Swelling properties of copolymeric hydrogels of poly(ethylene glycol) monomethacrylate and monoesters of itaconic acid for use in drug delivery

2009 ◽  
Vol 91B (2) ◽  
pp. 716-726 ◽  
Author(s):  
César Teijón ◽  
Sandra Guerrero ◽  
Rosa Olmo ◽  
José M. Teijón ◽  
M. Dolores Blanco
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Itaconic Acid ◽  
Poly Ethylene Glycol ◽  
Swelling Properties ◽  
Poly Ethylene

scholarly journals Hemocompatibility and swelling studies of poly(2-hydroxyethyl methacrylate-co-itaconic acid-co-poly(ethylene glycol) dimethacrylate) hydrogels

2011 ◽  
Vol 65 (6) ◽  
pp. 675-685 ◽  
Author(s):  
Sava Dobic ◽  
Jovana Jovasevic ◽  
Marija Vojisavljevic ◽  
Simonida Tomic
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Cell Viability ◽  
Itaconic Acid ◽  
Hydroxyethyl Methacrylate ◽  
Poly Ethylene Glycol ◽  
Swelling Properties ◽  
Swelling Studies ◽  
Poly Ethylene

In this study novel series of hydrogels, based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and poly(ethylene glycol) dimethacrylates (PEGDMA) (of varying molecular weight and concentration) were prepared by free radical crosslinking copolymerization. Preliminary hemocompatibility characterization of hydrogels obtained by hemolytic activity assay indicated good compatibility with blood. Preliminary biocompatibility characterization of P(HEMA/IA/PEGDMA) hydrogels, done by the cytotoxicity assays using the HeLa cell line revails that the cell viability of all samples was the range of 97?100%, with no significant decrease in cell viability with the change of PEGDMA molecular weight and concentration. Swelling studies were conducted for all P(HEMA/IA/PEGDMA) samples in a physiological pH and temperature range and network parameters were determined. Swelling studies showed pH sensitive behaviour, typical for anionic hydrogels, and temperature dependent swelling. The effects of concentration of PEGDMA component on hydrogel swelling properties depend on the PEGDMA molecular weight. The samples with 550PEGDMA show different swelling capacities when 550PEGDMA content is changed, whereas for P(HEMA/IA/875PEGDMA) samples there was practically no difference in equilibrium degree of swelling, qe ,with varying 875PEGDMA content, which trend is the same as in the case of qe versus pH dependences. It was concluded that P(HEMA/IA/PEGDMA) hydrogels show good potential to be used as biomedical materials.

pH-Sensitive Poly(itaconic acid)-poly(ethylene glycol)-poly(L-histidine) Micelles for Drug Delivery

2015 ◽  
Vol 52 (11) ◽  
pp. 925-933 ◽  
Author(s):  
Yuan Sun ◽  
Yapeng Li ◽  
Hailong Huang ◽  
Yuzhen Wang ◽  
Zongpeng Sa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Itaconic Acid ◽  
Ph Sensitive ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

Recent development of poly(ethylene glycol)-cholesterol conjugates as drug delivery systems

2014 ◽  
Vol 469 (1) ◽  
pp. 168-178 ◽  
Author(s):  
Zhi-Yao He ◽  
Bing-Yang Chu ◽  
Xia-Wei Wei ◽  
Jiao Li ◽  
Carl K. Edwards ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Controlled Release of Proteins from Their Poly(Ethylene Glycol) Conjugates:  Drug Delivery Systems Employing 1,6-Elimination

2003 ◽  
Vol 14 (2) ◽  
pp. 395-403 ◽  
Author(s):  
Richard B. Greenwald ◽  
Karen Yang ◽  
Hong Zhao ◽  
Charles D. Conover ◽  
Stanford Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Ethylene Glycol ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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