Implantable magnetic nanofibers with ON–OFF switchable release of curcumin for possible local hyperthermic chemotherapy of melanoma

2021 ◽  
Author(s):  
Wenju Wei ◽  
Nosratollah Zarghami ◽  
Mozhgan Abasi ◽  
Yavuz Nuri Ertas ◽  
Younes Pilehvar
Keyword(s):  
Hyperthermic Chemotherapy ◽  
Magnetic Nanofibers

Mussel-Inspired Electrospun Smart Magnetic Nanofibers for Hyperthermic Chemotherapy

2015 ◽  
Vol 25 (19) ◽  
pp. 2867-2875 ◽  
Author(s):  
Amin GhavamiNejad ◽  
Arathyram Ramachandra Kurup Sasikala ◽  
Afeesh Rajan Unnithan ◽  
Reju George Thomas ◽  
Yong Yeon Jeong ◽  
...  
Keyword(s):  
Hyperthermic Chemotherapy ◽  
Magnetic Nanofibers

scholarly journals Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy

2021 ◽  
Vol 22 (3) ◽  
pp. 1239
Author(s):  
Matilde Zaballos ◽  
Mercedes Power ◽  
María Iluminada Canal-Alonso ◽  
María Ángeles González-Nicolás ◽  
Wenceslao Vasquez-Jimenez ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Fluid Management ◽  
Urine Volume ◽  
Chemotherapeutic Agents ◽  
Control Group ◽  
Specific Data ◽  
Preoperative Risk Factors ◽  
Hyperthermic Chemotherapy ◽  
Chemotherapy Perfusion ◽  
Nephroprotective Effect

Cisplatin is one of the most widely used chemotherapeutic agents in oncology, although its nephrotoxicity limits application and dosage. We present the results of a clinical study on prophylaxis of cisplatin-induced nephrotoxicity in patients with peritoneal carcinomatosis undergoing cytoreduction and hyperthermic intraperitoneal intraoperative chemotherapy (HIPEC-cisplatin). Prophylaxis was with imipenem/cilastatin. Cilastatin is a selective inhibitor of renal dehydropeptidase I in the proximal renal tubule cells that can reduce the nephrotoxicity of cisplatin. Unfortunately, cilastatin is not currently marketed alone, and can only be administered in combination with imipenem. The study has a retrospective part that serves as a control (n = 99 patients receiving standard surgical prophylaxis) and a prospective part with imipenem/cilastatin prophylaxis corresponding to the study group (n = 85 patients). In both groups, we collected specific data on preoperative risk factors of renal damage, fluid management, hemodynamic control, and urine volume during surgery (including the hyperthermic chemotherapy perfusion), as well as data on hemodynamic and renal function during the first seven days after surgery. The main finding of the study is that cilastatin may exert a nephroprotective effect in patients with peritoneal carcinomatosis undergoing cytoreduction and hyperthermic intraperitoneal cisplatin perfusion. Creatinine values remained lower than in the control group (ANOVA test, p = 0.037). This translates into easier management of these patients in the postoperative period, with significantly shorter intensive care unit (ICU) and hospital stay.

Effect of aluminum doped iron oxide nanoparticles on magnetic properties of the polyacrylonitrile nanofibers

2017 ◽  
Vol 37 (2) ◽  
pp. 135-141
Author(s):  
Armin Ourang ◽  
Soheil Pilehvar ◽  
Mehrzad Mortezaei ◽  
Roya Damircheli
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Negative Interaction ◽  
Magnetic Nanofibers

Abstract In this work, polyacrylonitrile (PAN) was electrospun with and without magnetic nanoparticles (aluminum doped iron oxide) and was turned into magnetic nanofibers. The results showed that nanofibers diameter decreased from 700 nm to 300 nm by adding nanoparticles. Furthermore, pure PAN nanofibers were indicated to have low magnetic ability due to polar bonds that exist in their acrylonitrile groups. Obviously by adding only 4 wt% of the nanoparticles to PAN nanofibers, magnetic ability soared by more than 10 times, but at a higher percentage, it was shown to change just a little due to negative interaction among nanoparticles. This event relates to antiferromagnetically coupling of nanoparticles due to incomplete dispersion at higher percentage.

320 Simultaneous hyperthermic-chemotherapy using a single anti-cancer compound with magnetism in glioblastoma animal model

2015 ◽  
Vol 51 ◽  
pp. S61
Author(s):  
M. Ohtake ◽  
M. Umemura ◽  
I. Sato ◽  
K. Oda ◽  
A. Nagasako ◽  
...  
Keyword(s):  
Animal Model ◽  
Hyperthermic Chemotherapy ◽  
Anti Cancer
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