A silica-calcium-phosphate nanocomposite drug delivery system for the treatment of hepatocellular carcinoma: In vivo study

2013 ◽  
Vol 102 (1) ◽  
pp. 190-202 ◽  
Author(s):  
Jacob H. Swet ◽  
Hernando J. Pacheco ◽  
David A. Iannitti ◽  
Ahmed El-Ghanam ◽  
Iain H. McKillop
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Calcium Phosphate ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vivo Study

Orthodontic tunnel miniscrews with and without TiO2 nanotube arrays as a drug-delivery system: In vivo study

2016 ◽  
Vol 27 (4) ◽  
pp. 375-387 ◽  
Author(s):  
Bong-Kuen Cha ◽  
Dong-Soon Choi ◽  
Insan Jang ◽  
Byung-Hak Choe ◽  
Won-Youl Choi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tio2 Nanotube Arrays ◽  
Tio2 Nanotube ◽  
In Vivo Study ◽  
Nanotube Arrays

scholarly journals Targeted nano-drug delivery system for glioblastoma therapy: In vitro and in vivo study

2020 ◽  
Vol 60 ◽  
pp. 102039
Author(s):  
Majid Hassanzadeganroudsari ◽  
Majid Soltani ◽  
Amir Heydarinasab ◽  
Vasso Apostolopoulos ◽  
Azim Akbarzadehkhiyavi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vivo Study ◽  
Nano Drug Delivery

scholarly journals Formulation of Insulin Self Nanoemulsifying Drug Delivery System and Its In Vitro-In Vivo Study

2018 ◽  
Vol 29 (3) ◽  
pp. 157
Author(s):  
Lina Winarti ◽  
Suwaldi Suwaldi ◽  
Ronny Martien ◽  
Lukman Hakim
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vivo Study

scholarly journals An in vivo study of Hypericum perforatum in a niosomal topical drug delivery system

Drug Delivery ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 417-425 ◽  
Author(s):  
Mohamed Ali ◽  
Amira Abdel Motaal ◽  
Mohammed A. Ahmed ◽  
Abdulrhman Alsayari ◽  
Omaima N. El-Gazayerly
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hypericum Perforatum ◽  
In Vivo Study ◽  
Topical Drug Delivery

Formulation and Evaluation of Floating Pulsatile Drug Delivery System of Ibuprofen and Ranitidine Combination

2015 ◽  
Vol 8 (4) ◽  
pp. 3009-3017
Author(s):  
Behin Sundara Raj ◽  
I S R Punitha ◽  
M J Gifty
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Lag Time ◽  
Early Morning ◽  
In Vivo Study ◽  
Pulsatile Release ◽  
Pulsatile Drug Delivery ◽  
Core Tablet

Since rheumatoid arthritis patients experience severe pain, inflammation, and joint stiffness in the early morning hours a pulsatile drug delivery system of a suitable anti-inflammatory drug that is administered at bedtime but release the drug in the early morning would be a promising system. The objective of this work was to develop a pulsatile release tablet containing a combination of ibuprofen and ranitidine HCl from which ibuprofen gets released after a lag time of 6-7 hours. The methodology involves; analytical method development for simultaneous estimation of combination drugs, development of pulsatile release tablet and an in vivo study in rats. Lag time was controlled by coating the rapid release core tablet with different grades and concentrations of HPMC polymer. A floating gastroretentive layer was applied on top to prevent metabolism of ranitidine at the last part of the intestine. Six different formulations were prepared with three different concentrations of HPMCK4M and HPMCK100M. In vitro studies showed that the lag time increased with an increase in both concentration and viscosity of polymers. The formulation where the core tablet was coated with 100 mg of HPMCK100M had an optimum lag time of 6.3 hrs. In vivo study evaluated the ulcer protection of the formulation in four animal groups; first group remained as control, the second group received ibuprofen at a dose of 180 mg/kg, third and fourth groups received a combination of both the drugs but ranitidine in different doses. Based on this research, it can be concluded that pulsatile release of ibuprofen tablets can be successfully formulated by using HPMC polymers. The usage of ranitidine along with ibuprofen reduces the ulcerogenecity of the later.

scholarly journals Multiple Targeted Self-Emulsifying Compound RGO Reveals Obvious Antitumor Potential in Hepatocellular Carcinoma

2020 ◽  
Author(s):  
Sanxiu He ◽  
Shaorong Tian ◽  
Xin Le ◽  
Jialin Chen ◽  
Hongyi Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Cell Proliferation ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ganoderma Lucidum ◽  
Toxicity Tests ◽  
Migration And Invasion ◽  
Advanced Hepatocellular Carcinoma

Abstract Background: Currently, the treatment for advanced hepatocellular carcinoma (HCC) is extremely limited. Ginsenoside Rg3, ganoderma lucidum polysaccharide, and Oridonin have shown great potential in anti-tumor therapy in previous studies, but low bioavailability and poor solubility seriously hinder their clinical application. Hence, new strategy for liver cancer are urgently needed. Methods: Cell viability, cell proliferation, cell migration, colony formation, tubule formation, sphere formation, and flow cytometry were used to assess the effect of a new drug, RGO-SMEDDS, (self-microemulsifying drug delivery system comprising of Rg3, ganoderma lucidum polysaccharide, and Oridonin) on HCC. Specific anti-tumor mechanisms of RGO-SMEDDS were investigated by western blot, qRT-PCR, and immunohistochemistry. Xenografts and staining with hematoxylin and eosin were used to assess the effects of RGO-SMEDDS on tumorigenesis in vivo.Results: We developed a self-microemulsifying drug delivery system (RGO-SMEDDS) for these three plant monomers. Treatment with RGO-SMEDDS resulted in induction of G2/M phase arrest and apoptosis, inhibition of migration and invasion, and suppression of cell proliferation, both in vitro and in vivo. Furthermore, RGO-SMEDDS restored immune function by suppressing the production of immunosuppressive cytokine and M2-polarized macrophages, reduced angiogenesis by down-regulation of vascular endothelial growth factor and its receptor, and attenuated stemness of HCC by inhibiting EGFR/AKT/GSK-3α/β signaling pathways. In addition to excellent anti-tumor effects, RGO-SMEDDS showed considerable safety in acute toxicity tests.Conclusion: RGO-SMEDDS exerted significant anti-tumor effects by reducing angiogenesis, remodeling immune microenvironments, and promoting apoptosis, without obvious toxicities. With these attributes RGO-SMEDDS is a promising therapy for the treatment of hepatocellular carcinoma.

Positively charged cholesterol derivative combined with liposomes as an efficient drug delivery system, in vitro and in vivo study

Soft Matter ◽  
2012 ◽  
Vol 8 (2) ◽  
pp. 518-525 ◽  
Author(s):  
Bin Yang ◽  
Sheng-Yong Geng ◽  
Xin-Ming Liu ◽  
Jian-Tao Wang ◽  
Yong-Kui Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vivo Study ◽  
Cholesterol Derivative ◽  
Positively Charged

108 EVALUATION OF A NOVEL BIOCERAMIC DRUG DELIVERY SYSTEM FOR TREATING HEPATOCELLULAR CARCINOMA (HCC) IN VIVO

2012 ◽  
Vol 56 ◽  
pp. S48
Author(s):  
J. Swet ◽  
K. Simo ◽  
H. Pacheco ◽  
D. Sindram ◽  
D. Iannitti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System
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