scholarly journals Adsorption behavior of antimicrobial peptide histatin 5 on PMMA

2006 ◽  
Vol 77B (1) ◽  
pp. 47-54 ◽  
Author(s):  
Masao Yoshinari ◽  
Tetsuo Kato ◽  
Kenichi Matsuzaka ◽  
Tohru Hayakawa ◽  
Takashi Inoue ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Adsorption Behavior ◽  
Histatin 5

scholarly journals Association between Antimicrobial Peptide Histatin 5 Levels and Prevalence of Candida in Saliva of Patients with Down Syndrome

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 494
Author(s):  
Tomoko Komatsu ◽  
Kiyoko Watanabe ◽  
Nobushiro Hamada ◽  
Eva Helmerhorst ◽  
Frank Oppenheim ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Elderly Patients ◽  
Antimicrobial Peptide ◽  
Total Protein ◽  
The Other ◽  
Enzyme Linked Immunosorbent Assay ◽  
Fungal Colonization ◽  
Candida Colonization ◽  
Histatin 5 ◽  
Oral Candida

There are no studies on Candida colonization and micropeptides of saliva in any patient. Therefore, we studied the effects of the salivary antimicrobial peptide histatin 5 on oral fungal colonization; subjects were subdivided into Down syndrome (D) and normal (N) groups by age: N-1 and D-1, age <20 years; N-2 and D-2, age >40 years. Histatin 5 concentration in saliva was measured by enzyme-linked immunosorbent assay. Oral Candida species were identified using CHROMagar Candida. Candida colonization was significantly enhanced in the D-1 and D-2 groups compared to the N-1 and N-2 groups. There was no predominant difference in salivary histatin 5 concentration between the D-1 and N-1 groups, but it was significantly lower in the D-2 group than in the N-2 group. Only in the N-2 group was there a correlation between the concentration of histatin 5 and total protein, while no correlation was found in the other groups. In elderly patients with Down syndrome, the decrease in histatin 5 shown in this study may lead to oral Candida colony formation. Therefore, the results of this study suggest that a deficiency of the antimicrobial peptide histatin 5 could possibly induce oral Candida infection in DS.

scholarly journals Role of CgTpo4 in Polyamine and Antimicrobial Peptide Resistance: Determining Virulence in Candida glabrata

2021 ◽  
Vol 22 (3) ◽  
pp. 1376
Author(s):  
Mafalda Cavalheiro ◽  
Daniela Romão ◽  
Rui Santos ◽  
Dalila Mil-Homens ◽  
Pedro Pais ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Candida Glabrata ◽  
Defense Mechanism ◽  
Galleria Mellonella ◽  
Antifungal Drugs ◽  
Yeast Cells ◽  
Infection Model ◽  
Histatin 5 ◽  
Host Defense Mechanism ◽  
Antimicrobial Peptide Resistance

Candida glabrata is an emerging fungal pathogen whose success depends on its ability to resist antifungal drugs but also to thrive against host defenses. In this study, the predicted multidrug transporter CgTpo4 (encoded by ORF CAGL0L10912g) is described as a new determinant of virulence in C. glabrata, using the infection model Galleria mellonella. The CgTPO4 gene was found to be required for the C. glabrata ability to kill G. mellonella. The transporter encoded by this gene is also necessary for antimicrobial peptide (AMP) resistance, specifically against histatin-5. Interestingly, G. mellonella’s AMP expression was found to be strongly activated in response to C. glabrata infection, suggesting AMPs are a key antifungal defense. CgTpo4 was also found to be a plasma membrane exporter of polyamines, especially spermidine, suggesting that CgTpo4 is able to export polyamines and AMPs, thus conferring resistance to both stress agents. Altogether, this study presents the polyamine exporter CgTpo4 as a determinant of C. glabrata virulence, which acts by protecting the yeast cells from the overexpression of AMPs, deployed as a host defense mechanism.

scholarly journals The Interactions between the Antimicrobial Peptide P-113 and Living Candida albicans Cells Shed Light on Mechanisms of Antifungal Activity and Resistance

