In vitro degradation and in vivo biocompatibility of poly(lactic acid) mesh for soft tissue reinforcement in vaginal surgery

2008 ◽  
Vol 85B (2) ◽  
pp. 529-536 ◽  
Author(s):  
Renaud de Tayrac ◽  
Samir Chentouf ◽  
Henri Garreau ◽  
Christian Braud ◽  
Isabelle Guiraud ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Soft Tissue ◽  
Vaginal Surgery ◽  
Poly Lactic Acid ◽  
In Vitro Degradation

scholarly journals In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 29
Author(s):  
Seung Kyun Yoon ◽  
Jin Ho Yang ◽  
Hyun Tae Lim ◽  
Young-Wook Chang ◽  
Muhammad Ayyoob ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Animal Experiments ◽  
Polymeric Materials ◽  
Polyglycolic Acid ◽  
Poly Lactic Acid ◽  
Skin Sensitization ◽  
Spinal Fixation ◽  
In Vivo Degradation

Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials.

In vitro degradation of dry-jet-wet spun poly(lactic acid) monofilament and knitted scaffold

2006 ◽  
Vol 103 (3) ◽  
pp. 2006-2012 ◽  
Author(s):  
Bhuvanesh Gupta ◽  
Nilesh Revagade ◽  
Jöns Hilborn
Keyword(s):  
Lactic Acid ◽  
Poly Lactic Acid ◽  
In Vitro Degradation

In vitro degradation of porous poly(lactic acid)/quantum dots scaffolds

2013 ◽  
Vol 55 ◽  
pp. 234-239 ◽  
Author(s):  
Xinghou Gong ◽  
Chak Yin Tang ◽  
Ling Pan ◽  
Zhonghua Hao ◽  
Chi Pong Tsui ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Lactic Acid ◽  
Poly Lactic Acid ◽  
In Vitro Degradation ◽  
Porous Poly

In vitro and in vivo release of insulin from poly(lactic acid) microbeads and pellets

1986 ◽  
Vol 4 (1) ◽  
pp. 47-62 ◽  
Author(s):  
A.K. Kwong ◽  
S. Chou ◽  
A.M. Sun ◽  
M.V. Sefton ◽  
M.F.A. Goosen
Keyword(s):  
Lactic Acid ◽  
Poly Lactic Acid ◽  
In Vivo Release

scholarly journals Biocompatible Materials Based on Plasticized Poly(lactic acid), Chitosan and Rosemary Ethanolic Extract I. Effect of Chitosan on the Properties of Plasticized Poly(lactic acid) Materials

Polymers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 941 ◽  
Author(s):  
Cornelia Vasile ◽  
Elena Stoleru ◽  
Raluca Nicoleta Darie-Niţa ◽  
Raluca Petronela Dumitriu ◽  
Daniela Pamfil ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Food Packaging ◽  
Polymeric Materials ◽  
Poly Lactic Acid ◽  
Rosemary Extract ◽  
Antioxidant Compounds ◽  
Innovative Drug ◽  
Melt Mixing

The purpose of the present study is to develop new multifunctional environmentally friendly materials having applications both in medical and food packaging fields. New poly(lactic acid) (PLA)-based multifunctional materials containing additives derived from natural resources like chitosan (CS) and rosemary extract (R) were obtained by melt mixing. Each of the selected components has its own specific properties such as: PLA is a biodegradable thermoplastic aliphatic polyester derived from renewable biomass, heat-resistant, with mechanical properties close to those of polystyrene and polyethylene terephthalate, and CS offers good antimicrobial activity and biological functions, while R significantly improves antioxidative action necessary in all applications. A synergy of their combination, an optimum choice of their ratio, and processing parameters led to high performance antimicrobial/antioxidant/biocompatible/environmentally degradable materials. The polyethylene glycol (PEG)-plasticized PLA/chitosan/powdered rosemary extract biocomposites of various compositions were characterized in respect to their mechanical and rheological properties, structure by spectroscopy, antioxidant and antimicrobial activities, and in vitro and in vivo biocompatibility. Scanning electron microscopy images evidence the morphology features added by rosemary powder presence in polymeric materials. Incorporation of additives improved elongation at break, antibacterial and antioxidant activity and also biocompatibility. Migration of bioactive components into D1 simulant is slower for PEG-plasticized PLA containing 6 wt % chitosan and 0.5 wt % rosemary extract (PLA/PEG/6CS/0.5 R) biocomposite and it occurred by a diffusion-controlled mechanism. The biocomposites show high hydrophilicity and good in vitro and in vivo biocompatibility. No hematological, biochemical and immunological modifications are induced by subcutaneous implantation of biocomposites. All characteristics of the PEG-plasticized PLA-based biocomposites recommend them as valuable materials for biomedical implants, and as well as for the design of innovative drug delivery systems. Also, the developed biocomposites could be a potential nature-derived active packaging with controlled release of antimicrobial/antioxidant compounds.

scholarly journals In vitro and in vivo properties study of a novel 3D-printed absorbable pancreaticojejunostomy device made by melting blended poly(p-dioxanone)/poly(lactic acid)

2021 ◽  
Vol 210 ◽  
pp. 110088
Author(s):  
Maoen Pan ◽  
Zeya Xu ◽  
Wei Luo ◽  
Yuanyuan Yang ◽  
Tianhong Teng ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Poly Lactic Acid ◽  
3D Printed
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