Remineralization of demineralized bone matrix in critical size cranial defects in rats: A 6-month follow-up study

2015 ◽  
Vol 104 (7) ◽  
pp. 1336-1342 ◽  
Author(s):  
Dénes B. Horváthy ◽  
Gabriella Vácz ◽  
Ildikó Toró ◽  
Tamás Szabó ◽  
Zoltán May ◽  
...  
Keyword(s):  
Critical Size ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Follow Up Study ◽  
Demineralized Bone

scholarly journals Osteoformation potential of an allogenic partially demineralized bone matrix in critical-size defects in the rat calvarium

2021 ◽  
pp. 112207
Author(s):  
Ahmad Moustapha Diallo ◽  
Solène Rota ◽  
Michel Boissière ◽  
Raphaël Bardonnet ◽  
Emmanuel Pauthe ◽  
...  
Keyword(s):  
Critical Size ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Critical Size Defects ◽  
Demineralized Bone

Comparative Assessment of Autogenous Cancellous Bone Graft and Bovine-Derived Demineralized Bone Matrix for Secondary Alveolar Bone Grafting in Patients With Unilateral Cleft Lip and Palate

2021 ◽  
pp. 105566562110251
Author(s):  
Vijay Kumar ◽  
Vidya Rattan ◽  
Sachin Rai ◽  
Satinder Pal Singh ◽  
Jai Kumar Mahajan
Keyword(s):  
Bone Graft ◽  
Iliac Crest ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Volumetric Analysis ◽  
Group I ◽  
Alveolar Bone Grafting ◽  
Group Ii ◽  
Demineralized Bone

Objective: Comparison between bovine-derived demineralized bone matrix (DMBM) and iliac crest graft over long term for secondary alveolar bone grafting (SABG) in patients with unilateral cleft lip and palate (UCLP) in terms of radiological and clinical outcomes. Design: Prospective, randomized, parallel groups, double-blind, controlled trial. Setting: Unit of Oral and Maxillofacial Surgery, Oral Health Science Centre, Postgraduate Institute of Medical Education & Research, Chandigarh. Participants: Twenty patients with UCLP. Interventions: Patients were allocated into group I (Iliac crest bone graft) and group II (DMBM) for SABG. Outcomes were assessed at 2 weeks, 6 months, and then after mean follow-up period of 63 months. Outcomes Measures: Volumetric analysis of the grafted bone in the alveolar cleft site was done through cone beam computed tomography using Cavalieri principle and modified assessment tool. Clinical assessment was performed in terms of pain, swelling, duration of hospital stay, cost of surgery, alar base symmetry, and donor site morbidity associated with iliac crest harvesting. Results: Volumetric analysis through Cavalieri principle revealed comparable bone uptake at follow-up of 6 months between group I (70%) and group II (69%). Modified assessment tool showed no significant difference between horizontal and vertical bone scores over short- and long-term follow-up. In group II, there was higher cost of surgery, but no donor site morbidity unlike group I. Conclusions: Demineralized bone matrix proved analogous to iliac crest bone graft as per volumetric analysis over shorter period. However, although statistically insignificant, net bone volume achieved was lower than the iliac crest graft at longer follow-up.

scholarly journals First Human Leucocyte Antigen (HLA) Response and Safety Evaluation of Fibrous Demineralized Bone Matrix in a Critical Size Femoral Defect Model of the Sprague-Dawley Rat

Materials ◽  
2020 ◽  
Vol 13 (14) ◽  
pp. 3120
Author(s):  
Nicolas Söhling ◽  
Maximilian Leiblein ◽  
Alexander Schaible ◽  
Maren Janko ◽  
Joachim Schwäble ◽  
...  
Keyword(s):  
Bone Healing ◽  
Critical Size ◽  
Demineralized Bone Matrix ◽  
High Surface ◽  
Bone Matrix ◽  
Volume Ratio ◽  
Bone Allograft ◽  
Control Group ◽  
Sprague Dawley ◽  
Demineralized Bone

Treatment of large bone defects is one of the great challenges in contemporary orthopedic and traumatic surgery. Grafts are necessary to support bone healing. A well-established allograft is demineralized bone matrix (DBM) prepared from donated human bone tissue. In this study, a fibrous demineralized bone matrix (f-DBM) with a high surface-to-volume ratio has been analyzed for toxicity and immunogenicity. f-DBM was transplanted to a 5-mm, plate-stabilized, femoral critical-size-bone-defect in Sprague-Dawley (SD)-rats. Healthy animals were used as controls. After two months histology, hematological analyses, immunogenicity as well as serum biochemistry were performed. Evaluation of free radical release and hematological and biochemical analyses showed no significant differences between the control group and recipients of f-DBM. Histologically, there was no evidence of damage to liver and kidney and good bone healing was observed in the f-DBM group. Reactivity against human HLA class I and class II antigens was detected with mostly low fluorescence values both in the serum of untreated and treated animals, reflecting rather a background reaction. Taken together, these results provide evidence for no systemic toxicity and the first proof of no basic immunogenic reaction to bone allograft and no sensitization of the recipient.

