In vivo evaluation of an elastomeric small‐diameter vascular graft reinforced with a highly flexible Nitinol mesh

2018 ◽  
Vol 107 (4) ◽  
pp. 951-964 ◽  
Author(s):  
Giorgio Soldani ◽  
Michele Murzi ◽  
Francesco Faita ◽  
Nicole Di Lascio ◽  
Tamer Al Kayal ◽  
...  
Keyword(s):  
Vascular Graft ◽  
Small Diameter ◽  
In Vivo Evaluation

BIOSPUN VASCULAR GRAFTS: IN VIVO EVALUATION OF A NOVEL SMALL‐DIAMETER BIOACTIVE NANOFIBROUS VASCULAR GRAFT FOR ARTERIAL RECONSTRUCTION

2008 ◽  
Vol 22 (S2) ◽  
pp. 605-605
Author(s):  
Mauricio Antonio Contreras ◽  
Mathew Douglas Phaneuf ◽  
Shengqian Wu ◽  
Martin J. Bide ◽  
Frank W. LoGerfo
Keyword(s):  
Vascular Graft ◽  
Vascular Grafts ◽  
Small Diameter ◽  
Arterial Reconstruction ◽  
In Vivo Evaluation

Chitosan-based hydrogels for developing a small-diameter vascular graft: in vitro and in vivo evaluation

2017 ◽  
Vol 12 (6) ◽  
pp. 065003 ◽  
Author(s):  
A Aussel ◽  
N B Thébaud ◽  
X Bérard ◽  
V Brizzi ◽  
S Delmond ◽  
...  
Keyword(s):  
Vascular Graft ◽  
Small Diameter ◽  
In Vivo Evaluation

scholarly journals Decellularised Human Umbilical Artery as a Vascular Graft Elicits Minimal Pro-Inflammatory Host Response Ex Vivo and In Vivo

2021 ◽  
Vol 22 (15) ◽  
pp. 7981
Author(s):  
Alexander Høgsted Ahlmann ◽  
Shu Fang ◽  
Sussi Bagge Mortensen ◽  
Line Weis Andersen ◽  
Pernille Gejl Pedersen ◽  
...  
Keyword(s):  
Vascular Graft ◽  
Umbilical Artery ◽  
Ex Vivo ◽  
White Blood Cells ◽  
Small Diameter ◽  
M1 Macrophages ◽  
Host Immune Responses ◽  
Cytokine Levels ◽  
Anti Inflammatory Cytokine

Small diameter (<6 mm) vessel grafts still pose a challenge for scientists worldwide. Decellularised umbilical artery (dUA) remains promising as small diameter tissue engineered vascular graft (TEVG), yet their immunogenicity remains unknown. Herein, we evaluated the host immune responses, with a focus on the innate part, towards human dUA implantation in mice, and confirmed our findings in an ex vivo allogeneic human setup. Overall, we did not observe any differences in the number of circulating white blood cells nor the number of monocytes among three groups of mice (1) dUA patch; (2) Sham; and (3) Mock throughout the study (day −7 to 28). Likewise, we found no difference in systemic inflammatory and anti-inflammatory cytokine levels between groups. However, a massive local remodelling response with M2 macrophages were observed in the dUA at day 28, whereas M1 macrophages were less frequent. Moreover, human monocytes from allogeneic individuals were differentiated into macrophages and exposed to lyophilised dUA to maximize an eventual M1 response. Yet, dUA did not elicit any immediate M1 response as determined by the absence of CCR7 and CXCL10. Together this suggests that human dUA elicits a minimal pro-inflammatory response further supporting its use as a TEVG in an allogeneic setup.

scholarly journals The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Ruiming Liu ◽  
Yuansen Qin ◽  
Huijin Wang ◽  
Yong Zhao ◽  
Zuojun Hu ◽  
...  
Keyword(s):  
Vascular Graft ◽  
Blood Compatibility ◽  
Small Diameter

Tissue Engineered Small-Diameter Arterial Graft: In Vivo Evaluation of an Electrospun Nanofiber Scaffold

2013 ◽  
Vol 179 (2) ◽  
pp. 203
Author(s):  
K.A. Rocco ◽  
M.W. Maxfield ◽  
P.S. Bagi ◽  
H. Kurobe ◽  
T. Yi ◽  
...  
Keyword(s):  
Small Diameter ◽  
Arterial Graft ◽  
Electrospun Nanofiber ◽  
In Vivo Evaluation ◽  
Nanofiber Scaffold

A novel small-diameter vascular graft: In vivo behavior of biodegradable three-layered tubular scaffolds

2008 ◽  
Vol 99 (4) ◽  
pp. 1007-1015 ◽  
Author(s):  
Liang Zhang ◽  
Jianye Zhou ◽  
Qingping Lu ◽  
Yingjie Wei ◽  
Shengshou Hu
Keyword(s):  
Vascular Graft ◽  
Small Diameter

scholarly journals Development and in Vivo Evaluation of a Biodegradable Vascular Graft Reinforced with a Fused PCL Filament

2020 ◽  
Vol 1611 ◽  
pp. 012053
Author(s):  
E O Krivkina ◽  
K Y Klyshnikov ◽  
M A Rezvova ◽  
V V Sevostyanova ◽  
V O Tkachenko ◽  
...  
Keyword(s):  
Vascular Graft ◽  
In Vivo Evaluation

The Use of Antithrombotic Therapies in Reducing Synthetic Small-Diameter Vascular Graft Thrombosis

2012 ◽  
Vol 46 (3) ◽  
pp. 212-222 ◽  
Author(s):  
Mark Tatterton ◽  
Stacy-Paul Wilshaw ◽  
Eileen Ingham ◽  
Shervanthi Homer-Vanniasinkam
Keyword(s):  
Vascular Graft ◽  
Animal Experiments ◽  
Small Diameter ◽  
In Vitro Models ◽  
In Vivo Studies ◽  
Synthetic Graft ◽  
Graft Thrombosis ◽  
Medline Search

Background. Thrombosis of synthetic small-diameter bypass grafts remains a major problem. The aim of this article is to review the antithrombotic strategies that have been used in an attempt to reduce graft thrombogenicity. Methods. A PubMed/MEDLINE search was performed using the search terms “vascular graft thrombosis,” “small-diameter graft thrombosis,” “synthetic graft thrombosis” combined with “antithrombotic,” “antiplatelet,” “anticoagulant,” “Dacron,” “PTFE,” and “polyurethane.” Results. The majority of studies on antithrombotic therapies have used either in vitro models or in vivo animal experiments. Many of the therapies used in these settings do show antithrombotic efficacy against synthetic graft materials. There is however, a distinct lack of human in vivo studies to further delineate the performance and limitations of therapies displaying good antithrombotic characteristics. Conclusion. Very few antithrombotic therapies have translated into clinical use. More human in vivo studies are required to assess the efficacy and safety of such therapies.

Sign in / Sign up

Export Citation Format

Share Document