scholarly journals The effect of increased microporosity on bone formation within silicate-substituted scaffolds in an ovine posterolateral spinal fusion model

2016 ◽  
Vol 105 (4) ◽  
pp. 805-814 ◽  
Author(s):  
Melanie Jean Coathup ◽  
Gordon William Blunn ◽  
Charlie Campion ◽  
Chih-Yuan Ho ◽  
Karin Angela Hing
Keyword(s):  
Bone Formation ◽  
Spinal Fusion ◽  
Fusion Model ◽  
Posterolateral Spinal Fusion

scholarly journals Erythropoietin augments bone formation in a rabbit posterolateral spinal fusion model

2011 ◽  
Vol 30 (7) ◽  
pp. 1083-1088 ◽  
Author(s):  
Jan Hendrik Duedal Rölfing ◽  
Michael Bendtsen ◽  
Jonas Jensen ◽  
Maik Stiehler ◽  
Casper Bindzus Foldager ◽  
...  
Keyword(s):  
Bone Formation ◽  
Spinal Fusion ◽  
Fusion Model ◽  
Posterolateral Spinal Fusion

scholarly journals Effect of a single dose of pamidronate administered at the time of surgery in a rabbit posterolateral spinal fusion model

2010 ◽  
Vol 19 (6) ◽  
pp. 940-944 ◽  
Author(s):  
Julio Urrutia ◽  
Jorge Briceno ◽  
Maximiliano Carmona ◽  
Fernando Olavarria ◽  
Felipe Hodgson
Keyword(s):  
Single Dose ◽  
Spinal Fusion ◽  
Fusion Model ◽  
Time Of Surgery ◽  
Posterolateral Spinal Fusion

Resorbable posterolateral graft containment in a rabbit spinal fusion model

2002 ◽  
Vol 97 (4) ◽  
pp. 460-463 ◽  
Author(s):  
Ashley R. Poynton ◽  
Fengyu Zheng ◽  
Emre Tomin ◽  
Joseph M. Lane ◽  
G. Bryan Cornwall
Keyword(s):  
Spinal Fusion ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Autologous Bone Graft ◽  
Fusion Model ◽  
Content Type ◽  
Lumbar Spinal ◽  
Posterolateral Spinal Fusion ◽  
Mass Volume ◽  
Fine Print

Object. The authors studied the effect of a resorbable graft containment device in a rabbit posterolateral lumbar spinal fusion model. Methods. Twenty rabbits were divided into four groups: autologous bone graft (ABG), ABG with the MacroPore containment device (ABG + MP), demineralized bone matrix (DBM), and DBM with the containment device (DBM + MP). Fusion mass was assessed at 6 weeks with high-resolution radiography and volumetric computerized tomography. The graft containment device was associated with alteration of the fusion mass structure and significant enhancement of fusion mass volume (ABG versus ABG + MP, p = 0.027; DBM versus DBM + MP, p = 0.043). Conclusions. A bioabsorbable protective graft containment device successfully enhanced posterolateral spinal fusion mass volume.

Preparation of Hydroxyapatite/Silk Fibroin Composite and Its Adoption in Posterolateral Spinal Fusion of Rats

2020 ◽  
Vol 12 (9) ◽  
pp. 1352-1360
Author(s):  
Yu Yang ◽  
Changgui Tong ◽  
Xuegang Liang ◽  
Huanwen Zou ◽  
Kai Guan
Keyword(s):  
Spinal Fusion ◽  
Silk Fibroin ◽  
Network Structure ◽  
Apatite Crystal ◽  
Control Group ◽  
Fusion Model ◽  
Good Ability ◽  
The Face ◽  
Posterolateral Spinal Fusion

Hydroxyapatite/silk fibroin (HAp/SF) composite was prepared and applied to the posterolateral spinal fusion model in rats to observe the effect of bone fusion. Method: Calcium chloride, diammonium phosphate, SF, and polyvinyl alcohol were used as raw materials, HAp/SF composites were prepared by chemical precipitation. The microstructure of the composite, crystal phase composition, and chemical structure were analyzed by the scanning electron microscope (SEM) and X-ray diffraction (XRD), and fourier transform infrared spectrometer (FTIR Spectrometer). Through the cultivation of osteoblasts MC3T3-E1 in vitro, the adhesion and proliferation (A&P) of cells on the face of materials were investigated. Thereby, the biocompatibility of the material was characterized. HAp/SF material was applied to the rat posterolateral spinal fusion model. The osteogenesis and spinal fusion were evaluated by the imaging observation, histological observation and manual palpation. The results showed that the rod-shaped HAp with uniform size and high purity was obtained, with a diameter of 20∼40 nm and a length of 200∼500 nm, similar to the apatite crystal in natural bone tissue (BT). In composite materials, a spatial network structure was formed by the interweaving of the SF fibers, and HAp was deposited on the face of the SF or in the middle of its network structure. In the obtained HAp/SF materials, the calcium ions of HAp and the carbonyl groups of SF were used to form thermally stable complexes through strong chemical bonds. Besides, SF was a template for the directional induction of HAp crystal growth, and the growth of HAp crystal along the C axis was regulated by SF. The growth direction was parallel to the long axis of SF fibers, and was consistent with the structure of apatite crystals deposited on the face of collagen fibers in natural BT. The results of cell culture in vitro showed that: after comparison with the control group (CG) with pure Hap, the adhesion ability of cells to HAp/SF material was significantly improved. The proliferation capacity of bone artificial bone (BAM) material and HAp/SF material was also significantly improved. The nuclear and skeletal staining results of MC3T3-E1 cells on the face of three groups of materials (HAp, BAM and HAp/SF) were combined, and the results also indicated that BAM and HAp/SF materials had good ability to promote cell A&P. The results of posterolateral spinal fusion in rats showed that HAp/SF materials group palpated the posterolateral spine for fusion. The formation of new BT on the posterolateral side of the spine was revealed by the Micro-computed tomography (Micro-CT) examination. In conclusion, HAp/SF composite had good osteoblastic compatibility and can achieve good spinal fusion effect.

