Nanoscale surface modification by anodic oxidation increased bone ingrowth and reduced fibrous tissue in the porous coating of titanium-alloy femoral hip arthroplasty implants

2015 ◽  
Vol 105 (2) ◽  
pp. 283-290 ◽  
Author(s):  
Deborah J. Hall ◽  
Robert M. Urban ◽  
Robin Pourzal ◽  
Thomas M. Turner ◽  
Anastasia K. Skipor ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Surface Modification ◽  
Anodic Oxidation ◽  
Hip Arthroplasty ◽  
Bone Ingrowth ◽  
Fibrous Tissue ◽  
Porous Coating

Incorporation Of Interference Fit And Cyclic Loading In Simulation Algorithm For Better Prediction Of Micromotion Of Femoral Stems

2012 ◽  
Author(s):  
Mohammed Rafiq Abdul–Kadir ◽  
Ulrich N. Hansen
Keyword(s):  
Finite Element ◽  
Cyclic Loading ◽  
Hip Arthroplasty ◽  
Bone Ingrowth ◽  
Fibrous Tissue ◽  
Interference Fit ◽  
Press Fit ◽  
Key Words Hip ◽  
Femoral Stems

Pelonggaran aseptik adalah salah satu daripada sebab utama pembedahan ulangan tulang paha. Ini berlaku disebabkan kegagalan untuk mendapatkan cengkaman pertama yang kuat. Pergerakan antara implan dengan tulang melebihi had tertentu menghalang pertumbuhan tulang dan mengakibatkan pembentukan tisu berbentuk fiber. Dalam kajian ini, satu algoritma dicadangkan untuk meramal pergerakan implan dan seterusnya ketidakstabilan implan. Dengan menggunakan beban fisiologi, pergerakan implan relatif kepada tulang dikira menggunakan algoritma. Implan yang menggunakan sistem cengkaman tekanan telah dibentuk dan beban ulangan dikenakan untuk memberi simulasi yang sebenar. Satu ujikaji ‘in–vitro’ telah dilaksanakan terhadap empat tulang paha manusia untuk mengesahkan algoritma yang dicadangkan. Keputusan ujikaji telah mengesahkan pergerakan implan yang dijangka oleh algoritma ini. Kata kunci: tulang paha, algoritma cengkaman, pengesahan ujikaji Aseptic loosening is one of the major causes for revision surgery in hip arthroplasty. This has been attributed to failure in achieving strong primary fixation. Interface micromotion beyond a certain threshold limit inhibits bone ingrowth and favours the formation of fibrous tissue. In this study, an algorithm was constructed to predict micromotion and therefore instability of femoral stems. Based on common physiological loading, micromotion is calculated throughout the bone–implant interface. Press fit stem insertion was modelled using interference fit and cyclic loading was used to better simulate actual loading configuration. An in–vitro micromotion experiment was carried out on four human cadaveric femurs to validate the micromotion algorithm. A good correlation was obtained between finite element predictions and the in–vitro micromotion experiment. Key words: hip arthroplasty, primary stability, micromotion algorithm, experimental validation, finite element

Study on High Order TiO2 Nanotube Arrays and the Mechanical Properties

2013 ◽  
Vol 842 ◽  
pp. 247-251 ◽  
Author(s):  
Dong Ping Long ◽  
Jian Rong Xue ◽  
Zhi Xin Yan
Keyword(s):  
Mechanical Properties ◽  
Titanium Alloy ◽  
Surface Modification ◽  
Anodic Oxidation ◽  
High Order ◽  
Nanotube Arrays ◽  
Micro Hardness ◽  
Paper Surface

In this paper surface modification was adopted on 3 kinds of titanium alloy and TiO2 nanotubes arrays were prepared on these surfaces by anodic oxidation method.nanoindentation and nanoscratch experiments were performed to test the mechanical properties of TiO2 film, such as micro hardness and elastic modulus.Through comparing and analyzing,it is seen that,The film generated on the TC4 has better mechanical properties than the others and TC4 is better substrate for surface modification by anodic oxidation as the implanted materials.