2020 ◽  
Vol 21 (7) ◽  
pp. 2654 ◽  
Author(s):  
Kuang-Ting Cheng ◽  
Chih-Lung Wu ◽  
Bak-Sau Yip ◽  
Ya-Han Chih ◽  
Kuang-Li Peng ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Antimicrobial Peptide ◽  
Oral Candidiasis ◽  
Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Salivary Protein ◽  
Histatin 5 ◽  
C Terminus

In the absence of proper immunity, such as in the case of acquired immune deficiency syndrome (AIDS) patients, Candida albicans, the most common human fungal pathogen, may cause mucosal and even life-threatening systemic infections. P-113 (AKRHHGYKRKFH), an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5, shows good safety and efficacy profiles in gingivitis and human immunodeficiency virus (HIV) patients with oral candidiasis. However, little is known about how P-113 interacts with Candida albicans or its degradation by Candida-secreted proteases that contribute to the fungi’s resistance. Here, we use solution nuclear magnetic resonance (NMR) methods to elucidate the molecular mechanism of interactions between P-113 and living Candida albicans cells. Furthermore, we found that proteolytic cleavage of the C-terminus prevents the entry of P-113 into cells and that increasing the hydrophobicity of the peptide can significantly increase its antifungal activity. These results could help in the design of novel antimicrobial peptides that have enhanced stability in vivo and that can have potential therapeutic applications.

scholarly journals Human antimicrobial peptide histatin 5 is a cell‐ penetrating peptide targeting mitochondrial ATP synthesis in Leishmania

2008 ◽  
Vol 22 (6) ◽  
pp. 1817-1828 ◽  
Author(s):  
Juan Román Luque‐Ortega ◽  
Wim Hof ◽  
Enno C. I. Veerman ◽  
José M. Saugar ◽  
Luis Rivas
Keyword(s):  
Antimicrobial Peptide ◽  
Atp Synthesis ◽  
Cell Penetrating Peptide ◽  
Histatin 5 ◽  
Cell Penetrating ◽  
A Cell ◽  
Peptide Targeting

Metal-Binding and Nuclease Activity of an Antimicrobial Peptide Analogue of the Salivary Histatin 5†

Biochemistry ◽  
2006 ◽  
Vol 45 (51) ◽  
pp. 15373-15383 ◽  
Author(s):  
Sonia Melino ◽  
Mariana Gallo ◽  
Edoardo Trotta ◽  
Francesca Mondello ◽  
Maurizio Paci ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Metal Binding ◽  
Nuclease Activity ◽  
Histatin 5 ◽  
Peptide Analogue

The Human Endogenous Antimicrobial Peptide Ll-37 Stimulates Airway Epithelial Repair

Pneumologie ◽  
2006 ◽  
Vol 59 (12) ◽  
Author(s):  
R Shaykhiev ◽  
C Beißwenger ◽  
K Kändler ◽  
J Senske ◽  
A Püchner ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Airway Epithelial ◽  
Epithelial Repair

Preparation of nanocomposite hydrogels with nanoclay: characterization, swelling properties and dye adsorption behavior

2020 ◽  
Vol 65 (2) ◽  
pp. 119-133
Author(s):  
Nesrimne SEDIIKI ◽  
◽  
Djamel ALIOUCHE ◽  
Imene BOUDHENE ◽  
◽  
...  
Keyword(s):  
Dye Adsorption ◽  
Adsorption Behavior ◽  
Swelling Properties ◽  
Nanocomposite Hydrogels

Antimicrobial Peptide Prodrugs and Mimetics

2016 ◽  
Author(s):  
Marc Devocelle ◽  
Éanna Forde ◽  
André Schütte ◽  
Andrea Molero-Bondia ◽  
Emer Reeves ◽  
...  
Keyword(s):  
Antimicrobial Peptide

LL-37; The Human Epithelial Antimicrobial Peptide and Innate Immunity System

2015 ◽  
Vol 1 (4) ◽  
pp. 76
Author(s):  
Seyadeh Zahra Sajjadiyan ◽  
Sarah Mohammadinejad ◽  
Leila Hassani
Keyword(s):  
Innate Immunity ◽  
Antimicrobial Peptide
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