Biodegradable polymeric coatings on cochlear implant surfaces and their influence on spiral ganglion cell survival

2014 ◽  
Vol 102 (6) ◽  
pp. 1255-1267 ◽  
Author(s):  
P. Ceschi ◽  
A. Bohl ◽  
K. Sternberg ◽  
A. Neumeister ◽  
V. Senz ◽  
...  
Keyword(s):  
Cochlear Implant ◽  
Ganglion Cell ◽  
Cell Survival ◽  
Spiral Ganglion ◽  
Polymeric Coatings ◽  
Spiral Ganglion Cell

scholarly journals Neurotrophins can enhance spiral ganglion cell survival after inner hair cell loss

1997 ◽  
Vol 15 (4-5) ◽  
pp. 631-643 ◽  
Author(s):  
Josef M. Miller ◽  
David H. Chi ◽  
Leonard J. O'Keeffe ◽  
Paul Kruszka ◽  
Yehoash Raphael ◽  
...  
Keyword(s):  
Hair Cell ◽  
Ganglion Cell ◽  
Cell Survival ◽  
Spiral Ganglion ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Inner Hair Cell ◽  
Spiral Ganglion Cell

scholarly journals Effects of delayed treatment with combined GDNF and continuous electrical stimulation on spiral ganglion cell survival in deafened guinea pigs

2009 ◽  
Vol 87 (6) ◽  
pp. 1389-1399 ◽  
Author(s):  
Verena Scheper ◽  
Gerrit Paasche ◽  
Josef M. Miller ◽  
Athanasia Warnecke ◽  
Nurdanat Berkingali ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Ganglion Cell ◽  
Cell Survival ◽  
Guinea Pigs ◽  
Spiral Ganglion ◽  
Delayed Treatment ◽  
Spiral Ganglion Cell

S240 – Human Cochlear Implant Histopathology

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P155-P155
Author(s):  
Helen Xu ◽  
Natasha Pollak ◽  
Sebahattin Cureoglu ◽  
Michael M Paparella
Keyword(s):  
Cochlear Implant ◽  
Ganglion Cell ◽  
Cell Population ◽  
Ganglion Cells ◽  
Clinical Performance ◽  
Spiral Ganglion ◽  
Spiral Ganglion Cell ◽  
Cell Counts ◽  
Temporal Bones ◽  
Normal Spiral

Objectives 1) To exam the histopathology of multichannel cochlear implant temporal bones. 2) To evaluate the relationship of residual spiral ganglion cell counts to clinical hearing performance. Methods 8 temporal bones from 4 cochlear implant patients were examined histologically. Paired comparisons were made between implanted and nonimplanted temporal bones. Clinical performance data was obtained from patient charts. Results There were varying amounts of inflammation (fibrosis and ossification) in the basal turn of the cochlear in all implanted temporal bones. Trauma to the facial nerve at facial recess site was noticed in 1 case. Compared with nonimplanted ears, 2 implanted bones with less than 10-year duration of implantation had no significant changes of spiral ganglion cell population. One case with prolong implant duration (15 years) showed about 36% decrease of spiral ganglion cells at the implanted site. The case with best speech recognition (89% with CID sentence) had the highest residual spiral ganglion cells (30% of normal spiral ganglion cell population). 2 cases with poor clinical performance (< 10% with CID sentence) had the residual spiral ganglion cells at 11% and 22%. The case with moderate clinical performance (30% with CID sentence) had 14% of normal spiral ganglion cell population. Surviving dendrites varied from 5% to 30% among 4 cases with no relationship to clinical performance. Conclusions Our findings suggest prolonged implantation may affect spiral ganglion cell population. There is no reverse relationship between residual spiral ganglion cells in implanted temporal bones to clinical speech performance observed from our limited cases.

Effect of Cochlear Implantation on Residual Spiral Ganglion Cell Count as Determined by Comparison with the Contralateral Nonimplanted Inner Ear in Humans

2005 ◽  
Vol 114 (5) ◽  
pp. 381-385 ◽  
Author(s):  
Aayesha M. Khan ◽  
Ophir Handzel ◽  
Donald K. Eddington ◽  
Doris Damian ◽  
Joseph B. Nadol
Keyword(s):  
Cochlear Implant ◽  
Ganglion Cell ◽  
Cell Count ◽  
Ganglion Cells ◽  
Spiral Ganglion ◽  
Apical Segment ◽  
Spiral Ganglion Cell ◽  
Cell Counts ◽  
The Mean ◽  
Temporal Bones

It is generally assumed that at least a minimal number of spiral ganglion cells is essential for successful speech perception with a cochlear implant. Although the insertion of a multichannel cochlear implant frequently results in loss of residual hearing in the implanted ear, this outcome does not imply that significant damage to residual populations of spiral ganglion cells has occurred. The purpose of the current study was to compare spiral ganglion cell counts in implanted and nonimplanted cochleas in 11 patients for whom both temporal bones were available and in whom a multichannel cochlear implant had been placed unilaterally. The temporal bones were processed for light microscopy by standard techniques. The cochleas were reconstructed by 2-dimensional methods. Spiral ganglion cell counts of the implanted and nonimplanted sides were compared by a paired t-test (2-tailed). The mean spiral ganglion cell counts for implanted and nonimplanted ears were not statistically different in the most basal three segments of the cochlea. However, the mean spiral ganglion cell count in segment 4 (apical segment) and the mean total spiral ganglion cell count were lower in the implanted cochleas than in the nonimplanted cochleas (p < .01). The results of this study suggest a modest decrease in the total spiral ganglion cell count in the implanted ears as compared to the nonimplanted ears, principally in the apical segment. Possible interpretations of this finding are discussed.

scholarly journals Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival

2014 ◽  
Vol 127 (5) ◽  
pp. 1138-1149 ◽  
Author(s):  
J. A. Coleman ◽  
X. Zhu ◽  
H. R. Djajadi ◽  
L. L. Molday ◽  
R. S. Smith ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Cell Survival ◽  
Spiral Ganglion ◽  
Auditory Function ◽  
Spiral Ganglion Cell ◽  
Phospholipid Flippase
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