scholarly journals In vitro analysis of the cytotoxic and anti‐inflammatory effects of antioxidant compounds used as additives in ultra high‐molecular weight polyethylene in total joint replacement components

2012 ◽  
Vol 101B (3) ◽  
pp. 407-413 ◽  
Author(s):  
C. L. Bladen ◽  
L. Tzu‐Yin ◽  
J. Fisher ◽  
J. L. Tipper
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Joint Replacement ◽  
Total Joint Replacement ◽  
Antioxidant Compounds ◽  
Anti Inflammatory ◽  
Vitro Analysis ◽  
Ultra High Molecular Weight ◽  
In Vitro Analysis

Computational Analysis of Microstructure of Ultra High Molecular Weight Polyethylene for Use in Total Joint Replacement

2012 ◽  
Author(s):  
Kelly M. Seymour ◽  
Sara A. Atwood
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Joint Replacement ◽  
Hip Replacement ◽  
Computational Analysis ◽  
Total Joint Replacement ◽  
Cause Of Failure ◽  
Ultra High Molecular Weight

Ultra-High Molecular Weight Polyethylene, or UHMWPE, is a material commonly used as a bearing between metal components of a knee or hip replacement joint. The ultra-high component is frequently the cause of failure of the joint due to wear, fatigue, or fracture [1,2].

scholarly journals Prediction aided in vitro analysis of octadecanoic acid from Cyanobacterium Lyngbya sp. as a proapoptotic factor in eliciting anti-inflammatory properties

2017 ◽  
Vol 13 (09) ◽  
pp. 301-306
Author(s):  
Paramasivan Manivannan ◽  
◽  
Gangatharan Muralitharan ◽  
Nainangu Prasanna Balaji ◽  
◽  
...  
Keyword(s):  
Octadecanoic Acid ◽  
Anti Inflammatory ◽  
Vitro Analysis ◽  
In Vitro Analysis

scholarly journals Anti-Inflammatory Formulation and Characterization of an Herbal Formulation

2021 ◽  
pp. 51-57
Author(s):  
Snigdha Pattnaik ◽  
Laxmidhar Moharana
Keyword(s):  
Pain Reduction ◽  
Inflammatory Activity ◽  
Topical Gel ◽  
Herbal Formulation ◽  
Characterization Studies ◽  
Anti Inflammatory ◽  
Vitro Analysis ◽  
In Vitro Analysis

Anti-inflammatory refers to group of medication that is utilized for curing pain and inflammation. Many synthetic products are used as anti-inflammatory agents but the effects caused by them is not satisfactory. Cordis obliqua is an anti-inflammatory herb that is enormously involved in pain reduction. The present paper aims to develop a topical gel formulation comprising herbs i.e. Cordis obliqua and curcumin with potent anti-inflammatory activity. The gel formulation was then subjected to characterization studies which involve pH, viscosity, excrudability, spreadability and in vitro analysis. pH of gel formulation was found to be 7.2±1.01 which is almost equivalent to the skin pH. In viscosity test, it was observed that viscosity of gel formulation was found to be effective. Moreover, spreadability co-efficient of the formulation satisfactory which indicates that sanitizer gel easily adhers on the skin and covers the bacteria residing on the skin, if any.

scholarly journals The Genotoxicity of Caecal Water in Gilts Exposed to Low Doses of Zearalenone

Toxins ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 350 ◽  
Author(s):  
Katarzyna Cieplińska ◽  
Magdalena Gajęcka ◽  
Adriana Nowak ◽  
Michał Dąbrowski ◽  
Łukasz Zielonka ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Water Samples ◽  
Control Group ◽  
Low Molecular Weight ◽  
Low Doses ◽  
Vitro Analysis ◽  
Compensatory Effect ◽  
Control Group Group ◽  
In Vitro Analysis

Zearalenone is a toxic low-molecular-weight molecule that is naturally produced by moulds on crops as a secondary metabolite. The aim of this study was to determine the genotoxicity of caecal water collected successively from the caecal contents of gilts exposed to low doses (LOAEL, NOAEL, and MABEL) of zearalenone. The experiment was performed on 60 clinically healthy gilts with average BW of 14.5 ± 2 kg, divided into three experimental groups and a control group. Group ZEN5 were orally administered ZEN at 5 μg/kg BW, group ZEN10—10 μg ZEN/kg BW and group ZEN15—15 µg ZEN/kg BW. Five gilts from every group were euthanized on analytical dates 1, 2, and 3. Caecal water samples for in vitro analysis were collected from the ileocaecal region. The genotoxicity of caecal water was noted, particularly after date 1 in groups ZEN10 and ZEN15 with a decreasing trend. Electrophoresis revealed the presence of numerous comets without tails in groups C and ZEN5 and fewer comets with clearly expressed tails in groups ZEN10 and ZEN15. The distribution of LLC-PK1 cells ranged from 15% to 20% in groups C and ZEN5, and from 30% to 60% in groups ZEN10 and ZEN15. The analysis of caecal water genotoxicity during exposure to very low doses of ZEN revealed the presence of a counter response and a compensatory effect in gilts.

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