Development of a 95/5 poly(L-lactide-co-glycolide)/hydroxylapatite and β-tricalcium phosphate scaffold as bone replacement material via selective laser sintering

2007 ◽  
Vol 84B (1) ◽  
pp. 17-25 ◽  
Author(s):  
Rebecca Louise Simpson ◽  
Florencia Edith Wiria ◽  
Andrew A. Amis ◽  
Chee Kai Chua ◽  
Kah Fai Leong ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Bone Replacement Material ◽  
Bone Replacement

Manufacture and Characterisation of Bioceramic Tissue Engineering Scaffolds Produced by Selective Laser Sintering

2007 ◽  
Author(s):  
K. Xiao ◽  
J. A. Dyson ◽  
K. W. Dalgarno ◽  
P. Genever ◽  
D. J. Wood ◽  
...  
Keyword(s):  
Glass Ceramic ◽  
Selective Laser Sintering ◽  
Human Mesenchymal Stem Cells ◽  
Biological Properties ◽  
Laser Sintering ◽  
Process Conditions ◽  
Tissue Engineering Scaffolds ◽  
Process Maps ◽  
Bone Replacement ◽  
Porous Bioceramic

Currently there is no adequate bone replacement available that combines a long implant life with complete integration and appropriate mechanical properties. This paper reports on the use of human mesenchymal stem cells (MSCs) to populate porous bioceramic scaffolds produced by selective laser sintering (SLS) to create bespoke bioactive bone replacement structures. Apatite-wollastonite glass ceramic was chosen for use in this study because of its combination of excellent mechanical and biological properties, and has been processed using an indirect SLS approach. Process maps have been developed to identify process conditions for the SLS stage of manufacture and an optimised furnace cycle for the material has been developed to ensure that the required material phases for bioactivity are present in the manufactured scaffold. Results from tissue culture with the MSC’s on the scaffolds (using confocal and scanning electron microscopy) show that MSCs adhere, spread and retain viability on the surface, and penetrate into the pores of apatite wollastonite (A-W) glass ceramic scaffolds over a 21 day culture period. The MSC’s also show strong indications of osteogenesis, indicating that the MSC’s are differentiating to osteoblasts. These results indicate good biocompatibility and osteo supportive capacity of SLS generated A-W scaffolds and excellent potential in bone replacement applications.

In vitrobioactivity and degradability of β-tricalcium phosphate porous scaffold fabricated via selective laser sintering

2013 ◽  
Vol 60 (2) ◽  
pp. 266-273 ◽  
Author(s):  
Cijun Shuai ◽  
Jingyu Zhuang ◽  
Huanlong Hu ◽  
Shuping Peng ◽  
Defu Liu ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Porous Scaffold ◽  
Selective Laser Sintering ◽  
Laser Sintering
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