Development of mesoporous bioactive glass nanoparticles and its use in bone tissue engineering

2018 ◽  
Vol 106 (8) ◽  
pp. 2878-2887 ◽  
Author(s):  
Chee Hoe Kong ◽  
Chris Steffi ◽  
Zhilong Shi ◽  
Wilson Wang
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Mesoporous Bioactive Glass

Preparation and Characterization of Biomimetic Mesoporous Bioactive Glass-Silk Fibroin Composite Scaffold for Bone Tissue Engineering

2013 ◽  
Vol 796 ◽  
pp. 9-14 ◽  
Author(s):  
Cai Hong Lei ◽  
Xin Xing Feng ◽  
Ya Yang Xu ◽  
Yue Rong Li ◽  
Hai Lin Zhu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Composite Scaffold ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Composite Scaffolds ◽  
Mesoporous Bioactive Glass

Three-dimensional (3D) mesoporous bioactive glass (MBG) scaffolds were obtained by using the demineralized bone matrix (DBM) and P123 as co-templates through a dip-coating method followed by evaporation induced self-assembly (EISA) process. 3D mesoporous bioactive glass-silk fibroin (MBG/SF) composite scaffolds were prepared by immersing MBG scaffolds into SF solutions with different concentration. Transmission electron microscopy (TEM), field mission scanning electron microscope (FESEM), fourier transform infrared spectroscopy (FT-IR) and wide angle X-ray diffraction (WA-XRD) were used to analyze the inner pore structures, pore sizes, morphologies and composition of the scaffolds. The in vitro bioactivity of the scaffolds was evaluated by soaking in simulated body fluid (SBF). The results showed that the MBG and MBG/SF composite scaffolds with the interconnected macroporous network and mesoporous walls could be obtained by this method. In addition, both the MBG scaffolds and the MBG/SF composite scaffolds have excellent apatite-forming bioactivity. Therefore, this method provides a simple way to prepare scaffolds for bone tissue engineering.

scholarly journals Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering

Biomaterials ◽  
2012 ◽  
Vol 33 (7) ◽  
pp. 2076-2085 ◽  
Author(s):  
Chengtie Wu ◽  
Yinghong Zhou ◽  
Wei Fan ◽  
Pingping Han ◽  
Jiang Chang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Ion Release ◽  
Cobalt Ion ◽  
Mesoporous Bioactive Glass

3D printing mesoporous bioactive glass/sodium alginate/gelatin sustained release scaffolds for bone repair

2018 ◽  
Vol 33 (6) ◽  
pp. 755-765 ◽  
Author(s):  
Jingwen Wu ◽  
Guohou Miao ◽  
Zhichao Zheng ◽  
Zhengmao Li ◽  
Wen Ren ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Sustained Release ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Sodium Alginate ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Mesoporous Bioactive Glass

Drug delivery and release are a major challenge fabricating bone tissue engineering. In this study, we fabricated new sustained release hydrogel scaffolds composited of mesoporous bioactive glass, sodium alginate and gelatin by a three-dimensional printing technique. Naringin and calcitonin gene-related peptide were used as drugs to prepare drug-loaded scaffolds by direct printing or surface absorption. The physicochemical properties of the scaffolds and the drug release profiles of the two drug-loading models were investigated. We also examined the biocompatibility of the scaffolds, as well as the effect of the released medium on the proliferation and osteogenic differentiation of human osteoblast-like MG-63 cell. The results showed that the scaffolds had a high porosity (approximately 80%) with an interconnected cubic pore structure, rough surface morphology, bioactivity and strong biocompatibility. Furthermore, the naringin or calcitonin gene-related peptide co-printed into the scaffold displayed a steady sustained release behaviour for up to 21 days without an initial burst release, while both naringin and calcitonin gene-related peptide absorbed onto the surface of the scaffold were completely released within two days. MG-63 cells cultured with the extraction containing released drugs displayed promoted cell proliferation and the expression of osteogenesis-related genes more effectively compared with the drug-free extractions. Therefore, these results demonstrate that the developed mesoporous bioactive glass/sodium alginate/gelatin sustained release scaffolds provide a potential application for bone tissue engineering.

Simvastatin-loaded nanotubular mesoporous bioactive glass scaffolds for bone tissue engineering

2019 ◽  
Vol 288 ◽  
pp. 109570 ◽  
Author(s):  
Jian Xiao ◽  
Yizao Wan ◽  
Zhiwei Yang ◽  
Yuan Huang ◽  
Yong Zhu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Mesoporous Bioactive Glass

scholarly journals Fabrication and Characterization of Cinnamaldehyde-Loaded Mesoporous Bioactive Glass Nanoparticles/PHBV-Based Microspheres for Preventing Bacterial Infection and Promoting Bone Tissue Regeneration

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1794
Author(s):  
Kittipat Chotchindakun ◽  
Jeeraporn Pekkoh ◽  
Jetsada Ruangsuriya ◽  
Kai Zheng ◽  
Irem Unalan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Antibacterial Activity ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Average Particle Size ◽  
Average Particle ◽  
Osteosarcoma Cell ◽  
Composite Microspheres ◽  
Mesoporous Bioactive Glass

Polyhydroxybutyrate-co-hydroxyvalerate (PHBV) is considered a suitable polymer for drug delivery systems and bone tissue engineering due to its biocompatibility and biodegradability. However, the lack of bioactivity and antibacterial activity hinders its biomedical applications. In this study, mesoporous bioactive glass nanoparticles (MBGN) were incorporated into PHBV to enhance its bioactivity, while cinnamaldehyde (CIN) was loaded in MBGN to introduce antimicrobial activity. The blank (PHBV/MBGN) and the CIN-loaded microspheres (PHBV/MBGN/CIN5, PHBV/MBGN/CIN10, and PHBV/MBGN/CIN20) were fabricated by emulsion solvent extraction/evaporation method. The average particle size and zeta potential of all samples were investigated, as well as the morphology of all samples evaluated by scanning electron microscopy. PHBV/MBGN/CIN5, PHBV/MBGN/CIN10, and PHBV/MBGN/CIN20 significantly exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli in the first 3 h, while CIN releasing behavior was observed up to 7 d. Human osteosarcoma cell (MG-63) proliferation and attachment were noticed after 24 h cell culture, demonstrating no adverse effects due to the presence of microspheres. Additionally, the rapid formation of hydroxyapatite on the composite microspheres after immersion in simulated body fluid (SBF) during 7 d revealed the bioactivity of the composite microspheres. Our findings indicate that this system represents an alternative model for an antibacterial biomaterial for potential applications in bone tissue engineering.

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