A composite scaffold of PLGA microspheres/fibrin gel for cartilage tissue engineering: Fabrication, physical properties, and cell responsiveness

2009 ◽  
Vol 88B (1) ◽  
pp. 240-249 ◽  
Author(s):  
Haiguang Zhao ◽  
Lie Ma ◽  
Changyou Gao ◽  
Jiacong Shen
Keyword(s):  
Tissue Engineering ◽  
Physical Properties ◽  
Composite Scaffold ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Plga Microspheres ◽  
Fibrin Gel

Biodegradable insulin-loaded PLGA microspheres fabricated by three different emulsification techniques: Investigation for cartilage tissue engineering

2011 ◽  
Vol 7 (4) ◽  
pp. 1485-1495 ◽  
Author(s):  
Kristin Andreas ◽  
Rolf Zehbe ◽  
Maja Kazubek ◽  
Karolina Grzeschik ◽  
Nadine Sternberg ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Plga Microspheres

scholarly journals Thermogel-Coated Poly(ε-Caprolactone) Composite Scaffold for Enhanced Cartilage Tissue Engineering

Polymers ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 200 ◽  
Author(s):  
Shao-Jie Wang ◽  
Zheng-Zheng Zhang ◽  
Dong Jiang ◽  
Yan-Song Qi ◽  
Hai-Jun Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Composite Scaffold ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue

scholarly journals A novel nano-composite scaffold for cartilage tissue engineering

2017 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
M. Mehdikhani-Nahrkhalaji ◽  
E. Tavakoli ◽  
A. Zargar-Kharazi ◽  
B. Hashemi-Beni
Keyword(s):  
Tissue Engineering ◽  
Composite Scaffold ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Nano Composite

scholarly journals Applications of Hydrogel with Special Physical Properties in Bone and Cartilage Regeneration

Materials ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 235
Author(s):  
Hua Lin ◽  
Cuilan Yin ◽  
Anchun Mo ◽  
Guang Hong
Keyword(s):  
Tissue Engineering ◽  
Physical Properties ◽  
Cartilage Tissue Engineering ◽  
Antibacterial Properties ◽  
High Strength ◽  
Cartilage Regeneration ◽  
Cartilage Tissue ◽  
Medical Progress ◽  
Extracellular Matrix Components ◽  
And Cartilage

Hydrogel is a polymer matrix containing a large amount of water. It is similar to extracellular matrix components. It comes into contact with blood, body fluids, and human tissues without affecting the metabolism of organisms. It can be applied to bone and cartilage tissues. This article introduces the high-strength polymer hydrogel and its modification methods to adapt to the field of bone and cartilage tissue engineering. From the perspective of the mechanical properties of hydrogels, the mechanical strength of hydrogels has experienced from the weak-strength traditional hydrogels to the high-strength hydrogels, then the injectable hydrogels were invented and realized the purpose of good fluidity before the use of hydrogels and high strength in the later period. In addition, specific methods to give special physical properties to the hydrogel used in the field of bone and cartilage tissue engineering will also be discussed, such as 3D printing, integrated repair of bone and cartilage tissue, bone vascularization, and osteogenesis hydrogels that regulate cell growth, antibacterial properties, and repeatable viscosity in humid environments. Finally, we explain the main reasons and contradictions in current applications, look forward to the research prospects in the field of bone and cartilage tissue engineering, and emphasize the importance of conducting research in this field to promote medical progress.

scholarly journals PLGA/COL I Composite Scaffold Printed by a Low-temperature Deposition Manufacturing Technique for Application to Cartilage Tissue Engineering

2020 ◽  
Author(s):  
Liangquan Peng ◽  
Yong He ◽  
Weimin Zhu ◽  
Wei Lu ◽  
Yong Huang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Low Temperature ◽  
Composite Scaffold ◽  
Cartilage Tissue Engineering ◽  
Three Dimensional ◽  
Cartilage Tissue ◽  
Composite Scaffolds ◽  
Low Temperature Deposition ◽  
Temperature Deposition

Abstract Background Composite scaffolds of poly(lactic-co-glycolic acid) (PLGA) and PLGA/COL I were developed by a low-temperature deposition manufacturing (LDM) technique using three-dimensional printing technology. Their physical properties were tested, and the scaffolds were then used as cell culture platforms to prepare an ideal scaffold for cartilage tissue engineering. Methods The LDM technique was used to fabricate PLGA and PLGA/COL I composite scaffolds. The macrostructure, micromorphology, porosity, hydrophobicity, mechanical properties, and chemical structure of these scaffolds were examined. Primary chondrocytes were isolated and identified, second-passage cells were seeded onto the two scaffolds, and the adhesion and proliferation of the cells were determined. Results Both the PLGA and PLGA/COL I scaffolds prepared by LDM displayed a regular three-dimensional structure with high porosity. The PLGA scaffold had better mechanical properties than the PLGA/COL I scaffold, while the latter had significantly higher hydrophilicity than the former. The PLGA/COL I scaffold cultured with chondrocytes exhibited a higher adhesion rate and proliferation rate than the PLGA/COL I scaffold. Conclusion The novel PLGA/COL I composite scaffold printed by the LDM technique exhibited favourable biocompatibility and biomechanical characteristics and could be a good candidate for cartilage tissue engineering.

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