An animal evaluation of a paste of chitosan glutamate and hydroxyapatite as a synthetic bone graft material

2003 ◽  
Vol 67B (1) ◽  
pp. 603-609 ◽  
Author(s):  
D. P. Mukherjee ◽  
A. S. Tunkle ◽  
R. A. Roberts ◽  
A. Clavenna ◽  
S. Rogers ◽  
...  
Keyword(s):  
Bone Graft ◽  
Graft Material ◽  
Bone Graft Material ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

Response of canine bone to a synthetic bone graft material

1993 ◽  
Vol 12 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Kenneth R St. John ◽  
Lyle D Zardiackas ◽  
R.John Black ◽  
Rosa Armstrong
Keyword(s):  
Bone Graft ◽  
Graft Material ◽  
Bone Graft Material ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

Chronology of the Radiographic Appearances of the Calcium Sulfate-Calcium Phosphate Synthetic Bone Graft Composite following Resection of Bone Tumors: A Follow-up Study of Postoperative Appearances

2016 ◽  
Vol 67 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Victoria Tan ◽  
Nathan Evaniew ◽  
Karen Finlay ◽  
Erik Jurriaans ◽  
Michelle Ghert ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Graft ◽  
Calcium Sulfate ◽  
Bone Ingrowth ◽  
Graft Material ◽  
Synthetic Graft ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Graft Resorption

Purpose The objective of the study was to characterize the radiographic appearance of graft resorption and new bone incorporation into a postresection defect of the calcium-sulfate calcium-phosphate synthetic bone graft composite following resection of benign bone tumours. Methods Twenty-five patients who underwent treatment with the CaSO4/CaPO4 synthetic graft following bone tumour resection were retrospectively identified from our oncology database. Postoperative radiographs were assessed for: 1) combined partial graft resorption and ingrowth at the graft site; 2) complete graft resorption with complete incorporation of new bone into the defect. After chronologically grouping radiographs, the volume of graft material used to fill bony defects, radiographic evidence of complications, and patterns of resorption were recorded. Results Partial resorption of graft material/partial ingrowth of new bone was seen in 21 patients at 2.5 months postoperatively. Complete resorption of graft with complete new bone incorporation at the graft site was seen in 94% of cases (15 of 16) by 10 months after surgery. Mean time to complete incorporation of new bone was 6.7 months. Time to resorption of the graft with new bone ingrowth was found to be related to the volume of graft used with smaller volumes showing earlier resorption. For all cases demonstrating resorption (21 of 21), the pattern observed was peripheral to central. Five patients developed complications, including tumour recurrence, cyst formation, and graft site infection. Conclusion Our study suggests a characteristic time and volume related radiographic pattern of resorption and new bone ingrowth with the CaSO4/CaPO4 synthetic graft. Findings that deviate from this pattern may represent complication and warrant additional follow-up.

The New Art of Bone Graft Substitute Design

2007 ◽  
Vol 330-332 ◽  
pp. 959-962
Author(s):  
Ernst Dieter Klinkenberg ◽  
Hans Georg Neumann ◽  
Ulrike Bulnheim ◽  
Joachim Rychly
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Graft Material ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Vital Cell ◽  
Design And Manufacturing ◽  
Bone Graft Substitutes ◽  
First Time

A new method of design and manufacturing of bone graft substitutes is introduced. For the first time it is possible to prepare bone graft substitutes with a directed and controlled pore structure. Furthermore, the formation of sophisticated geometries is feasible. First in vitro investigations with cell cultures show a vital cell growing on the synthetic bone graft material. Numerous applications are possible.

scholarly journals 405 Radiological Analysis of Gentamicin Eluting Synthetic Bone Graft Substitute Used in The Management of Gustilo IIIB Open Fractures

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
A Aljawadi ◽  
I Madhi ◽  
T Naylor ◽  
M Elmajee ◽  
A Islam ◽  
...  
Keyword(s):  
Bone Graft ◽  
Cortical Thickness ◽  
Bone Graft Substitute ◽  
Fracture Site ◽  
Open Fractures ◽  
X Rays ◽  
Radiographic Images ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

Abstract Background Management of traumatic bone void associated with Gustilo IIIB open fractures is challenging. Gentamicin eluting synthetic bone graft substitute (Cerament-G) had been recently utilised for the management of patients with these injuries. This study aims to assess radiological signs of Cerament-G remodelling. Method Retrospective data analysis of all patients admitted to our unit with IIIB open fractures who had Cerament-G applied as avoid filler. Postoperative radiographic images of the fracture site at 6-weeks, 3-months, 6-months and at the last follow-up were reviewed. The radiological signs of Cerament-G integration, percent of void healing, and bone cortical thickness at the final follow-up were assessed. Results 34 patients met our inclusion criteria, mean age: 42 years. Mean follow-up time was 20 months. 59% of patients had excellent (>90%) void filling, 26.4% of patients had 50-90% void filling, and 14.6% had < 50% void filling. Normal bone cortical thickness was restored on AP and Lateral views in 55.8% of patients. No residual Cerement-G was seen on X-rays at the final follow-up in any of the patients. Conclusions Our results showed successful integration of Cerament-G with excellent void filling and normal cortical thickness achieved in more than half of the patients.

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