Sustained-release delivery systems of triclosan for treatment ofStreptococcus mutans biofilm

2006 ◽  
Vol 77B (2) ◽  
pp. 282-286 ◽  
Author(s):  
Doron Steinberg ◽  
Tamir Tal ◽  
Michael Friedman
Keyword(s):  
Sustained Release ◽  
Delivery Systems

Development and Evaluation of Sustained Release Lipid Nanocarriers for Curcumin

2020 ◽  
Vol 5 (3) ◽  
pp. 224-235
Author(s):  
Harshal A. Pawar ◽  
Bhagyashree D. Bhangale
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery Systems ◽  
Biological Activities ◽  
Curcuma Longa ◽  
Research Work ◽  
Elimination Rate ◽  
Delivery Systems ◽  
Physicochemical Stability ◽  
Wide Range

Background: Lipid based excipients have increased acceptance nowadays in the development of novel drug delivery systems in order to improve their pharmacokinetic profiles. Drugs encapsulated in lipids have enhanced stability due to the protection they experience in the lipid core of these nano-formulations. Phytosomes are newly discovered drug delivery systems and novel botanical formulation to produce lipophilic molecular complex which imparts stability, increases absorption and bioavailability of phytoconstituent. Curcumin, obtained from turmeric (Curcuma longa), has a wide range of biological activities. The poor solubility and wettability of curcumin are responsible for poor dissolution and this, in turn, results in poor bioavailability. To overcome these limitations, the curcumin-loaded nano phytosomes were developed to improve its physicochemical stability and bioavailability. Objective: The objective of the present research work was to develop nano-phytosomes of curcumin to improve its physicochemical stability and bioavailability. Methods: Curcumin-loaded nano phytosomes were prepared by using phospholipid Phospholipon 90 H using a modified solvent evaporation method. The developed curcumin nano phytosomes were evaluated by particle size analyzer and differential scanning calorimetry (DSC). Results: Results indicated that phytosomes prepared using curcumin and lipid in the ratio of 1:2 show good entrapment efficiency. The obtained curcumin phytosomes were spherical in shape with a size less than 100 nm. The prepared nano phytosomal formulation of curcumin showed promising potential as an antioxidant. Conclusion: The phytosomal complex showed sustained release of curcumin from vesicles. The sustained release of curcumin from phytosome may improve its absorption and lowers the elimination rate with an increase in bioavailability.

Engineering functional alginate beads for encapsulation of Pickering emulsions stabilized by colloidal particles

RSC Advances ◽  
2016 ◽  
Vol 6 (103) ◽  
pp. 101267-101276 ◽  
Author(s):  
Hongshan Liang ◽  
Bin Zhou ◽  
Jing Li ◽  
Yun He ◽  
Yaqiong Pei ◽  
...  
Keyword(s):  
Sustained Release ◽  
Colloidal Particles ◽  
Alginate Beads ◽  
Delivery Systems ◽  
Pickering Emulsions ◽  
Pharmaceutical Industries ◽  
Hydrophilic Compounds

Pickering emulsions are widely used as delivery systems in food, cosmetics, and pharmaceutical industries for the encapsulation and sustained release of hydrophilic compounds.

scholarly journals Optimising Hydrogel Release Profiles for Viro-Immunotherapy Using Oncolytic Adenovirus Expressing IL-12 and GM-CSF with Immature Dendritic Cells

2020 ◽  
Vol 10 (8) ◽  
pp. 2872 ◽  
Author(s):  
Adrianne L. Jenner ◽  
Federico Frascoli ◽  
Chae-Ok Yun ◽  
Peter S. Kim
Keyword(s):  
Dendritic Cells ◽  
Sustained Release ◽  
Immune Cells ◽  
Fundamental Problem ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Release Profile ◽  
Oncolytic Viruses ◽  
Immature Dendritic Cells ◽  
Release Profiles

Sustained-release delivery systems, such as hydrogels, significantly improve cancer therapies by extending the treatment efficacy and avoiding excess wash-out. Combined virotherapy and immunotherapy (viro-immunotherapy) is naturally improved by these sustained-release systems, as it relies on the continual stimulation of the antitumour immune response. In this article, we consider a previously developed viro-immunotherapy treatment where oncolytic viruses that are genetically engineered to infect and lyse cancer cells are loaded onto hydrogels with immature dendritic cells (DCs). The time-dependent release of virus and immune cells results in a prolonged cancer cell killing from both the virus and activated immune cells. Although effective, a major challenge is optimising the release profile of the virus and immature DCs from the gel so as to obtain a minimum tumour size. Using a system of ordinary differential equations calibrated to experimental results, we undertake a novel numerical investigation of different gel-release profiles to determine the optimal release profile for this viro-immunotherapy. Using a data-calibrated mathematical model, we show that if the virus is released rapidly within the first few days and the DCs are released for two weeks, the tumour burden can be significantly decreased. We then find the true optimal gel-release kinetics using a genetic algorithm and suggest that complex profiles present unnecessary risk and that a simple linear-release model is optimal. In this work, insight is provided into a fundamental problem in the growing field of sustained-delivery systems using mathematical modelling and analysis.

Dexamethasone Degradation in Aqueous Medium and Implications for Correction of In Vitro Release from Sustained Release Delivery Systems

2019 ◽  
Vol 20 (8) ◽  
Author(s):  
Brock Matter ◽  
Alireza Ghaffari ◽  
David Bourne ◽  
Yan Wang ◽  
Stephanie Choi ◽  
...  
Keyword(s):  
Sustained Release ◽  
Aqueous Medium ◽  
In Vitro Release ◽  
Delivery Systems ◽  
Vitro Release

Imprinted hydrophilic nanospheres as drug delivery systems for 5-fluorouracil sustained release

2009 ◽  
Vol 17 (1) ◽  
pp. 72-77 ◽  
Author(s):  
G. Cirillo ◽  
F. Iemma ◽  
F. Puoci ◽  
O. I. Parisi ◽  
M. Curcio ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery Systems ◽  
Delivery Systems
Sign in / Sign up

Export Citation Format

Share Document