Preparation and characterization of infection-resistant antibiotics-releasing hydrogels rods of poly[hydroxyethyl methacrylate-co-(poly(ethylene glycol)-methacrylate]: Biomedical application in a novel rabbit penile prosthesis model

2008 ◽  
Vol 86B (1) ◽  
pp. 18-28 ◽  
Author(s):  
M. Yakup Arıca ◽  
Devrim Tuğlu ◽  
M. Murad Başar ◽  
Dilek Kılıç ◽  
Gülay Bayramoğlu ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Biomedical Application ◽  
Penile Prosthesis ◽  
Hydroxyethyl Methacrylate ◽  
Poly Ethylene Glycol ◽  
Glycol Methacrylate ◽  
Poly Ethylene

scholarly journals Hemocompatibility and swelling studies of poly(2-hydroxyethyl methacrylate-co-itaconic acid-co-poly(ethylene glycol) dimethacrylate) hydrogels

2011 ◽  
Vol 65 (6) ◽  
pp. 675-685 ◽  
Author(s):  
Sava Dobic ◽  
Jovana Jovasevic ◽  
Marija Vojisavljevic ◽  
Simonida Tomic
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Cell Viability ◽  
Itaconic Acid ◽  
Hydroxyethyl Methacrylate ◽  
Poly Ethylene Glycol ◽  
Swelling Properties ◽  
Swelling Studies ◽  
Poly Ethylene

In this study novel series of hydrogels, based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and poly(ethylene glycol) dimethacrylates (PEGDMA) (of varying molecular weight and concentration) were prepared by free radical crosslinking copolymerization. Preliminary hemocompatibility characterization of hydrogels obtained by hemolytic activity assay indicated good compatibility with blood. Preliminary biocompatibility characterization of P(HEMA/IA/PEGDMA) hydrogels, done by the cytotoxicity assays using the HeLa cell line revails that the cell viability of all samples was the range of 97?100%, with no significant decrease in cell viability with the change of PEGDMA molecular weight and concentration. Swelling studies were conducted for all P(HEMA/IA/PEGDMA) samples in a physiological pH and temperature range and network parameters were determined. Swelling studies showed pH sensitive behaviour, typical for anionic hydrogels, and temperature dependent swelling. The effects of concentration of PEGDMA component on hydrogel swelling properties depend on the PEGDMA molecular weight. The samples with 550PEGDMA show different swelling capacities when 550PEGDMA content is changed, whereas for P(HEMA/IA/875PEGDMA) samples there was practically no difference in equilibrium degree of swelling, qe ,with varying 875PEGDMA content, which trend is the same as in the case of qe versus pH dependences. It was concluded that P(HEMA/IA/PEGDMA) hydrogels show good potential to be used as biomedical materials.

scholarly journals Swelling Behavior and Nanomechanical Properties of (Peptide-Modified) Poly(2-hydroxyethyl methacrylate) and Poly(poly(ethylene glycol) methacrylate) Brushes

2016 ◽  
Vol 49 (12) ◽  
pp. 4609-4618 ◽  
Author(s):  
Solenne Desseaux ◽  
Juan Pablo Hinestrosa ◽  
Nicolas Schüwer ◽  
Bradley S. Lokitz ◽  
John F. Ankner ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Swelling Behavior ◽  
Hydroxyethyl Methacrylate ◽  
Poly Ethylene Glycol ◽  
Nanomechanical Properties ◽  
Glycol Methacrylate ◽  
Poly Ethylene
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