scholarly journals Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 724
Author(s):  
Amilton Iatecola ◽  
Guilherme Arthur Longhitano ◽  
Luiz Henrique Martinez Antunes ◽  
André Luiz Jardini ◽  
Emilio de Castro Miguel ◽  
...  
Keyword(s):  
Surface Modification ◽  
Additive Manufacturing ◽  
Bone Ingrowth ◽  
Orthopedic Implants ◽  
Coated Sample ◽  
High Mechanical Strength ◽  
Coated Surface ◽  
Surface Modification Techniques ◽  
Almost All ◽  
Cobalt Base

Cobalt-base alloys (Co-Cr-Mo) are widely employed in dentistry and orthopedic implants due to their biocompatibility, high mechanical strength and wear resistance. The osseointegration of implants can be improved by surface modification techniques. However, complex geometries obtained by additive manufacturing (AM) limits the efficiency of mechanical-based surface modification techniques. Therefore, plasma immersion ion implantation (PIII) is the best alternative, creating nanotopography even in complex structures. In the present study, we report the osseointegration results in three conditions of the additively manufactured Co-Cr-Mo alloy: (i) as-built, (ii) after PIII, and (iii) coated with titanium (Ti) followed by PIII. The metallic samples were designed with a solid half and a porous half to observe the bone ingrowth in different surfaces. Our results revealed that all conditions presented cortical bone formation. The titanium-coated sample exhibited the best biomechanical results, which was attributed to the higher bone ingrowth percentage with almost all medullary canals filled with neoformed bone and the pores of the implant filled and surrounded by bone ingrowth. It was concluded that the metal alloys produced for AM are biocompatible and stimulate bone neoformation, especially when the Co-28Cr-6Mo alloy with a Ti-coated surface, nanostructured and anodized by PIII is used, whose technology has been shown to increase the osseointegration capacity of this implant.

scholarly journals Assessment of Titanate Nanolayers in Terms of Their Physicochemical and Biological Properties

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 806
Author(s):  
Michalina Ehlert ◽  
Aleksandra Radtke ◽  
Katarzyna Roszek ◽  
Tomasz Jędrzejewski ◽  
Piotr Piszczek
Keyword(s):  
Surface Modification ◽  
Substrate Surface ◽  
Biological Properties ◽  
Structure Characterization ◽  
Porous Coating ◽  
Apatite Formation ◽  
Sem Images ◽  
Energy Dispersion Spectroscopy ◽  
X Ray

The surface modification of titanium substrates and its alloys in order to improve their osseointegration properties is one of widely studied issues related to the design and production of modern orthopedic and dental implants. In this paper, we discuss the results concerning Ti6Al4V substrate surface modification by (a) alkaline treatment with a 7 M NaOH solution, and (b) production of a porous coating (anodic oxidation with the use of potential U = 5 V) and then treating its surface in the abovementioned alkaline solution. We compared the apatite-forming ability of unmodified and surface-modified titanium alloy in simulated body fluid (SBF) for 1–4 weeks. Analysis of the X-ray diffraction patterns of synthesized coatings allowed their structure characterization before and after immersing in SBF. The obtained nanolayers were studied using Raman spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy (DRIFT), and scanning electron microscopy (SEM) images. Elemental analysis was carried out using X-ray energy dispersion spectroscopy (SEM EDX). Wettability and biointegration activity (on the basis of the degree of integration of MG-63 osteoblast-like cells, L929 fibroblasts, and adipose-derived mesenchymal stem cells cultured in vitro on the sample surface) were also evaluated. The obtained results proved that the surfaces of Ti6Al4V and Ti6Al4V covered by TiO2 nanoporous coatings, which were modified by titanate layers, promote apatite formation in the environment of body fluids and possess optimal biointegration properties for fibroblasts and osteoblasts.

