In vitro and in vivo study of calcium polyphosphate fiber/calcium phosphate cement/micromorselized bone composite for bone defect repair

2012 ◽  
Vol 100B (5) ◽  
pp. 1190-1197 ◽  
Author(s):  
Lei Zhou ◽  
Chun J. Hu ◽  
Gong P. Xu ◽  
Jing L. Yan
Keyword(s):  
Calcium Phosphate ◽  
Bone Defect ◽  
Calcium Phosphate Cement ◽  
In Vivo Study ◽  
Bone Defect Repair ◽  
Calcium Polyphosphate ◽  
Defect Repair

scholarly journals The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds

RSC Advances ◽  
2020 ◽  
Vol 10 (13) ◽  
pp. 7708-7717 ◽  
Author(s):  
Rong Zhou ◽  
Hai-Jian Ni ◽  
Jin-Hui Peng ◽  
Ning Liu ◽  
Shu Chen ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Drug Release ◽  
Bone Defect ◽  
High Performance ◽  
Calcium Phosphates ◽  
Sustained Drug Release ◽  
Bone Defect Repair ◽  
Defect Repair

Calcium phosphate modified tantalum scaffolds displayed high performance on mineralization, sustained drug release and in vivo bone defect repair.

scholarly journals Stabilizing dental implants with a fiber-reinforced calcium phosphate cement: An in vitro and in vivo study

2020 ◽  
Vol 110 ◽  
pp. 280-288
Author(s):  
Sónia de Lacerda Schickert ◽  
John A Jansen ◽  
Ewald M. Bronkhorst ◽  
Jeroen JJP van den Beucken ◽  
Sander CG Leeuwenburgh
Keyword(s):  
Calcium Phosphate ◽  
Dental Implants ◽  
Calcium Phosphate Cement ◽  
In Vivo Study ◽  
Fiber Reinforced

scholarly journals In Vivo and in Vitro Studies of the Effect of Chitosan on the Bone Defect Repair Process

2016 ◽  
Vol 16 (2) ◽  
pp. 171-179 ◽  
Author(s):  
I. V. Zudina ◽  
◽  
A. P. Vedyaeva ◽  
P. V. Ivanov ◽  
A. F. A. Alzubaidi ◽  
...  
Keyword(s):  
Bone Defect ◽  
Repair Process ◽  
In Vitro Studies ◽  
Bone Defect Repair ◽  
Defect Repair

scholarly journals Tuning filament composition and microstructure of 3D-printed bioceramic scaffolds facilitate bone defect regeneration and repair

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Yi Chen ◽  
Jiaping Huang ◽  
Jiamei Liu ◽  
Yingming Wei ◽  
Xianyan Yang ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Defect ◽  
Core Shell ◽  
Shell Layer ◽  
Ion Release ◽  
Component Distribution ◽  
Bone Defect Repair ◽  
Defect Repair

Abstract It is still a challenge to optimize the component distribution and microporous structures in scaffolds for tailoring biodegradation (ion releasing) and enhancing bone defect repair within an expected time stage. Herein, the core–shell-typed nonstoichiometric wollastonite (4% and 10% Mg-doping calcium silicate; CSiMg4, CSiMg10) macroporous scaffolds with microporous shells (adding ∼10 μm PS microspheres into shell-layer slurry) were fabricated via 3D printing. The initial mechanical properties and bio-dissolution (ion releasing) in vitro, and osteogenic capacity in vivo of the bioceramic scaffolds were evaluated systematically. It was shown that endowing high-density micropores in the sparingly dissolvable CSiMg10 or dissolvable CSiMg4 shell layer inevitably led to nearly 30% reduction of compressive strength, but such micropores could readily tune the ion release behaviour of the scaffolds (CSiMg4@CSiMg10 vs. CSiMg4@CSiMg10-p; CSiMg10@CSiMg4 vs. CSiMg10@CSiMg4-p). Based on the in rabbit femoral bone defect repair model, the 3D μCT reconstruction and histological observation demonstrated that the CSiMg4@CSiMg10-p scaffolds displayed markedly higher osteogenic capability than the other scaffolds after 12 weeks of implantation. It demonstrated that core–shell bioceramic 3D printing technique can be developed to fabricate single-phase or biphasic bioactive ceramic scaffolds with accurately tailored filament biodegradation for promoting bone defect regeneration and repair in some specific pathological conditions.

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