Application of nondestructive mechanical characterization testing for creating in vitro vessel models with material properties similar to human neurovasculature

2021 ◽  
Author(s):  
Nicholas G. Norris ◽  
William C. Merritt ◽  
Timothy A. Becker
Keyword(s):  
Material Properties ◽  
Mechanical Characterization

Cytocompatibility and Material Properties of Poly-carbonate Urethane/Carbon Nanofiber Composites for Neural Applications

2003 ◽  
Vol 774 ◽  
Author(s):  
Janice L. McKenzie ◽  
Michael C. Waid ◽  
Riyi Shi ◽  
Thomas J. Webster
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanofibers ◽  
Material Properties ◽  
Carbon Nanofiber ◽  
Scar Tissue ◽  
Tissue Response ◽  
Positive Interactions ◽  
Weight Percentage ◽  
Poly Carbonate

AbstractCarbon nanofibers possess excellent conductivity properties, which may be beneficial in the design of more effective neural prostheses, however, limited evidence on their cytocompatibility properties exists. The objective of the present in vitro study was to determine cytocompatibility and material properties of formulations containing carbon nanofibers to predict the gliotic scar tissue response. Poly-carbonate urethane was combined with carbon nanofibers in varying weight percentages to provide a supportive matrix with beneficial bulk electrical and mechanical properties. The substrates were tested for mechanical properties and conductivity. Astrocytes (glial scar tissue-forming cells) were seeded onto the substrates for adhesion. Results provided the first evidence that astrocytes preferentially adhered to the composite material that contained the lowest weight percentage of carbon nanofibers. Positive interactions with neurons, and, at the same time, limited astrocyte functions leading to decreased gliotic scar tissue formation are essential for increased neuronal implant efficacy.

Thermal Stress in Teeth

1978 ◽  
Vol 57 (4) ◽  
pp. 571-582 ◽  
Author(s):  
B.A. Lloyd ◽  
M.B. McGinley ◽  
W.S. Brown
Keyword(s):  
Thermal Stress ◽  
Numerical Analysis ◽  
Material Properties ◽  
Thermal Stresses ◽  
In Vivo Studies ◽  
Tooth Structure ◽  
Analysis Techniques ◽  
Tooth Type

Observations of crack damage in the tooth structure from in vivo studies and in vitro experimental thermal cycling studies were combined with numerical analysis techniques to identify and isolate the influence of thermal stresses an the creation and propagation of cracks in teeth. The factors considered in this study included: (a) variations in tooth type or geometry (molar, bicuspid, etc.), (b) tooth age, (c) material properties of the tooth, (d) the magnitude of the change in the temperature of the environment surrounding the tooth, and (e) the thermal resistance between the tooth and the medium surrounding the tooth.

scholarly journals Droplet Based Measurements of Mechanical Forces and Material Properties, In Vivo and In Vitro

2018 ◽  
Vol 114 (3) ◽  
pp. 666a
Author(s):  
Elijah Shelton ◽  
Adam Lucio ◽  
Hannah Gustafson ◽  
Alessandro Mongera ◽  
Friedhelm Serwane ◽  
...  
Keyword(s):  
Material Properties ◽  
Mechanical Forces

scholarly journals Force spectroscopy-based simultaneous topographical and mechanical characterization to study polymer-to-polymer interactions in coated alginate microspheres

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Maria Virumbrales-Muñoz ◽  
Edorta Santos-Vizcaino ◽  
Laura Paz ◽  
Amparo Maria Gallardo-Moreno ◽  
Gorka Orive ◽  
...  
Keyword(s):  
Cross Correlation ◽  
Mechanical Characterization ◽  
Force Spectroscopy ◽  
Covalent Bonding ◽  
Design Rationale ◽  
Polymer Interactions ◽  
First Time ◽  
Hydrogel Microspheres

AbstractCell-laden hydrogel microspheres have shown encouraging outcomes in the fields of drug delivery, tissue engineering or regenerative medicine. Beyond the classical single coating with polycations, many other different coating designs have been reported with the aim of improving mechanical properties and in vivo performance of the microspheres. Among the most common strategies are the inclusion of additional polycation coatings and the covalent bonding of the semi-permeable membranes with biocompatible crosslinkers such as genipin. However, it remains challenging to characterize the effects of the interactions between the polycations and the hydrogel microspheres over time in vitro. Here we use a force spectroscopy-based simultaneous topographical and mechanical characterization to study polymer-to-polymer interactions in alginate microspheres with different coating designs, maintaining the hydrogels in liquid. In addition to classical topography parameters, we explored, for the first time, the evolution of peak/valley features along the z axis via thresholding analysis and the cross-correlation between topography and stiffness profiles with resolution down to tens of nanometers. Thus, we demonstrated the importance of genipin crosslinking to avoid membrane detachment in alginate microspheres with double polycation coatings. Overall, this methodology could improve hydrogel design rationale and expedite in vitro characterization, therefore facilitating clinical translation of hydrogel-based technologies.