Biocompatible Ceramic-Biopolymer Coatings Obtained by Electrophoretic Deposition on Electron Beam Structured Titanium Alloy Surfaces

2016 ◽  
Vol 879 ◽  
pp. 1552-1557
Author(s):  
C. Ramskogler ◽  
L. Cordero ◽  
Fernando Warchomicka ◽  
A.R. Boccaccini ◽  
Christof Sommitsch
Keyword(s):  
Titanium Alloy ◽  
Surface Modification ◽  
Electron Beam ◽  
Electrophoretic Deposition ◽  
Composite Coatings ◽  
Substrate Surface ◽  
3D Structure ◽  
Titania Nanoparticles ◽  
Structured Surfaces ◽  
Major Interest

An area of major interest in biomedical engineering is currently the development of improved materials for medical implants. Research efforts are being focused on the investigation of surface modification methods for metallic prostheses due to the fundamental bioinert character of these materials and the possible ion release from their surfaces, which could potentially induce the interfacial loosening of devices after implantation. Electron beam (EB) structuring is a novel technique to control the surface topography in metals. Electrophoretic deposition (EPD) offers the feasibility to deposit at room temperature a variety of materials on conductive substrates from colloidal suspensions under electric fields. In this work single layers of chitosan composite coatings containing titania nanoparticles (n-TiO2) were deposit by EPD on electron beam (EB) structured Ti6Al4V titanium alloy. Surface structures were designed following different criteria in order to develop specific topography on the Ti6Al4V substrate. n-TiO2 particles were used as a model particle in order to demonstrate the versatility of the proposed technique for achieving homogenous chitosan based coatings on structured surfaces. A linear relation between EPD time and deposition yield on different patterned Ti6Al4V surfaces was determined under constant voltage conditions, obtaining homogeneous EPD coatings which replicate the 3D structure (pattern) of the substrate surface. The present results show that a combination of both techniques can be considered a promising surface modification approach for metallic implants, which should lead to improved interaction between the implant surface and the biological environment for orthopaedic applications.

Bone Ingrowth Around an Uncemented Femoral Implant Using Mechanoregulatory Algorithm: A Multiscale Finite Element Analysis

2021 ◽  
Author(s):  
Basil Mathai ◽  
Sanjay Gupta
Keyword(s):  
Finite Element ◽  
Bone Tissue ◽  
Bone Ingrowth ◽  
Progressive Increase ◽  
Stair Climbing ◽  
Porous Coating ◽  
Fe Model ◽  
Implant Surface ◽  
Element Analysis ◽  
Medial Side

Abstract The primary fixation and long-term stability of a cementless femoral implant depend on bone ingrowth within the porous coating. Although attempts were made to quantify the peri-implant bone ingrowth using the finite element (FE) analysis and mechanoregulatory principles, the tissue differentiation patterns on a porous-coated hip stem have scarcely been investigated. The objective of this study is to predict the spatial distribution of evolutionary bone ingrowth around an uncemented hip stem, using a 3D multiscale mechanobiology based numerical framework. Multiple load cases representing a variety of daily living activities, including walking, stair climbing, sitting down and standing up from a chair, were used as applied loading conditions. The study accounted for the local variations in host bone material properties and implant-bone relative displacements of the macroscale implanted FE model, in order to predict bone ingrowth in microscale representative volume elements (RVEs) of twelve interfacial regions. In majority RVEs, 20-70% bone tissue (immature and mature) was predicted after two months, contributing towards a progressive increase in average Young's modulus (1200-3000 MPa) of the inter-bead tissue layer. Higher bone ingrowth (mostly greater than 60%) was predicted in the antero-lateral regions of the implant, as compared to the postero-medial side (20-50%). New bone tissue was formed deeper inside the inter-bead spacing, adhering to the implant surface. The study helps to gain an insight into the degree of osseointegration of a porous-coated femoral implant.

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