First clinical application of octacalcium phosphate collagen composite on bone regeneration in maxillary sinus floor augmentation: A prospective, single‐arm, open‐label clinical trial

2019 ◽  
Vol 108 (1) ◽  
pp. 243-252 ◽  
Author(s):  
Kei‐ichiro Miura ◽  
Yoshinori Sumita ◽  
Fumihiko Kajii ◽  
Hidenori Tanaka ◽  
Shinji Kamakura ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Bone Regeneration ◽  
Maxillary Sinus ◽  
Clinical Application ◽  
Octacalcium Phosphate ◽  
Open Label ◽  
Sinus Floor Augmentation ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
Maxillary Sinus Floor Augmentation

scholarly journals Clinical Safety Assessment of Autologous Freeze-Drying Platelet-Rich Plasma for Bone Regeneration in Maxillary Sinus Floor Augmentation: A Pilot Study

2021 ◽  
Vol 10 (8) ◽  
pp. 1678
Author(s):  
Takamitsu Koga ◽  
Yuya Nakatani ◽  
Seigo Ohba ◽  
Masahito Hara ◽  
Yoshinori Sumita ◽  
...  
Keyword(s):  
Clinical Study ◽  
Pilot Study ◽  
Bone Regeneration ◽  
Maxillary Sinus ◽  
Freeze Drying ◽  
Platelet Rich Plasma ◽  
Sinus Floor Augmentation ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
Maxillary Sinus Floor Augmentation

The purpose of this clinical study is to evaluate the safety and preliminary efficacy of autologous freeze-drying platelet-rich plasma (FD-PRP) on bone regeneration in maxillary sinus floor augmentation as a preliminary pilot study. Five patients that required sinus floor augmentation to facilitate the placement of dental implants participated in this clinical study. The PRP was prepared from the autologous peripheral blood and was lyophilized and stored at −20 °C for 4 weeks before surgery. At surgery, triple-concentrated FD-PRP (x3FD-PRP) mixed with synthetic bone grafting materials was rehydrated following the transplantation into the sinus floor. The primary outcome was a safety verification of x3FD-PRP, evaluated in terms of the clinical course and consecutive blood tests. The secondary outcome was clinical efficacy focused on bone regeneration in sinus floor augmentation evaluated by radiographic examination and implant stability. There were no adverse events, such as systemic complications, excessive inflammatory reactions, severe infection, or local site healing complications, besides those on the usual course associated with surgery. Vertical augmented height was maintained, and the initial stability of implants was achieved post-operatively in 6 months. The results obtained in this study suggest that x3FD-PRP can be used safely for bone engineering in clinical practice. Further studies are required to draw a conclusion concerning the efficacy of x3FD-PRP since this was a pilot study with a single arm and a small sample size.

scholarly journals Late recovery from foreign body sinusitis after maxillary sinus floor augmentation

2012 ◽  
Vol 2012 (dec11 1) ◽  
pp. bcr2012007434-bcr2012007434 ◽  
Author(s):  
G. Felisati ◽  
A. M. Saibene ◽  
R. Lenzi ◽  
C. Pipolo
Keyword(s):  
Foreign Body ◽  
Maxillary Sinus ◽  
Sinus Floor Augmentation ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
Late Recovery ◽  
Maxillary Sinus Floor Augmentation

scholarly journals PRF-Solution in Large Sinus Membrane Perforation with Simultaneous Implant Placement-Micro CT and Histological Analysis

Membranes ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 438
Author(s):  
Horia Mihail Barbu ◽  
Stefania Andrada Iancu ◽  
Violeta Hancu ◽  
Daniel Referendaru ◽  
Joseph Nissan ◽  
...  
Keyword(s):  
Maxillary Sinus ◽  
Micro Ct ◽  
Implant Placement ◽  
Membrane Perforation ◽  
Sinus Floor Augmentation ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
The Mean ◽  
Maxillary Sinus Floor Augmentation ◽  
Sinus Membrane

Background: The purpose of the study was to analyze the efficacy of platelet-rich fibrin (PRF) as a single augmentation material for complicated cases of maxillary sinus floor elevation, resulting from membrane perforation or previous infections. Methods: Implant insertion in the posterior region of the maxilla was simultaneously performed with maxillary sinus floor augmentation. Schneiderian membrane elevation can be accompanied by extremely serious sinus membrane perforation, due to accidental tearing or intended incision for mucocele removal. PRFs were placed in the sinus cavity both for membrane sealing and sinus floor grafting. Radiological, histological and micro-CT analyses were performed. Implant survival was assessed every 6 months for 1 to 4 years, with a mean follow up of 1.8 years, after prosthetic loading. Radiological examinations were performed on CBCT at 9 and 12 and 36 months postoperatively and revealed improved degrees of radiopacity. Results: 19 implants were simultaneously placed in the course of nine maxillary sinus floor augmentation surgeries, with successful outcomes in terms of bone grafting and implant integration. New bone formation was evidenced 12 months postoperatively on radiological examination, micro-CT analysis, and histological analysis of a harvested bone segment from the augmented maxillary sinus. The mean gain in bone height of the sinus floor augmentation was 6.43 mm, with a maximum of 9 mm. The mean amount of vital bone obtained from histologic assessment was 52.30%, while bone volume/tissue volume ratio in micro-CT 3D had a mean of 50.32%. Conclusions: PRF may be considered as an alternative treatment for a single surgery of sinus augmentation with simultaneous implant placement, even in complicated cases with significant sinus membrane tearing.

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