Experimental in vitro mechanical characterization of porcine Glisson's capsule and hepatic veins

2011 ◽  
Vol 44 (9) ◽  
pp. 1678-1683 ◽  
Author(s):  
Sagar Umale ◽  
Simon Chatelin ◽  
Nicolas Bourdet ◽  
Caroline Deck ◽  
Michele Diana ◽  
...  
Keyword(s):  
Mechanical Characterization ◽  
Hepatic Veins

scholarly journals Cross-linking Electrospun Polydioxanone-Soluble Elastin Blends: Material Characterization

2008 ◽  
Vol 3 (1) ◽  
pp. 155892500800300 ◽  
Author(s):  
Michael J. McClure ◽  
Scott A. Sell ◽  
Catherine P. Barnes ◽  
Whitney C. Bowen ◽  
Gary L. Bowlin
Keyword(s):  
Femoral Artery ◽  
Material Properties ◽  
In Vivo Studies ◽  
Uniaxial Tensile ◽  
Cross Linking ◽  
Materials Testing ◽  
Uniaxial Tensile Testing ◽  
The Cross

The purpose of this study was to establish whether material properties of elastin co-electrospun with polydioxanone (PDO) would change over time in both the uncross-linked state and the cross-linked state. First, uncross-linked scaffolds were placed in phosphate buffered saline (PBS) for three separate time periods: 15 minutes, 1 hour, and 24 hours, and subsequently tested using uniaxial materials testing. Several cross-linking reagents were then investigated to verify their ability to crosslink elastin: 1–ethyl-3–(dimethylaminopropyl)-carbodiimide (EDC), ethylene glycol diglycidyl ether (EGDE), and genipin. Uniaxial tensile testing was performed on scaffolds cross-linked with EDC and genipin, yielding results that warranted further investigation for PDO-elastin blends. Material properties of the cross-linked scaffolds were then found within range of both pig femoral artery and human femoral artery. These results demonstrate PDO-elastin blends could potentially be favorable as vascular grafts, thus warranting future in vitro and in vivo studies.

scholarly journals Mechanical Characterization of Rabbit Pulmonary Vein Sleeves in In Vitro Intact Ring Preparation

2008 ◽  
Vol 71 (12) ◽  
pp. 610-618
Author(s):  
Hsiang-Ning Luk ◽  
Chu-Pin Lo ◽  
Hui-Chun Tien ◽  
Daniel Lee ◽  
Zong-Li Chen ◽  
...  
Keyword(s):  
Pulmonary Vein ◽  
Mechanical Characterization

scholarly journals Mucoadhesive films inside the colonic tube: performance in a three-dimensional world

2008 ◽  
Vol 5 (28) ◽  
pp. 1353-1362 ◽  
Author(s):  
D Dodou ◽  
M van den Berg ◽  
J van Gennip ◽  
P Breedveld ◽  
P.A Wieringa
Keyword(s):  
Theoretical Model ◽  
Contact Area ◽  
Material Properties ◽  
Three Dimensional ◽  
Colonic Tissue ◽  
Colonic Wall ◽  
Geometric Characteristics ◽  
Simple Theoretical Model ◽  
Frictional Behaviour

A self-propelling colonoscopic device moving inside the colonic tube should be able to periodically grip safely to the colonic wall as well as to manipulate the generated friction. The feasibility of achieving high grip and friction manipulation by covering the device with mucoadhesive films is experimentally tested. More precisely, the frictional behaviour of mucoadhesive films inside the colonic tube is tested in vitro in porcine colon. It appears that mucoadhesive films generate significantly higher friction than conventional materials (ANOVA p =0, 95% CIs=−3.04, −2.14). The geometry of the film plays a role as well. When holes are, for instance, present in the film geometry and are large enough so that the colonic tissue can wrap their borders, friction can be significantly increased (ANOVA p =0, 95% CIs=−2.53, −1.26). By altering the contact area or the film geometry, friction manipulation can be achieved. Moreover, a simple theoretical model is developed and experimentally verified ( R =0.92). The model can be used to estimate the level of the friction generated by three-dimensional configurations of mucoadhesive films as a function of their geometric characteristics and the material properties of the colon.

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