Complications Following Arthroscopic Ankle Arthrodesis

1996 ◽  
Vol 17 (6) ◽  
pp. 340-342 ◽  
Author(s):  
Lynn A. Crosby ◽  
Ted C. Yee ◽  
Teri S. Formanek ◽  
Timothy C. Fitzgibbons
Keyword(s):  
Bone Marrow ◽  
Complication Rate ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Fusion Rate ◽  
Ankle Arthrodesis ◽  
Deep Infection ◽  
Pin Site ◽  
Demineralized Bone

Forty-two patients underwent an arthroscopic ankle arthrodesis utilizing a bi-framed distraction technique and demineralized bone matrix-bone marrow slurry as a graft substitute. The average follow-up was 27 months (range, 12–64 months). The overall complication rate was 55%, including three nonunions (7%), two fractures (4.8%), four pin site infections (9.5%), one deep infection, four hardware problems (9.5%), and four symptomatic painful subtalar joints (9.5%). Overall, 85% of patients were satisfied with their final result. The complication rate was high but most complications were minor and manageable. The demineralized bone matrix and bone marrow did not seem to increase the fusion rate over what has been documented previously for arthroscopic ankle fusions without the use of this graft substitute.

scholarly journals Demineralized Bone Matrix for Alveolar Cleft Management

2014 ◽  
Vol 7 (4) ◽  
pp. 251-257 ◽  
Author(s):  
Jose Rolando Prada Madrid ◽  
Viviana Gomez ◽  
Bibiana Mendoza
Keyword(s):  
Bone Formation ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Case Series ◽  
Alveolar Cleft ◽  
Case Series Study ◽  
Demineralized Bone

The aim of this article is to describe the results of the use of demineralized bone matrix putty in alveolar cleft of patients with cleft lip and palate. We performed a prospective, descriptive case series study, in which we evaluated the results of the management of alveolar clefts with demineralized bone matrix. Surgery was performed in 10 patients aged between 7 and 26 years (mean 13 years), involving a total of 13 clefts in the 10 patients. A preoperative cone beam computed tomography (CBCT) was taken to the patients in whom the width of the cleft was measured from each edge of the cleft reporting values between 5.76 and 16.93 mm (average, 11.18 mm). The densities of the clefts were measured with a CBCT, 6 months postoperative to assess bone formation. The results showed a register of gray values of 1,148 to 1,396 (mean, 1,270). The follow-up was conducted for 15 to 33 months (mean, 28.2 months). The results did not show satisfactory bone formation in the cleft of patients with the use of demineralized bone matrix.

scholarly journals Two-level contiguous cervical disc disease treated with peek cages packed with demineralized bone matrix: results of 3-year follow-up

2009 ◽  
Vol 18 (2) ◽  
pp. 238-243 ◽  
Author(s):  
Kıvanç Topuz ◽  
Ahmet Çolak ◽  
Serdar Kaya ◽  
Hakan Şimşek ◽  
Murat Kutlay ◽  
...  
Keyword(s):  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Cervical Disc ◽  
Cervical Disc Disease ◽  
Disc Disease ◽  
Demineralized Bone

scholarly journals Does Use of Demineralized Bone Matrix Affect the Union Rate in Arthroscopic Ankle Fusions?

2018 ◽  
Vol 3 (3) ◽  
pp. 2473011418S0036
Author(s):  
Julie Neumann ◽  
Maxwell Weinberg ◽  
Chong Zhang ◽  
Charles Saltzman ◽  
Alexej Barg
Keyword(s):  
Operating Room ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Ankle Arthrodesis ◽  
Rate Of Return ◽  
Secondary Outcome ◽  
Wound Complications ◽  
Union Rate ◽  
Demineralized Bone

Category: Ankle Introduction/Purpose: Despite DBM having positive effects on union rates in other subspecialties of orthopaedics, there is a general lack of evidence about bone graft substitutes in foot and ankle surgery. To our knowledge, orthopaedic surgeons have never evaluated the use of demineralized bone matrix (DBM) as it pertains to the union rate of arthroscopic ankle fusions. The purpose of this clinical study is to compare the rate of union in arthroscopic ankle fusions in patients that have had DBM to those without DBM. The hypothesis of this study was that use of DBM would increase the union rate in all patients undergoing arthroscopic ankle arthrodesis. Methods: This is a retrospective review of 521 consecutive patients from October 2002 to April 2016. Seventy-one ankles from 68 patients met inclusion criteria. These patients underwent primary arthroscopic ankle arthrodesis. Forty patients had DBM and 31 patients did not have DBM. Age, gender, body mass index, smoking, and preoperative radiographic deformity were controlled. The primary outcome measure was union rate of arthroscopic ankle arthrodesis. Secondary outcome measures were time to union, rate of wound complications, rate of return to operating room, and rate of development of post-operative deep vein thrombosis (DVT). Results: Seventy-one patients were available for final follow-up. Average age of the patients was 55.3 +/- 17.6 years. The mean follow-up time was 39.5 months. Unions were assessed on routine post-operative radiographs. If there was a concern for nonunion, patients were further assessed with a computerized tomography scan. Nonunion rate of patients who did have DBM was 7/40 (18%) and nonunion rate of those who did not have DMB was 8/31 (26%) (p=0.40). There was no statistically significant difference between those who did have DBM and those who did not have DBM in wound complication rate (5% vs 6%, p=1.0), rate of return to the operating room (35% vs 39%; p=0.75), and DVT rate (0% vs 0%), respectively. There were no major complications in this study. Conclusion: This study is the largest study to directly compare union rate and complications in patients who had DBM versus those who did not in the setting of arthroscopic ankle fusion. In this study, use of DBM does not affect union rate in patients undergoing arthroscopic ankle arthrodesis. Additionally, use of DBM does not affect the rate of wound complications, return to the operating room, and development of post-operative DVT.

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