ISRCTN13514478.

Macro/Microporous Biphasic Calcium Phosphate Cylinders and Resorbable Collagen Membranes for Guided Bone Growth

2007 ◽  
Vol 361-363 ◽  
pp. 439-442
Author(s):  
Borhane H. Fellah ◽  
Said Kimakhe ◽  
G. Daculsi ◽  
Pierre Layrolle
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Growth ◽  
Bone Ingrowth ◽  
Collagen Membrane ◽  
Calcium Phosphate Ceramic ◽  
Collagen Membranes ◽  
Large Bone ◽  
Empty Control ◽  
Large Bone Defects

This study aims at evaluating bone growth in critical-sized femoral defects of rats filled with macro micro porous biphasic calcium phosphate ceramic (MBCP) cylinders surrounded or not by a resorbable collagen membrane. Femoral defects left empty (control) exhibited partial bone ingrowths after 3 and 6 weeks and were completely healed at 12 weeks. The defects filled with the collagen membranes appeared partially healed suggesting that the membranes constraint bone ingrowth. Bone formation occurred around the collagen membrane which partially degraded over time. In the MBCP/membrane group, bone has grown inside the macro pores of the MBCP cylinders. Bone ingrowth was more rapid and abundant in the defects filled with MBCP alone. The combination MBCP/collagen membrane may be beneficial for the reconstruction of large bone defects without using repetitive surgeries and autologous bone grafting.

Calcium Phosphate Ceramic Blasting on Titanium Surface Improve Bone Ingrowth

2007 ◽  
Vol 361-363 ◽  
pp. 1351-1354 ◽  
Author(s):  
Eric Goyenvalle ◽  
Eric Aguado ◽  
Ronan Cognet ◽  
Xavier Bourges ◽  
G. Daculsi
Keyword(s):  
Surface Roughness ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Titanium Surface ◽  
Bone Ingrowth ◽  
High Surface ◽  
Titanium Implants ◽  
Calcium Phosphate Ceramic ◽  
Abrasive Particles ◽  
Roughened Surface

Surface roughness modulates the osseointegration of orthopaedic and dental titanium implants. High surface roughness is currently obtained by blasting of titanium implants with silica or aluminium abrasive particles. This process includes into the surface abrasive particles and may cause the release of cytotoxic silica or aluminium ions in the peri implant tissue. To overcome this drawback, we currently develop an innovative gridblasting process using Biphasic Calcium Phosphate (BCP) particles (RBBM Resorbable and Biocompatible Blast Media) to generate biocompatible roughened titanium surface. This work present the technique of blasting using RBBM particles to provide a roughened surface which does not release cytotoxic elements and (ii) to assess the effects of such a roughened surface for bone osteointegration in critical size rabbit defect. Our results demonstrate that resorbable biphasic calcium phosphate abrasive particles can be used to create titanium surface roughness. This grid blasting process increases surface roughness of titanium implants and offers a non cytotoxic surface for rapid and efficient osteointegration.

Comparison of Osteoinduction by Autologous Bone and Biphasic Calcium Phosphate Ceramic in Goats

2007 ◽  
Vol 330-332 ◽  
pp. 1063-1066 ◽  
Author(s):  
Borhane H. Fellah ◽  
Olivier Gauthier ◽  
Pierre Weiss ◽  
Daniel Chappard ◽  
Pierre Layrolle
Keyword(s):  
Calcium Phosphate ◽  
Low Temperature ◽  
Bone Tissue ◽  
Orthopedic Surgery ◽  
Biphasic Calcium Phosphate ◽  
Porous Ceramics ◽  
Calcium Phosphate Ceramic ◽  
Autologous Bone ◽  
Osteoinductive Property

Autologous bone chips are widely used in orthopedic surgery to fill large defects due to osteoinductive property but are limited in quantity. Several groups have reported the formation of mineralized bone after implantation of bioceramics in ectopic sites of different animals. However, osteoinduction by bioceramics has not yet proved to be equivalent to those of autologous bone. In this study, we compare the bone inducing capability of autologous bone chips and synthetic biphasic calcium phosphate (BCP) ceramics granules sintered at various temperatures. Both materials were implanted in muscles and femurs of goats inside hollow containers for 6, 12 and 24 weeks and analyzed by histology. This study showed that bone tissue formed in contact with micro porous ceramics sintered at low temperature as well as autologous bone chips both in ectopic and intrafemoral sites of goats.

Sign in / Sign up

Export Citation Format

Share Document