scholarly journals Local delivery of a novel PTHrPviamesoporous bioactive glass scaffolds to improve bone regeneration in a rat posterolateral spinal fusion model

RSC Advances ◽  
2018 ◽  
Vol 8 (22) ◽  
pp. 12484-12493 ◽  
Author(s):  
Bo Liang ◽  
Jinghuan Huang ◽  
Jianguang Xu ◽  
Xiaolin Li ◽  
Jingfeng Li
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Spinal Fusion ◽  
Bone Substitutes ◽  
Bone Defects ◽  
Local Delivery ◽  
Long Bones ◽  
Fusion Model ◽  
Posterolateral Spinal Fusion

With the development of tissue engineering, bone defects, such as fractured long bones or cavitary lesions, may be efficiently repaired and reconstructed using bone substitutes.

scholarly journals Repurposing Human Osteoarthritic Cartilage as a Bone Graft Substitute in an Athymic Rat Posterolateral Spinal Fusion Model

10.14444/5092 ◽  
2018 ◽  
Vol 12 (6) ◽  
pp. 735-742 ◽  
Author(s):  
ALAN B.C. DANG ◽  
HELENA HONG ◽  
KATIE LEE ◽  
TAMMY LUAN ◽  
SANJAY REDDY ◽  
...  
Keyword(s):  
Bone Graft ◽  
Spinal Fusion ◽  
Bone Graft Substitute ◽  
Fusion Model ◽  
Osteoarthritic Cartilage ◽  
Posterolateral Spinal Fusion

scholarly journals Effect of Whitlockite as a new bone substitute for bone formation in spinal fusion and ectopic ossification animal model

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Yuan-Zhe Jin ◽  
Guang-Bin Zheng ◽  
Minjoon Cho ◽  
Jae Hyup Lee
Keyword(s):  
Bone Formation ◽  
Spinal Fusion ◽  
Tricalcium Phosphate ◽  
Transverse Process ◽  
Posterolateral Fusion ◽  
Fusion Model ◽  
Ectopic Ossification ◽  
Spinal Fusion Surgery ◽  
Sd Rat ◽  
Ectopic Bone

Abstract Background Bone substrates like hydroxyapatite and tricalcium phosphate have been widely used for promoting spinal fusion and reducing the complications caused by autograft. Whitlockite has been reported to promote better bone formation in rat calvaria models compare with them, but no study investigated its effect on spinal fusion yet. Also, the higher osteoinductivity of whitlockite raised concern of ectopic ossification, which was a complication of spinal fusion surgery that should be avoided. Methods In this study, we compared the osteoinductivity of whitlockite, hydroxyapatite, and tricalcium phosphate porous particles with SD rat spine posterolateral fusion model and investigated whether whitlockite could induce ectopic ossification with SD rat abdominal pouch model. Results The micro-CT result from the posterolateral fusion model showed whitlockite had slightly but significantly higher percent bone volume than tricalcium phosphate, though none of the materials formed successful fusion with surrounding bone tissue. The histology results showed the bone formed on the cortical surface of the transverse process but did not form a bridge between the processes. The result from the abdominal pouch model showed whitlockite did not induce ectopic bone formation. Conclusion Whitlockite had a potential of being a better bone substrate hydroxyapatite and tricalcium phosphate in spinal fusion with low risk of inducing ectopic ossification.

Effect of the type of electrical stimulation on spinal fusion in a rat posterolateral spinal fusion model

2019 ◽  
Vol 19 (6) ◽  
pp. 1106-1120 ◽  
Author(s):  
Pyung Goo Cho ◽  
Gyu Yeol Ji ◽  
Yoon Ha ◽  
Hye Yeong Lee ◽  
Dong Ah Shin
Keyword(s):  
Electrical Stimulation ◽  
Spinal Fusion ◽  
Fusion Model ◽  
Posterolateral Spinal Fusion

Induction of Bone Formation Using a Recombinant Adenoviral Vector Carrying the Human BMP-2 Gene in a Rabbit Spinal Fusion Model

Neurosurgery ◽  
1998 ◽  
Vol 43 (3) ◽  
pp. 703-703
Author(s):  
Neill M. Wright ◽  
K. Daniel Riew ◽  
Su-Li Cheng ◽  
Louis V. Avioli ◽  
Jueren Lou
Keyword(s):  
Bone Formation ◽  
Spinal Fusion ◽  
Adenoviral Vector ◽  
Fusion Model ◽  
Recombinant Adenoviral Vector

scholarly journals Effect of Hydroxyapatite porous characteristics on healing outcomes in rabbit posterolateral spinal fusion model

2007 ◽  
Vol 16 (12) ◽  
pp. 2215-2224 ◽  
Author(s):  
Makoto Motomiya ◽  
Manabu Ito ◽  
Masahiko Takahata ◽  
Ken Kadoya ◽  
Kazuharu Irie ◽  
...  
Keyword(s):  
Spinal Fusion ◽  
Fusion Model ◽  
Posterolateral Spinal Fusion
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