Controlled release of ciliary neurotrophic factor from bioactive nerve grafts promotes nerve regeneration in rats with facial nerve injuries

2021 ◽  
Author(s):  
Fukai Ma ◽  
Hanming Wang ◽  
Xiaosheng Yang ◽  
Yiwei Wu ◽  
Chenlong Liao ◽  
...  
Keyword(s):  
Controlled Release ◽  
Facial Nerve ◽  
Nerve Regeneration ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Nerve Injuries ◽  
Nerve Grafts ◽  
Facial Nerve Injuries

Surgical Management of Iatrogenic Facial Nerve Injuries

1994 ◽  
Vol 111 (5) ◽  
pp. 606-610 ◽  
Author(s):  
J. Douglas Green ◽  
Clough Shelton ◽  
Derald E. Brackmann
Keyword(s):  
Facial Nerve ◽  
Surgical Management ◽  
Nerve Graft ◽  
Nerve Grafting ◽  
Nerve Injuries ◽  
Neural Repair ◽  
Nerve Grafts ◽  
Facial Nerve Injuries ◽  
Direct Anastomosis ◽  
Grade Iii

Surgical management of an latrogenic facial nerve injury represents a significant challenge for the otologic surgeon. The decision to perform facial nerve grafting is a difficult one and is based on the extent of injury to the nerve. We conducted a review of 22 patients who had sustained latrogenic facial nerve injuries during otologic surgery that required surgical exploration. The facial nerve was transected more than half its diameter in 13 of the patients. All of these patients' nerves were repaired either with direct reanastomosis of the facial nerve or with a cable nerve graft. The transection was less than 50% in nine of the patients in the study group. Eight of these patients underwent only decompression of the facial nerve. No patient with a neural repair (direct anastomosis or cable graft) had better than a House grade III result. All of the patients undergoing direct anastomosis of the nerve obtained a House grade III result. The most common result in patients undergoing cable nerve grafting was a House grade IV. The only patients with normal or near-normal facial nerve function (House grade I or II) had only decompression of the facial nerve. Five of the eight patients undergoing decompression had results similar to those undergoing cable nerve grafts. We conclude that acceptable results can be obtained when the facial nerve is repaired by direct anastomosis or a cable nerve graft. These results are comparable with those of patients treated with decompression only. When in doubt as to the extent of injury, it is preferable to repair the facial nerve, because the extent of injury may be underestimated.

Effect of Epineurial Neurorrhaphy on Restoration of Facial Nerve Injuries with Different Levels of Neurotmesis in a Rat Model: A Pilot Study

2018 ◽  
Vol 112 ◽  
pp. e14-e22 ◽  
Author(s):  
Suming Shi ◽  
Yuhang Han ◽  
Lei Xu ◽  
Jianfeng Li ◽  
Yuechen Han ◽  
...  
Keyword(s):  
Pilot Study ◽  
Facial Nerve ◽  
Rat Model ◽  
Nerve Injuries ◽  
Facial Nerve Injuries ◽  
Different Levels

Ciliary Neurotrophic Factor for Acceleration of Peripheral Nerve Regeneration: An Experimental Study

2004 ◽  
Vol 20 (04) ◽  
pp. 323-327 ◽  
Author(s):  
Jian Zhang ◽  
William Lineaweaver ◽  
Tanya Oswald ◽  
Zhengrong Chen ◽  
Zhongwei Chen ◽  
...  
Keyword(s):  
Experimental Study ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Neurotrophic Factor ◽  
Peripheral Nerve Regeneration ◽  
Ciliary Neurotrophic Factor

scholarly journals Can MDCT Scan of the Temporal Bone Looking at Pneumatization Predict Surgical Vulnerability of the Facial Nerve?

2019 ◽  
pp. 014556131987952
Author(s):  
Mikail Inal ◽  
Nuray Bayar Muluk ◽  
Mehmet Hamdi Şahan ◽  
Neşe Asal ◽  
Gökçe Şimşek ◽  
...  
Keyword(s):  
Facial Nerve ◽  
Facial Canal ◽  
Nerve Injuries ◽  
Mastoid Pneumatization ◽  
Computed Tomography Scans ◽  
Facial Nerve Injuries ◽  
Important Landmark ◽  
Facial Canal Dehiscence ◽  
Males And Females ◽  
Canal Dehiscence

Objectives: The aim of this study is to investigate the scutum–cochleariform process (CP) and scutum–promontorium distances according to the mastoid pneumatization condition. Methods: Two hundred temporal multidetector computed tomography scans (90 males and 110 females) were evaluated retrospectively. The scutum-CP and scutum–promontorium distances were measured. Facial canal dehiscence (FCD) in the tympanic segment and mastoid pneumatization were also evaluated. Results: The distances between scutum-CP and scutum–promontorium were not different between males and females and between right and left sides. Facial canal dehiscence in the tympanic segment was detected: 5.6% (right) and 7.8% (left) in males and 5.5% (right) and 10.0% (left) in females. Grade 4 (100%) pneumatization was detected mainly in 55.6% to 57.8% of the patients in both genders. Grade 0 (0%) pneumatization (sclerosis) was detected in 22.2% to 28.2% of both males and females. In more pneumatized mastoids, the scutum-CP and scutum–promontorium distances increased. In sclerotic mastoids, the scutum-CP and scutum–promontorium distances decreased. Facial canal dehiscence rates were not related to the mastoid pneumatization levels. Conclusion: Cochleariform process is an important landmark to localize the tympanic segment of the facial canal. In sclerosed mastoids, scutum-CP and scutum–promontorium distances decreased. There was no relationship between FCD rates and mastoid pneumatization levels. It may be due to the development of FCD that occurs during the intrauterine period. In endoscopic and classic ear surgeries, mastoid pneumatization must be evaluated preoperatively to avoid facial nerve injuries.

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