Self-assembling peptide nanofibers and skeletal myoblast transplantation in infarcted myocardium

2008 ◽  
Vol 87B (1) ◽  
pp. 222-228 ◽  
Author(s):  
Gilbert Dubois ◽  
Vincent F. M. Segers ◽  
Valérie Bellamy ◽  
Laurent Sabbah ◽  
Séverine Peyrard ◽  
...  
Keyword(s):  
Skeletal Myoblast ◽  
Infarcted Myocardium ◽  
Self Assembling ◽  
Peptide Nanofibers ◽  
Myoblast Transplantation

Skeletal myoblast transplantation through a catheter-based coronary sinus approach: an effective means of improving function of infarcted myocardium

2005 ◽  
Vol 26 (15) ◽  
pp. 1551-1556 ◽  
Author(s):  
Camille Brasselet ◽  
Miguel Cortes Morichetti ◽  
Emmanuel Messas ◽  
Claire Carrion ◽  
Alvine Bissery ◽  
...  
Keyword(s):  
Coronary Sinus ◽  
Effective Means ◽  
Skeletal Myoblast ◽  
Infarcted Myocardium ◽  
Myoblast Transplantation

Autologous skeletal myoblast transplantation attenuates left ventricular dilatation without improving cardiac function

2003 ◽  
Vol 9 (5) ◽  
pp. S1
Author(s):  
Patrick I. McConnell ◽  
Louis Astra ◽  
E.William Schneeberger ◽  
Doug Jacoby ◽  
Jonathan Dinsmore ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Left Ventricular ◽  
Ventricular Dilatation ◽  
Skeletal Myoblast ◽  
Left Ventricular Dilatation ◽  
Myoblast Transplantation

scholarly journals Intramyocardial microdepot injection increases the efficacy of skeletal myoblast transplantation

2005 ◽  
Vol 27 (6) ◽  
pp. 1017-1021 ◽  
Author(s):  
H OTT ◽  
R KROESS ◽  
N BONAROS ◽  
R MARKSTEINER ◽  
E MARGREITER ◽  
...  
Keyword(s):  
Skeletal Myoblast ◽  
Myoblast Transplantation

scholarly journals Does the Functional Efficacy of Skeletal Myoblast Transplantation Extend to Nonischemic Cardiomyopathy?

Circulation ◽  
2004 ◽  
Vol 110 (12) ◽  
pp. 1626-1631 ◽  
Author(s):  
Julia Pouly ◽  
Albert A. Hagège ◽  
Jean-Thomas Vilquin ◽  
Alvine Bissery ◽  
Andrée Rouche ◽  
...  
Keyword(s):  
Nonischemic Cardiomyopathy ◽  
Skeletal Myoblast ◽  
Myoblast Transplantation

Heat Shock Treatment Enhances Graft Cell Survival in Skeletal Myoblast Transplantation to the Heart

Circulation ◽  
2000 ◽  
Vol 102 (suppl_3) ◽  
Author(s):  
Ken Suzuki ◽  
Ryszard T. Smolenski ◽  
Jay Jayakumar ◽  
Bari Murtuza ◽  
Nigel J. Brand ◽  
...  
Keyword(s):  
Heat Shock ◽  
Cell Survival ◽  
Cell Transplantation ◽  
Shock Treatment ◽  
Heat Shock Treatment ◽  
Skeletal Myoblast ◽  
Skeletal Myoblasts ◽  
Myoblast Transplantation ◽  
Hypoxia Reoxygenation

Background —Graft survival after skeletal myoblast transplantation is affected by various pathological processes caused by environmental stress. Heat shock is known to afford protection of several aspects of cell metabolism and function. We hypothesized that prior heat shock treatment of graft cells would improve their survival after cell transplantation. Methods and Results —L6 rat skeletal myoblasts expressing β-galactosidase (β-gal) were subjected to heat shock (42°C, 1 hour). Increased expression of heat shock protein 72 was detected 24 hours later in the heat-shocked cells. After hypoxia-reoxygenation in vitro, lactate dehydrogenase leakage was significantly attenuated in the heat-shocked cells; in addition, the percentage of early apoptosis was lower in this group measured by flow cytometry with annexin V staining. For the in vivo study, 1×10 6 heat-shocked (hsCTx) or normal-cultured (CTx) myoblasts were infused into the explanted rat hearts through the coronary artery followed by heterotopic heart transplantation. β-gal activity was significantly higher in the hsCTx group after cell transplantation, with an estimated 8×10 6 surviving cells per heart in the hsCTx group and 5×10 6 cells in the CTx group on day 28. Discrete loci of grafted cells were globally observed in the myocardium of the hsCTx and CTx groups, with a higher frequency in the hsCTx group. Surviving myoblasts occasionally differentiated into myotubes and had integrated with the native cardiomyocytes. Conclusions —Heat-shocked skeletal myoblasts demonstrated improved tolerance to hypoxia-reoxygenation insult in vitro and enhanced survival when grafted into the heart. Heat shock treatment could be useful in improving graft cell survival in cell transplantation.

Regenerating functional myocardium: Improved performance after skeletal myoblast transplantation

1998 ◽  
Vol 4 (8) ◽  
pp. 929-933 ◽  
Author(s):  
Doris A. Taylor ◽  
B. Zane Atkins ◽  
Pinata Hungspreugs ◽  
Thomas R. Jones ◽  
Mary C. Reedy ◽  
...  
Keyword(s):  
Skeletal Myoblast ◽  
Improved Performance ◽  
Myoblast Transplantation
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